公开(公告)号：EP1709009A1

公开(公告)日：2006-10-11

申请号：EP04804457.2

申请日：2004-12-31

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÄRFACKER, Lars ,  HECKROTH, Heike ,  KARTHAUS, Dagmar ,  TERSTEEGEN, Adrian

IPC分类号： C07D239/47 ,  C07D403/04 ,  C07D409/06 ,  C07D409/14 ,  A61K31/513 ,  A61P25/28

CPC分类号： C07D239/47 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D491/10

摘要： The invention relates to novel cyanopyrimidinones, methods for the production thereof, and the use thereof for producing medicaments used for improving perception, power of concentration, learning efficiency, and/or memory capacity.

公开(公告)号：EP1161423B1

公开(公告)日：2004-11-10

申请号：EP00907614.2

申请日：2000-02-24

申请人： Bayer HealthCare AG

发明人： FISCHER, Rüdiger ,  KLEYMANN, Gerald ,  BAUMEISTER, Judith ,  BENDER, Wolfgang ,  BETZ, Ulrich ,  ECKENBERG, Peter ,  HANDKE, Gabriele ,  HENDRIX, Martin ,  SCHNEIDER, Udo ,  WEBER, Olaf ,  HENNINGER, Kerstin ,  JENSEN, Axel ,  KELDENICH, Jörg

IPC分类号： C07D277/54 ,  C07D417/12 ,  C07D487/04 ,  A61K31/426 ,  A61K31/427 ,  A61P31/12

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/54 ,  C07D417/12 ,  C07D487/04

公开(公告)号：EP1461335A1

公开(公告)日：2004-09-29

申请号：EP02793023.9

申请日：2002-12-16

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS , Frank-Gerhard ,  ERB, Christina ,  FLESSNER, Timo ,  VAN KAMPEN, Marja ,  LUITHLE, Joachim ,  METHFESSEL, Christoph ,  WIESE, Welf, Burkhard

IPC分类号： C07D453/02 ,  C07D519/00 ,  A61K31/435

CPC分类号： C07D453/02

摘要： The invention relates to novel 2-heteroarylcarboxylic acid amides, methods for the production thereof in addition to the use thereof for the production of medicaments for the treatment and/or the prophylaxis of illnesses and for the improvement of perception, concentration power, learning power and/or memory power.

公开(公告)号：EP1448530A1

公开(公告)日：2004-08-25

申请号：EP02781305.4

申请日：2002-11-06

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  KRÜGER, Joachim ,  LUITHLE, Joachim ,  METHFESSEL, Christoph ,  SCHREIBER, Rudy ,  WIESE, Welf-Burkhard

IPC分类号： C07D215/48 ,  C07D241/46 ,  C07D453/02 ,  A61P25/28 ,  A61K31/47 ,  A61K31/517

CPC分类号： C07D453/02

摘要： The invention relates to novel heteroaryl carboxylic acid amides, a method for producing the same and the use thereof for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learning ability and/or memory power.

公开(公告)号：EP1404677A1

公开(公告)日：2004-04-07

申请号：EP02747362.8

申请日：2002-06-10

申请人： Bayer HealthCare AG

发明人： ERGÜDEN, Jens-Kerim ,  BAUSER, Marcus ,  BURKHARDT, Nils ,  FLUBACHER, Dietmar ,  FRIEDL, Arno ,  GERLACH, Irene ,  HINZ, Volker ,  JORK, Reinhard ,  NAAB, Paul ,  NIEWÖHNER, Maria Theresia ,  REPP, Thorsten, Oliver ,  SCHLEMMER, Karl-Heinz ,  STOLTEFUSS, Jürgen ,  BRÜCKNER, David ,  HENDRIX, Martin ,  SCHAUSS, Dagmar ,  TERSTEEGEN, Adrian

IPC分类号： C07D487/04 ,  A61K31/415 ,  A61K31/53 ,  A61P25/28

CPC分类号： C07D487/04

摘要： The invention relates to the novel imidazotriazines of general formula (I), to methods for their production, and to the use thereof for producing drugs for the treatment and/or the prophylaxis of neurodegenerative diseases, especially Parkinson's disease.

