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    COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES
    1.
    发明公开
    COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES 审中-公开
    组合物和方法组合证明抗体的

    公开(公告)号：EP2150818A1

    公开(公告)日：2010-02-10

    申请号：EP08780412.6

    申请日：2008-02-12

    申请人： Battelle Energy Alliance, LLC

    发明人： APEL, William, A. ,  THOMPSON, Vicki, S. ,  TAYLOR, Elizabeth, A. ,  BRUHN, Debby, F.

    IPC分类号： G01N33/53

    CPC分类号： G01N33/946 ,  G01N33/543 ,  G01N33/58 ,  G01N33/581 ,  G01N33/94 ,  G01N33/948

    摘要： Compositions are disclosed. One embodiment of a composition comprises a first antibody having an affinity for an antigen and a second antibody having an affinity for the first antibody, wherein at least one antibody is conjugated to a marker, and wherein the antigen is not present in the composition. Further disclosed are methods of using compositions according to the invention for analyzing a biological sample by antibody profiling for identifying forensic samples or detecting the presence of an analyte. In embodiments of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, may be coupled to a test for identity such that the results of the assay may be positively correlated to the subject's identity.

    HIGH TEMPERATURE AND ALKALINE STABLE CATALASE
    3.
    发明公开
    HIGH TEMPERATURE AND ALKALINE STABLE CATALASE 审中-公开
    高温和碱性过氧化氢酶稳定

    公开(公告)号：EP1680500A2

    公开(公告)日：2006-07-19

    申请号：EP04810312.1

    申请日：2004-11-03

    申请人： Battelle Energy Alliance, LLC

    发明人： THOMPSON, Vicki, S. ,  APEL, William, A. ,  SCHALLER, Kastli, D.

    IPC分类号： C12N1/00

    CPC分类号： C12N9/0065 ,  C12Y111/01006

    摘要： The invention relates to thermal and pH stable catalases. One catalase of the invention was purified and characterized from Thermus brockianus. As a part of the characterization, the enzyme was compared to typical catalases from commercial sources and found to be significantly more thermal/alkaline stable than these other enzymes. The catalase purified from T. brockianus consists of four identical subunits having a molecular mass of approximately 42.5 kDa, for a total molecular mass of approximately 178 kDa.

    ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL
    4.
    发明公开
    ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL 审中-公开
    用于鉴定生物材料的个体或来源的抗体概况，方法和设备

    公开(公告)号：EP2971286A2

    公开(公告)日：2016-01-20

    申请号：EP14770227.8

    申请日：2014-03-12

    申请人： Battelle Energy Alliance, LLC

    发明人： APEL, William, A. ,  THOMPSON, Vicki, S. ,  LACEY, Jeffrey, A. ,  PARK, Shawna

    IPC分类号： C40B30/04 ,  C40B40/10 ,  G01N33/53

    CPC分类号： G01N33/6854

    摘要： A sample of a biological material having individual-specific antibodies is contacted with an array of less than about 200 proteins on a support to bind some of the individual-specific antibodies to the proteins of the array to form immune complexes. A detection agent with an interacting protein for conjugation to a marker is applied to the array to detect the immune complexes and obtain an antibody profile, which is compared to a known antibody profile obtained from an individual. The array may further include control spots including human IgG to form control complexes and volume assessment spots including volume determination proteins to form volume complexes. Intensity of the control complexes may be detected to determine if results of the identifying are complete. Intensity of the volume complexes may be detected to determine if a volume of the sample is sufficient for an accurate result.

    摘要翻译： 使具有个体特异性抗体的生物材料样品与载体上小于约200个蛋白质的阵列接触，以将一些个体特异性抗体与阵列的蛋白质结合以形成免疫复合物。 将具有用于与标记物缀合的相互作用蛋白质的检测剂应用于阵列以检测免疫复合物并获得抗体谱，其与从个体获得的已知抗体谱相比较。 阵列可以进一步包括对照斑点，包括人IgG以形成对照复合物和包括体积测定蛋白质在内的体积评估点以形成体积复合物。 可以检测对照复合物的强度以确定鉴定的结果是否完整。 可以检测体积复合物的强度以确定样品的体积是否足以获得准确的结果。

    IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL
    5.
    发明公开
    IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL 审中-公开
    识别歧视性蛋白能个人识别抗体分析和方法及装置

    公开(公告)号：EP2478363A2

    公开(公告)日：2012-07-25

    申请号：EP10819278.2

    申请日：2010-09-17

    申请人： Battelle Energy Alliance, LLC

    发明人： APEL, William, A. ,  THOMPSON, Vicki, S. ,  LACEY, Jeffrey, A. ,  GENTILLON, Cynthia, A.

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6845

    摘要： A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.