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公开(公告)号：EP2147097A2
公开(公告)日：2010-01-27
申请号：EP08758691.3
申请日：2008-05-21
CPC分类号： C12N9/6454 , B01D15/363 , C12Y304/21075
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2.发明公开METHOD FOR REDUCING THE THROMBOEMBOLIC POTENTIAL OF A PLASMA-DERIVED IMMUNOGLOBULIN COMPOSITION 有权对于血浆的血栓栓塞减轻潜在方法获得的免疫球蛋白组合物
公开(公告)号：EP2748193A1
公开(公告)日：2014-07-02
申请号：EP12768938.8
申请日：2012-08-27
发明人： TESCHNER, Wolfgang , BUTTERWECK, Harald, Arno , KOELBL, Bernhard , HOFBAUER, Lucia , SCHWARZ, Hans-Peter
IPC分类号： C07K16/06
CPC分类号： C07K16/065
摘要： The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
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3.发明公开
公开(公告)号：EP2352820A1
公开(公告)日：2011-08-10
申请号：EP09759839.5
申请日：2009-11-12
发明人： ZAYDENBERG, Alexander , WEBER, Susan , GAVIT, Patrick , LEI, Laura , TESCHNER, Wolfgang , BUTTERWECK, Harald , MAIS-PAUL, Ursula , SCHWARZ, Hans-Peter
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
摘要翻译： 本发明涉及使用阴离子交换材料纯化丁酰胆碱酯酶，其中丁酰胆碱酯酶含量在组合物中富集至少10倍/总蛋白。
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4.发明公开
公开(公告)号：EP1596888A2
公开(公告)日：2005-11-23
申请号：EP04715307.7
申请日：2004-02-27
发明人： ANDERLE, Heinz , MATTHIESSEN, Peter , SCHWARZ, Hans-Peter , TURECEK, Peter , KREIL, Thomas , BOGGS, Daniel, R.
CPC分类号： G01J1/08 , A61L2/0011 , A61L2/0017 , A61L2/0052 , A61L2/10 , A61L2/28 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M2205/053 , C02F1/32 , C02F2201/326 , G01J1/42 , G01J1/48
摘要： A validatable method for determining a photochemically effective dose for inactivating pathogens in a fluid sample is described herein. In particular, the instant invention covers methods for determining a photochemically effective doses sufficient to inactivate pathogens in a biological sample while leaving biologically active substances of interest unaffected. A batch irradiation reactor effective for inactivating pathogens in biological samples is also described.
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公开(公告)号：EP2681553A1
公开(公告)日：2014-01-08
申请号：EP12709015.7
申请日：2012-03-01
CPC分类号： G01N33/50 , G01N33/92 , G01N2400/00
摘要： The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination on the basis of the metal complex of the analyte with a thiocyanate reagent, the complex being extracted in an immiscible organic solvent. The alkaline hydrolysis accounts for the removal of the interfering proteins and enhance selectivity over surfactants similar to the analyte, e.g. for Tween 80 over Triton X-100.
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6.发明公开
公开(公告)号：EP2235188A2
公开(公告)日：2010-10-06
申请号：EP08870385.5
申请日：2008-12-30
发明人： SASGARY, Maria , SCHUSTER, Maria , SCHWARZ, Hans-Peter , REIPERT, Birgit , ANTOINE, Gerhard , EHRLICH, Hartmut
IPC分类号： C12N15/85 , A01K67/027 , C07K14/745 , C07K14/755 , A61K49/00 , G01N33/50 , C12N9/64
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/15 , A01K2227/105 , A01K2267/02 , A01K2267/03 , C07K14/745 , C07K14/755 , C12N9/64
摘要： The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.
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7.发明公开METHODS FOR DIFFERENTIATING PLASMA-DERIVED PROTEIN FROM RECOMBINANT PROTEIN IN A SAMPLE 有权方法分化的蛋白质从血浆中的重组蛋白在样本
公开(公告)号：EP2223108A1
公开(公告)日：2010-09-01
申请号：EP08868946.8
申请日：2008-12-22
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
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8.发明公开IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权趋化因子的IVIG调制多发性硬化症的治疗，老年痴呆症和帕金森氏症
公开(公告)号：EP2191014A2
公开(公告)日：2010-06-02
申请号：EP08785488.1
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing- remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.
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9.发明授权IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE 有权趋化因子的IVIG调制多发性硬化症的治疗，老年痴呆症和帕金森氏症
公开(公告)号：EP2191014B1
公开(公告)日：2013-04-03
申请号：EP08785488.1
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
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10.发明公开A METHOD TO PRODUCE A HIGHLY CONCENTRATED IMMUNOGLOBULIN PREPARATION FOR SUBCUTANEOUS USE 审中-公开一种用于生产高浓度的免疫球蛋白制剂用于皮下使用
公开(公告)号：EP2435474A2
公开(公告)日：2012-04-04
申请号：EP10722883.5
申请日：2010-05-27
发明人： TESCHNER, Wolfgang , BUTTERWECK, Harald Arno , PLJEVLJAKOVIC, Azra , BAUER, Theresa Friederike , KOELBL, Bernhard , SCHWARZ, Hans-Peter , NIKOLIC, Nebojsa , POELSLER, Gerhard , KINDERMANN, Johanna
IPC分类号： C07K16/06
CPC分类号： C07K16/18 , A61K39/39591 , A61K2039/505 , A61K2039/54 , B01D61/142 , B01D61/145 , B01D2315/16 , C07K16/00 , C07K16/065 , C07K2317/10 , C07K2317/21
摘要： The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.
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