-
公开(公告)号：EP3580211B1
公开(公告)日：2020-12-02
申请号：EP18703958.1
申请日：2018-02-02
发明人： GUTCHER, Ilona , RÖHN, Ulrike , SCHMEES, Norbert , ZORN, Ludwig , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , IRLBACHER, Horst , PLATTEN, Michael
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D237/04 , C07D237/24 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/501 , A61P35/00
-
公开(公告)号：EP3713931A1
公开(公告)日：2020-09-30
申请号：EP18800218.2
申请日：2018-11-16
发明人： GUTCHER, Ilona , RÖHN, Ulrike , ZORN, Ludwig , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , PLATTEN, Michael
IPC分类号： C07D403/12 , C07D237/16 , C07D237/20 , C07D405/12 , A61P35/00 , A61K31/501
-
公开(公告)号：EP3713923A1
公开(公告)日：2020-09-30
申请号：EP18800220.8
申请日：2018-11-16
发明人： LEFRANC, Julien , SCHMEES, Norbert , RÖHN, Ulrike , ZORN, Ludwig , GÜNTHER, Judith , GUTCHER, Ilona , RÖSE, Lars , BADER, Benjamin , STÖCKIGT, Detlef , PLATTEN, Michael
IPC分类号： C07D239/28 , C07D405/12 , A61P35/00 , A61K31/505
-
公开(公告)号：EP3713922A1
公开(公告)日：2020-09-30
申请号：EP18800217.4
申请日：2018-11-16
发明人： ZORN, Ludwig , RÖHN, Ulrike , GUTCHER, Ilona , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , PLATTEN, Michael
IPC分类号： C07D237/16 , C07D237/20 , A61P35/00 , A61K31/501
-
公开(公告)号：EP4100515A1
公开(公告)日：2022-12-14
申请号：EP21703395.0
申请日：2021-02-01
-
公开(公告)号：EP4013508A1
公开(公告)日：2022-06-22
申请号：EP20761758.0
申请日：2020-08-10
发明人： LEFRANC, Julien , SCHMEES, Norbert , ZORN, Ludwig , MEIER, Robin Michael , HERBERT, Simon Anthony , GÜNTHER, Judith , GUTCHER, Ilona , RÖSE, Lars , BADER, Benjamin , STÖCKIGT, Detlef , GORJÁNÁCZ, Mátyás , KOBER, Christina , BUCHMANN, Bernd , BÖHME, Stephan , BOTHE, Ulrich , PLATTEN, Michael , BAUMANN, Daniel
IPC分类号： A61P35/00 , C07D487/04 , C07D519/00
-
公开(公告)号：EP3580211A1
公开(公告)日：2019-12-18
申请号：EP18703958.1
申请日：2018-02-02
发明人： GUTCHER, Ilona , RÖHN, Ulrike , SCHMEES, Norbert , ZORN, Ludwig , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , IRLBACHER, Horst , PLATTEN, Michael
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D237/04 , C07D237/24 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/501 , A61P35/00
-
公开(公告)号：EP3713926A1
公开(公告)日：2020-09-30
申请号：EP18800216.6
申请日：2018-11-16
发明人： LEFRANC, Julien , SCHMEES, Norbert , RÖHN, Ulrike , ZORN, Ludwig , GÜNTHER, Judith , GUTCHER, Ilona , RÖSE, Lars , BADER, Benjamin , STÖCKIGT, Detlef , PLATTEN, Michael
IPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , A61K31/506 , A61P35/00
-
公开(公告)号：EP3325451B1
公开(公告)日：2019-07-10
申请号：EP16757565.3
申请日：2016-07-14
发明人： PANKNIN, Olaf , HARTUNG, Ingo , REHWINKEL, Hartmut , NGUYEN, Duy , ZORN, Ludwig , HELFRICH, Petra , ZIMMERMANN, Katja , NEUHAUS, Roland
IPC分类号： C07D235/30 , C07D471/04 , A61P35/00 , A61K31/437 , A61K31/4184
-
10.发明公开3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的3-氨基甲酰基苯基-4-甲酰胺和异鼠李素衍生物
公开(公告)号：EP3259263A1
公开(公告)日：2017-12-27
申请号：EP16704456.9
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William j. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D401/14 , C07D213/73 , C07D213/75 , C07D401/12 , A61K31/435 , A61P35/00 , C07C15/04
CPC分类号： A61K31/435 , C07C237/44 , C07D213/73 , C07D213/75 , C07D401/12 , C07D401/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.03 秒)
