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1.发明公开
公开(公告)号：EP2277555A1
公开(公告)日：2011-01-26
申请号：EP10008758.4
申请日：2005-08-04
发明人： Anderle, Heinz , Matthiessen, Peter , Schwarz, Hans-Peter , Turecek, Peter , Kreil, Thomas , Boggs, Daniel R.
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a non-transparent biological fluid.
摘要翻译： 本发明涉及一种用于从一个或多个光源的有效剂量单色或多色光的灭活存在于非透明生物液体中的微生物的确定性采矿的方法。
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2.发明公开Device for calibration in a method for the validatable inactivation of pathogens in a biological fluid by irradiation 有权用于校准在用于核查灭活病原体的方法中通过照射生物流体的装置
公开(公告)号：EP2266630A1
公开(公告)日：2010-12-29
申请号：EP10009727.8
申请日：2004-02-27
发明人： Anderle, Heinz , Matthiessen, Peter , Schwarz, Hans-Peter , Turecek, Peter , Kreil, Thomas , Boggs, Daniel R.
CPC分类号： G01J1/08 , A61L2/0011 , A61L2/0017 , A61L2/0052 , A61L2/10 , A61L2/28 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M2205/053 , C02F1/32 , C02F2201/326 , G01J1/42 , G01J1/48
摘要： The present invention relates to a device for calibration in a method for the inactivation of microorganism in a biological fluid, comprising irradiating the biological fluid with an effective dose of monochromatic or polychromatic light from one or more light sources, wherein the effective dose is determined by measuring the effect of the monochromatic or polychromatic light on a dosimetric solution.
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3.发明授权Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741B1
公开(公告)日：2013-08-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
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4.发明授权Device for calibration in a method for the validatable inactivation of pathogens in a biological fluid by irradiation 有权用于校准在用于核查灭活病原体的方法中通过照射生物流体的装置
公开(公告)号：EP2266630B1
公开(公告)日：2013-12-25
申请号：EP10009727.8
申请日：2004-02-27
发明人： Anderle, Heinz , Matthiessen, Peter , Schwarz, Hans-Peter , Turecek, Peter , Kreil, Thomas , Boggs, Daniel R.
CPC分类号： G01J1/08 , A61L2/0011 , A61L2/0017 , A61L2/0052 , A61L2/10 , A61L2/28 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M2205/053 , C02F1/32 , C02F2201/326 , G01J1/42 , G01J1/48
摘要： The present invention relates to a device for calibration in a method for the inactivation of microorganism in a biological fluid, comprising irradiating the biological fluid with an effective dose of monochromatic or polychromatic light from one or more light sources, wherein the effective dose is determined by measuring the effect of the monochromatic or polychromatic light on a dosimetric solution.
摘要翻译： 本发明涉及一种设备，用于校准在微生物的在生物流体中的失活的方法，包括用来自一个或多个光源的有效剂量单色或多色光的照射生物流体，worin有效剂量是确定性由开采 测量单色或多色光上的剂量测定溶液的效果。
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5.发明公开Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741A1
公开(公告)日：2012-03-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The present invention relates to an in vitro method of releasing a reversibly-linked water-soluble polymer from a protein modified by the water-soluble polymer comprising the step of incubating the protein under conditions effective to release the water-soluble polymer, wherein the conditions comprise increasing free amine concentration of a buffer comprising the protein to a free amine concentration effective to release the water-soluble polymer.
摘要翻译： 本发明涉及在体外释放从由水溶性聚合物，其包含有效地释放所述水溶性聚合物的条件下孵育该蛋白质的步骤修饰的蛋白质的可逆连接的水溶性聚合物的方法，worin条件 包括增加一个缓冲器，其包括该蛋白质以游离胺的浓度有效地释放所述水溶性聚合物的游离胺的浓度。
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