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公开(公告)号：EP2170821A1
公开(公告)日：2010-04-07
申请号：EP08759339.8
申请日：2008-06-25
IPC分类号： C07D207/448
CPC分类号： C07D207/448 , Y02P20/55
摘要： A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)-based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs.
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公开(公告)号：EP2147097A2
公开(公告)日：2010-01-27
申请号：EP08758691.3
申请日：2008-05-21
CPC分类号： C12N9/6454 , B01D15/363 , C12Y304/21075
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3.发明公开RESORPTION ENHANCERS AS ADDITIVES TO IMPROVE THE ORAL FORMULATION OF NON-ANTICOAGULANT SULFATED POLYSACCHARIDES 有权贵重物质补充剂添加剂ZUR VERBESSERUNG DER ORALEN FORMULIERUNG NICHT-ANTIKOAGULIERENDER SULFATIERTER POLYSACCHARIDE
公开(公告)号：EP2734213A2
公开(公告)日：2014-05-28
申请号：EP12814292.4
申请日：2012-07-18
发明人： TURECEK, Peter , VEJDA, Susanne
IPC分类号： A61K31/737 , A61K31/715 , A61K38/17 , A61K31/726 , A61K9/08 , A61K9/10 , A61P1/00
CPC分类号： A61K38/4846 , A61K38/4853 , A61K45/06 , A61K47/12 , A61K47/28 , A61K47/36 , A61K47/42 , A61K2300/00
摘要： Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) in combination with a gastrointestinal epithelial barrier permeation enhancer is orally administered to a subject in a manner sufficient to enhance blood coagulation in the subject. Compositions and kits for practicing methods of the invention are also described.
摘要翻译： 本发明的方面包括用于增强受试者血液凝固的方法。 在根据某些实施方案的实践方法中，以足以增强受试者血液凝固的方式向对象口服施用与胃肠上皮屏障渗透增强剂组合的非抗凝血硫酸多糖（NASP）的量。 还描述了用于本发明的实践方法的组合物和试剂盒。
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4.发明公开METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) 审中-公开用于确定活性成分药物同可释放PEG试剂前体的PEG蛋白质结合物（体外DEPEGYLIERUNG）方法
公开(公告)号：EP2350658A2
公开(公告)日：2011-08-03
申请号：EP09752561.2
申请日：2009-10-20
发明人： VARADI, Katalin , SCHRENK, Gerald , ROTTENSTEINER, Hanspeter , TURECEK, Peter , WEBER, Alfred , ANDERLE, Heinz , CULBERTSON, Sean, M. , FANG, Zhihao , ZAPPE, Harold , ZHANG, Ping , BOSSARD, Mary, J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
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公开(公告)号：EP2247723A1
公开(公告)日：2010-11-10
申请号：EP08868384.2
申请日：2008-12-19
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , A61K38/00 , C12N9/96 , C12Y304/21022
摘要： The present invention discloses a chemically modified FIX, wherein the activation peptide region contains a covalently coupled water-soluble hydrophilic polymer.
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6.发明公开RESORPTION ENHANCERS AS ADDITIVES TO IMPROVE THE ORAL FORMULATION OF LOW MOLECULAR WEIGHT HEPARINS 审中-公开吸收促进剂作为添加剂用于改善LMWH的口头表达能力
公开(公告)号：EP2968400A1
公开(公告)日：2016-01-20
申请号：EP14774362.9
申请日：2014-01-21
发明人： TURECEK, Peter , VEJDA, Susanne
IPC分类号： A61K31/727 , A61P1/04 , A61P1/00
CPC分类号： A61K31/727 , A61K31/722 , A61K38/4873 , A61K45/06 , A61K47/12 , A61K47/28 , A61K47/36 , A61K47/46 , A61K2300/00
摘要： Aspects of the invention include methods for treating or preventing a thromboembolic disease in a subject. In practicing methods according to certain embodiments, an amount of a low molecular weight heparin (LMWH) and a synergistically effective combination of two or more gastrointestinal epithelial barrier permeation enhancers is orally administered to a subject in a manner sufficient to treat the thromboembolic disease in the subject. Compositions and kits for practicing methods of the invention are also described.
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7.发明公开METHODS FOR DIFFERENTIATING PLASMA-DERIVED PROTEIN FROM RECOMBINANT PROTEIN IN A SAMPLE 有权方法分化的蛋白质从血浆中的重组蛋白在样本
公开(公告)号：EP2223108A1
公开(公告)日：2010-09-01
申请号：EP08868946.8
申请日：2008-12-22
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
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8.发明公开FACTOR VIIA- (POLY) SIALIC ACID CONJUGATE HAVING PROLONGED IN VIVO HALF-LIFE 有权凝血因子VIIa（POLY）SIALSÄUREKONJUGAT延长体内半衰期
公开(公告)号：EP2101821A1
公开(公告)日：2009-09-23
申请号：EP07865679.0
申请日：2007-12-14
IPC分类号： A61K47/48
CPC分类号： A61K47/4823 , A61K38/4846 , A61K47/549 , A61K47/61 , C12N9/6437 , C12N9/96 , C12Y304/21021 , Y02A50/463
摘要： The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (F VIIa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVIIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVIII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma.
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公开(公告)号：EP1835938B1
公开(公告)日：2013-08-07
申请号：EP05855442.9
申请日：2005-12-23
CPC分类号： C07K14/755 , A61K47/60 , C07K14/775
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公开(公告)号：EP2349314B1
公开(公告)日：2013-02-27
申请号：EP09740822.3
申请日：2009-10-21
发明人： SCHNECKER, Kurt , HAIDWEGER, Eva , TURECEK, Peter
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