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1.发明公开IMPLANTABLE BIOCOMPATIBLE IMMUNOISOLATORY VEHICLE FOR DELIVERY OF SELECTED THERAPEUTIC PRODUCTS 失效植入的生物相容性免疫绝缘子货船物质提供选择，治疗产品。
公开(公告)号：EP0585368A1
公开(公告)日：1994-03-09
申请号：EP92912606.0
申请日：1992-04-22
发明人： DIONNE, Keith, E. , EMERICH, Dwaine, F. , HOFFMAN, Diane , SCHARP, David, W. , LACY, Paul, E. , AEBISCHER, Patrick , SANBERG, Paul, R. , CHRISTENSON, Lisa , HEGRE, Orion, D. , VASCONCELLOS, Alfred, V. , LYSAGHT, Michael, J. , GENTILE, Frank, T.
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.
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公开(公告)号：EP0674497B1
公开(公告)日：2002-07-24
申请号：EP94902302.2
申请日：1993-11-16
发明人： GENTILE, Frank, T. , TRESCO, Patrick, A. , HAZLETT, Tyrone , FLANAGAN, Thomas , DOHERTY, Edward, J. , REIN, David , HOLLAND, Laura
CPC分类号： A61K9/0024
摘要： Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have selected permeability characteristics based upon their particular usage and desired viral retentivity characteristics.
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3.发明授权IMPLANTABLE BIOCOMPATIBLE IMMUNOISOLATORY VEHICLE FOR DELIVERY OF SELECTED THERAPEUTIC PRODUCTS 失效植入，以提供选择的生物相容性免疫绝缘子承运人物质，治疗产品
公开(公告)号：EP0585368B1
公开(公告)日：1997-08-06
申请号：EP92912606.8
申请日：1992-04-22
发明人： DIONNE, Keith, E. , EMERICH, Dwaine, F. , HOFFMAN, Diane , SCHARP, David, W. , LACY, Paul, E. , AEBISCHER, Patrick , SANBERG, Paul, R. , CHRISTENSON, Lisa , HEGRE, Orion, D. , VASCONCELLOS, Alfred, V. , LYSAGHT, Michael, J. , GENTILE, Frank, T.
IPC分类号： A61F13/00
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.
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公开(公告)号：EP0586559B1
公开(公告)日：1996-02-21
申请号：EP92913022.7
申请日：1992-05-21
CPC分类号： G02B6/032 , B01D69/08 , B01D69/085 , B01D69/087 , D01D5/24 , Y10T428/2935 , Y10T428/2975
摘要： A nozzle assembly for forming hollow fibers, particularly a 'Z-fiber' having longitudinally oriented trabeculae with the fiber wall, is disclosed. The nozzle assembly (10) contains a replaceable nozzle cap (28), a replaceable seal-guide (26), and a retractable central bore (14) used to supply core material for the hollow fibers. The Z-fibers are particularly useful in enabling cells, solutes, or the like, to enter the fiber wall and move longitudinally into the center of the fiber wall.
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公开(公告)号：EP0674497A1
公开(公告)日：1995-10-04
申请号：EP94902302.0
申请日：1993-11-16
发明人： GENTILE, Frank, T. , TRESCO, Patrick, A. , HAZLETT, Tyrone , FLANAGAN, Thomas , DOHERTY, Edward, J. , REIN, David , HOLLAND, Laura
CPC分类号： A61K9/0024
摘要： Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have selected permeability characteristics based upon their particular usage and desired viral retentivity characteristics.
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公开(公告)号：EP0586559A1
公开(公告)日：1994-03-16
申请号：EP92913022.0
申请日：1992-05-21
CPC分类号： G02B6/032 , B01D69/08 , B01D69/085 , B01D69/087 , D01D5/24 , Y10T428/2935 , Y10T428/2975
摘要： Un ensemble à ajutage de formation de fibres creuses, en particulier une "fibre Z" ayant des trabécules orientées dans le sens longitudinal avec la paroi de la fibre est décrit. L'ensemble à ajutage (10) contient un chapeau d'ajutage remplaçable (28), un guide de joint d'étanchéité remplaçable (26) et un alésage central rétractable (14) utilisé pour amener l'âme constituant le matériau de fabrication des fibres creuses. Les fibres en Z sont particulièrement utiles pour permettre à des cellules, des solutés ou autres d'entrer dans la paroi de la fibre et de se déplacer longitudinalement dans le centre de la paroi de la fibre.
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