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公开(公告)号：EP3700907A1
公开(公告)日：2020-09-02
申请号：EP18785674.5
申请日：2018-10-18
发明人： KOPPITZ, Marcus , SIEBENEICHER, Holger , BRÄUER, Nico , POOK, Elisabeth , ROTGERI, Andrea , NEUHAUS, Roland , FISCHER, Oliver, Martin , NAGEL, Jens , DAVENPORT, Adam, James , CARR, James, Lindsay , TOWNSEND, Robert, James , CONNELLY URSINYOVA, Nina , PARROTT, Shelley, Anne
IPC分类号： C07D487/04 , A61P15/00 , A61P13/00 , A61K31/4985
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公开(公告)号：EP3609869A1
公开(公告)日：2020-02-19
申请号：EP18713989.4
申请日：2018-04-04
发明人： BECK, Hartmut , KAST, Raimund , MEININGHAUS, Mark , DIETZ, Lisa , FÜRSTNER, Chantal , STELLFELD, Timo , ANLAUF, Sonja , VON BÜHLER, Clemens-Jeremias , BAIRLEIN, Michaela , ANLAHR, Johanna , MÜNSTER, Uwe , TERJUNG, Carsten , JÖRISSEN, Hannah , HAUFF, Peter , MÜLLER, Jörg , DRÖBNER, Karoline , NAGEL, Jens
IPC分类号： C07D215/50 , A61K31/47 , A61P11/00 , A61P17/00 , A61P27/02
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公开(公告)号：EP3609870A1
公开(公告)日：2020-02-19
申请号：EP18713990.2
申请日：2018-04-04
发明人： BECK, Hartmut , KAST, Raimund , MEININGHAUS, Mark , FÜRSTNER, Chantal , STELLFELD, Timo , VON BÜHLER, Clemens-Jeremias , DIETZ, Lisa , BAIRLEIN, Michaela , ANLAHR, Johanna , JÖRISSEN, Hannah , HAUFF, Peter , MÜLLER, Jörg , DRÖBNER, Karoline , NAGEL, Jens
IPC分类号： C07D215/50 , A61K31/47 , A61P11/00 , A61P17/00 , A61P27/00
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公开(公告)号：EP3558960A1
公开(公告)日：2019-10-30
申请号：EP17826197.0
申请日：2017-12-18
发明人： BÄURLE, Stefan , DAVENPORT, Adam, James , STIMSON, Christopher , NAGEL, Jens , SCHMIDT, Nicole , ROTGERI, Andrea , GRÖTICKE, Ina , RAUSCH, Alexandra , KLAR, Jürgen , DYRKS, Thomas
IPC分类号： C07D333/58 , C07D231/12 , C07D231/56 , C07D333/28 , C07D333/38 , C07D233/64 , C07D241/12 , C07D495/04 , C07D277/56 , C07D213/56 , A61K31/415 , A61P29/00
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5.发明公开SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF 审中-公开取代的吡啶基 - 环烷基 - 羧酸，含有它们的组合物及其医疗用途
公开(公告)号：EP3233802A1
公开(公告)日：2017-10-25
申请号：EP15810650.0
申请日：2015-12-16
发明人： BRÄUER, Nico , NAGEL, Jens , IRLBACHER, Horst , ROTGERI, Andrea , SCHWEDE, Wolfgang , DAHLLÖF, Henrik , KOPPITZ, Marcus , PETERS, Michaele , GODINHO-COELHO, Anne-Marie
IPC分类号： C07D213/84 , C07D405/12 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , A61K31/4418 , A61P1/00 , A61P15/00 , A61P29/00
CPC分类号： A61K31/167 , A61K31/44 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D405/12
摘要： The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
摘要翻译： 本发明涉及通式（I）的取代的吡啶基 - 环烷基 - 羧酸，涉及包含所述化合物的药物组合物和组合以及涉及所述化合物在制备用于治疗或预防疾病的药物组合物中的用途，特别是 在哺乳动物中，例如与疼痛相关的疾病，或用于治疗或预防疼痛综合征（急性和慢性），炎性诱导疼痛，骨盆疼痛，癌症相关疼痛，子宫内膜异位症相关疼痛以及子宫内膜异位症和子宫腺肌病等 ，癌症本身以及像子宫内膜异位症那样的增殖性疾病。
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公开(公告)号：EP2928884B1
公开(公告)日：2017-05-24
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
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公开(公告)号：EP3083603B1
公开(公告)日：2017-09-13
申请号：EP14814837.2
申请日：2014-12-16
发明人： PETERS, Olaf , BRÄUER, Nico , BOTHE, Ulrich , KOPPITZ, Marcus , NAGEL, Jens , LANGER, Gernot
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D403/04 , A61K45/06
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公开(公告)号：EP3083603A1
公开(公告)日：2016-10-26
申请号：EP14814837.2
申请日：2014-12-16
发明人： PETERS, Olaf , BRÄUER, Nico , BOTHE, Ulrich , KOPPITZ, Marcus , NAGEL, Jens , LANGER, Gernot
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D403/04 , A61K45/06
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), to methods for preparation thereof and to the use thereof for producing pharmaceutical compositions for treating disorders and indications associated with the EP4 receptor.
摘要翻译： 本发明涉及通式（I）的新型苯并咪唑衍生物，其制备方法及其用于制备用于治疗与EP4受体相关的疾病和适应症的药物组合物。
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公开(公告)号：EP3558972A1
公开(公告)日：2019-10-30
申请号：EP17832944.7
申请日：2017-12-18
发明人： BÄURLE, Stefan , DAVENPORT, Adam, James , STIMSON, Christopher , CARR, James, Lindsay , BUBERT, Christian, , MARLIN, Frédéric, Jacques , NAGEL, Jens , SCHMIDT, Nicole , ROTGERI, Andrea , IRLBACHER, Horst
IPC分类号： C07D401/14 , C07D401/10 , C07D403/10 , C07D257/04 , A61K31/41 , A61P29/00
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公开(公告)号：EP2928884A1
公开(公告)日：2015-10-14
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
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