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1.发明公开METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) 审中-公开用于确定活性成分药物同可释放PEG试剂前体的PEG蛋白质结合物（体外DEPEGYLIERUNG）方法
公开(公告)号：EP2350658A2
公开(公告)日：2011-08-03
申请号：EP09752561.2
申请日：2009-10-20
发明人： VARADI, Katalin , SCHRENK, Gerald , ROTTENSTEINER, Hanspeter , TURECEK, Peter , WEBER, Alfred , ANDERLE, Heinz , CULBERTSON, Sean, M. , FANG, Zhihao , ZAPPE, Harold , ZHANG, Ping , BOSSARD, Mary, J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
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2.发明公开VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458A2
公开(公告)日：2009-11-11
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
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3.发明授权VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458B1
公开(公告)日：2014-02-26
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
IPC分类号： A61K47/48 , A61P7/00 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60
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公开(公告)号：EP1725262A2
公开(公告)日：2006-11-29
申请号：EP05725666.1
申请日：2005-03-15
IPC分类号： A61K47/00
CPC分类号： A61K47/48215 , A61K47/60
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and administering such conjugates and compositions.
摘要翻译： 本文提供了HIV入口抑制剂的水溶性聚合物缀合物和基于聚合物的组合物。 还提供了用于合成和施用这种缀合物和组合物的方法。
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公开(公告)号：EP2637694A1
公开(公告)日：2013-09-18
申请号：EP11840401.1
申请日：2011-11-11
申请人： Nektar Therapeutics
发明人： BOSSARD, Mary J. , ALI, Cherie F. , LIU, Xiaofeng , CHARYCH, Deborah H. , ZAPPE, Harold , WANG, Yujun , HUANG, Jicai
CPC分类号： A61K47/60 , A61K38/2013 , C07K14/55
摘要： Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.
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公开(公告)号：EP2341942A1
公开(公告)日：2011-07-13
申请号：EP09789327.5
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： BOSSARD, Mary, J. , ROCZNIAK, Steven, O. , ZAPPE, Harold , WANG, Yujun , ZHANG, Ping , SHENG, Dawei , JUDE-FISHBURN, C., Simone , MINAMITANI, Elizabeth , LIU, Xiaofeng , MOSKOWITZ, Haim , FRY, Dennis , ALI, Cherie , BREW, Christine, Taylor
IPC分类号： A61K47/48
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：EP2293818A2
公开(公告)日：2011-03-16
申请号：EP09746991.0
申请日：2009-05-15
申请人： Nektar Therapeutics
IPC分类号： A61K47/48
CPC分类号： A61K47/60
摘要： Conjugates of a cholinesterase moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
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公开(公告)号：EP2344199A1
公开(公告)日：2011-07-20
申请号：EP09789339.0
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： ZAPPE, Harold , BOSSARD, Mary J.
CPC分类号： A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
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公开(公告)号：EP2334334A1
公开(公告)日：2011-06-22
申请号：EP09789330.9
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： ZAPPE, Harold , BOSSARD, Mary, J.
IPC分类号： A61K47/48
摘要： The invention provides nesiritide that is chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of nesiritide not attached to the water-soluble oligomer.
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公开(公告)号：EP2340047A1
公开(公告)日：2011-07-06
申请号：EP09789337.4
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： MINAMITANI, Elizabeth Louise , ZAPPE, Harold , BOSSARD, Mary J. , ROCZNIAK, Steven O. , LIU, Xiaofeng
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
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