公开(公告)号：EP1399447A1

公开(公告)日：2004-03-24

申请号：EP02743040.4

申请日：2002-05-17

申请人： Bayer HealthCare AG

发明人： ALONSO-ALIJA, Cristina ,  GIELEN, Heike ,  HENDRIX, Martin ,  NIEWÖHNER, Ulrich ,  SCHAUSS, Dagmar ,  BISCHOFF, Hilmar ,  BURKHARDT, Nils ,  GEISS, Volker ,  SCHLEMMER, Karl-Heinz ,  CUTHBERT, Nigel, J. ,  FITZGERALD, Mary ,  STURTON, Graham

IPC分类号： C07D487/04 ,  A61K31/53

CPC分类号： C07D253/07 ,  C07D487/04

摘要： The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

公开(公告)号：EP2079708A2

公开(公告)日：2009-07-22

申请号：EP07818862.0

申请日：2007-10-10

申请人： Bayer HealthCare AG

发明人： BAUSER, Marcus ,  BUCHMÜLLER, Anja ,  VON DEGENFELD, Georges ,  DITTRICH-WENGENROTH, Elke ,  GERDES, Christoph ,  GNOTH, Mark, Jean ,  GOTTSCHLING, Dirk ,  HEITMEIER, Stefan ,  HENDRIX, Martin ,  KÖBBERLING, Johannes ,  LANG, Dieter ,  RESTER, Ulrich ,  SAATMANN, Uwe ,  TERSTEEGEN, Adrian ,  BRÜNS, Astrid

IPC分类号： C07D233/88

CPC分类号： C07D233/88 ,  C07D277/20 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： The invention relates to acyl aminoimidazoles and acyl aminothiazoles, to a method for producing same and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular cardiovascular diseases, preferably thromboembolic diseases.

摘要翻译： 本发明涉及酰基氨基咪唑和酰基氨基噻唑，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓栓塞性疾病的药物。

公开(公告)号：EP1888076A1

公开(公告)日：2008-02-20

申请号：EP06753634.2

申请日：2006-05-16

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  WUNDER, Frank ,  TERSTEEGEN, Adrian ,  STASCH, Johannes-Peter ,  WUTTKE, Martina

IPC分类号： A61K31/519 ,  A61P9/10

CPC分类号： A61K31/519

摘要： The invention relates to the use of pyrazolopyrimidine for producing drugs for treating cardiovascular diseases.

公开(公告)号：EP1399439B1

公开(公告)日：2006-06-14

申请号：EP02730265.2

申请日：2002-05-21

申请人： Bayer HealthCare AG

发明人： ALONSO-ALIJA, Cristina ,  GIELEN, Heike ,  HENDRIX, Martin ,  NIEWÖHNER, Ulrich ,  SCHAUSS, Dagmar ,  BISCHOFF, Hilmar ,  BURKHARDT, Nils ,  GEISS, Volker ,  SCHLEMMER, Karl-Heinz ,  CUTHBERT,Nigel ,  Cuthbert, Nigel ,  Fitzgerald, Mary.F. ,  Sturton, Graham. ,  NIEWÖHNER, Maria, Theresia

IPC分类号： C07D409/04 ,  C07D417/04 ,  C07D401/04 ,  C07D407/04 ,  C07D403/04 ,  C07D487/04 ,  A61K31/53 ,  A61P37/00 ,  A61P29/00 ,  A61P11/00 ,  A61P11/06

CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D487/04

摘要： The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C¿1?-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.

公开(公告)号：EP1534713A1

公开(公告)日：2005-06-01

申请号：EP03797239.5

申请日：2003-08-13

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  BURKHARDT, Nils ,  ERB, Christina ,  TERSTEEGEN, Adrian ,  VAN KAMPEN, Marja

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, methods for the production thereof, and the use thereof for producing medicaments which improve awareness, concentration, learning capacity, and/or memory performance.