公开(公告)号：EP1644339A1

公开(公告)日：2006-04-12

申请号：EP04739944.9

申请日：2004-06-16

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÄRFACKER, Lars ,  BEYREUTHER, Bettina ,  EBERT, Ulrich ,  ERB, Christina ,  HAFNER, Frank-Thorsten ,  HECKROTH, Heike ,  LIU, Yan-Hong ,  KARTHAUS , Dagmar ,  TERSTEEGEN, Adrian ,  VAN DER STAAY, Franz-Josef ,  VAN KAMPEN, Marja

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D409/12 ,  A61K31/505 ,  A61K31/506 ,  A61P25/28

CPC分类号： C07D239/42 ,  C07D401/12 ,  C07D409/12

摘要： The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I), methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.

公开(公告)号：EP1677786A1

公开(公告)日：2006-07-12

申请号：EP04790125.1

申请日：2004-10-05

申请人： Bayer HealthCare AG

发明人： BAUSER, Marcus ,  KRÜGER, Joachim ,  MEIER, Heinrich ,  VÖHRINGER, Verena ,  BEYREUTHER, Bettina ,  MOGI, Muneto ,  MARUMO, Makiko ,  TSUNO, Naoki ,  SHIMIZU, Haruka ,  FUJISHIMA, Hiroshi ,  YUASA, Hiroaki ,  HAYASHI, Mayumi ,  UMEDA, Masaomi ,  IWATA, Atsuko

IPC分类号： A61K31/4196 ,  C07D249/12 ,  C07D401/04 ,  A61P13/10

CPC分类号： C07D401/10 ,  C04B35/632 ,  C07D249/12 ,  C07D401/12 ,  C07D403/10

摘要： This invention relates to phenyltriazole derivatives of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations : (I) wherein R1 represents alkyl optionally substituted or 3-8 membered saturated or unsaturated ring optionally substituted, R2 represents -COR21, -(CH2)n-R21 or tert-butyl, X represents CR10R11, NR12, S, O, SO2, or SO wherein R10, R11 and R12 independently represent hydrogen or methyl. The other substituents are as defined in the claims. The phenyltriazole derivatives of the present invention have an excellent activity as GABAb agonist and are useful for the prophylaxis and treatment of diseases associated with GABAb activity, in particular for the treatment of overactive bladder, urinary incontinence such as urge urinary incontinence, benign prostatic hyperplasia (BPH), chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, or nerve injury.