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公开(公告)号：EP1458716B1
公开(公告)日：2006-09-27
申请号：EP02787913.9
申请日：2002-12-06
申请人： Bayer HealthCare AG
发明人： LUITHLE, Joachim , BÖSS, Frank-Gerhard , ERB, Christina , FLESSNER, Timo , HENDRIX, Martin , VAN KAMPEN, Marja , METHFESSEL, Christoph
IPC分类号： C07D453/02 , A61K31/435 , A61P25/28
CPC分类号： A61K31/435 , C07D453/02
摘要： The invention relates to novel bicyclic N-arylamides, to a method for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learning capacity and/or memory retention.
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2.发明授权BENZOTHIOPHEN-, BENZOFURAN- UND INDOLHARNSTOFFE UND DEREN VERWENDUNG ALS ALPHA7-ACHR AGONISTEN 有权苯并噻吩，苯并呋喃和INDOLHARNSTOFFE及其作为alpha7- ACHR激动剂
公开(公告)号：EP1527073B1
公开(公告)日：2007-08-22
申请号：EP03766162.6
申请日：2003-07-14
申请人： Bayer HealthCare AG
发明人： FLESSNER, Timo , BÖSS, Frank-Gerhard , ERB, Christina , HAFNER, Frank-Thorsten , SCHNIZLER, Katrin , LANG, Dieter , LUITHLE, Joachim , VAN KAMPEN, Marja , VAN DER STAAY, Franz-Josef
IPC分类号： C07D453/02 , A61K31/439 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, learning capacity and/or memory retention.
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公开(公告)号：EP1461335B1
公开(公告)日：2007-02-28
申请号：EP02793023.9
申请日：2002-12-16
申请人： Bayer HealthCare AG
发明人： HENDRIX, Martin , BÖSS , Frank-Gerhard , ERB, Christina , FLESSNER, Timo , VAN KAMPEN, Marja , LUITHLE, Joachim , METHFESSEL, Christoph , WIESE, Welf-Burkhard
IPC分类号： C07D453/02 , C07D519/00 , A61K31/435
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxylic acid amides, methods for the production thereof in addition to the use thereof for the production of medicaments for the treatment and/or the prophylaxis of illnesses and for the improvement of perception, concentration power, learning power and/or memory power.
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4.发明公开AMID-SUBSTITUIERTE 1, 2, 4-TRIAZIN-5 (2H) - ONE ZUR BEHANDLUNG VON CHRONISCH INFLAMMATORISCHEN KRANKHEITEN 审中-公开酰胺取代的1，2，4-三嗪-5（2H） - 酮用于治疗慢性炎症性疾病治疗
公开(公告)号：EP1644353A1
公开(公告)日：2006-04-12
申请号：EP04737078.8
申请日：2004-06-21
申请人： Bayer HealthCare AG
发明人： FLESSNER, Timo , HENNINGER, Kerstin , RAABE, Martin , WOLTERING, Elisabeth , ZAISS, Siegfried , ZIMMERMANN, Katja , ZUMPE, Franz , KARIG, Gunter , HENDRIX, Martin , WEBER, Olaf , KARTHAUS, Dagmar
IPC分类号： C07D401/12 , A61K31/53 , C07D413/12 , C07D417/12 , C07D403/12 , C07D409/12 , A61P29/00
CPC分类号： C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to amide-substituted 1,2,4-triazin-5(2H)-ones, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially chronically inflammatory diseases such as rheumatoid diseases, and cardiovascular diseases such as dyslipidemia, arteriosclerosis and coronary heart diseases Formula (I).
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公开(公告)号：EP1515967A1
公开(公告)日：2005-03-23
申请号：EP03732517.2
申请日：2003-06-02
申请人： Bayer HealthCare AG
发明人： LUITHLE, Joachim , BÖSS, Frank-Gerhard , ERB, Christina , HAFNER, Frank-Thorsten , SCHNIZLER, Katrin , FLESSNER, Timo , VAN KAMPEN, Marja , VAN DER STAAY, Franz-Josef
IPC分类号： C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D453/02
摘要： The invention relates to the novel 2-heteroaryl carboxamides according to formula (I), wherein R represents 1-aza-bicyclo [2.2.2]oct-3-yl, which is optionally replaced via the nitrogen atom by a group selected from the family C1-C4 alkyl, benzyl and oxy, A represents oxygen or sulfur, the ring B represents benzo or pyrido that are optionally replaced by the groups from the family of halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkyl and C1-C6 alkoxy, E represents C=C, aryl and heteroaryl, wherein aryl and heteroaryl may be replaced by groups from the family of halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkoxy and C1-C6 alkyl, and to the solvents, salts or solvents of salts of said compounds. The invention also relates to the use of said compounds in the production of drugs for the treatment and/or the prophylaxis of diseases and for improving perception, power of concentration, learning power and/or retentiveness of memory.
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6.发明授权TETRAHYDROBENZO (D) AZEPIN-2-ON DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KARDIOVASKULÄREN KRANKHEITEN 有权四氢苯并（D）氮杂-2-酮衍生物及其用于治疗心血管疾病的治疗
公开(公告)号：EP1716118B1
公开(公告)日：2008-04-30
申请号：EP05701287.4
申请日：2005-02-01
申请人： Bayer HealthCare AG
发明人： GRIEBENOW, Nils , FLESSNER, Timo , HÄRTER, Michael , RAABE, Martin , BUCHMÜLLER, Anja , BISCHOFF, Hilmar , ELLINGHAUS, Peter , KOLKHOF, Peter
IPC分类号： C07D223/16 , C07D401/06 , A61K31/55 , A61P9/00
CPC分类号： C07D223/16 , C07D401/06
摘要： The invention concerns novel tetrahydrobenzo[d]azepin-2-one derivatives, a method for the production thereof, their use for treating and/or preventing diseases, and their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, particularly dyslipidemias, arteriosclerosis, restenosis and ischemias.
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公开(公告)号：EP1651645B1
公开(公告)日：2007-02-21
申请号：EP04741132.7
申请日：2004-07-19
申请人： Bayer HealthCare AG
发明人： FLESSNER, Timo , BÖSS, Frank-Gerhard , HAFNER, Frank-Thorsten , LUITHLE, Joachim , METHFESSEL, Christoph , TELAN, Leila
IPC分类号： C07D453/02
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.
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公开(公告)号：EP1487835B1
公开(公告)日：2006-09-20
申请号：EP03744337.1
申请日：2003-03-03
申请人： Bayer HealthCare AG
发明人： LUITHLE, Joachim , BÖSS, Frank-Gerhard , ERB, Christina , SCHNITZLER, Katrin , FLESSNER, Timo , VAN KAMPEN, Marja , METHFESSEL, Christoph
IPC分类号： C07D453/02 , A61K31/439 , A61P25/28
CPC分类号： C07D453/02 , A61K31/439 , C07D453/04
摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
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9.发明公开BENZOTHIOPHEN-, BENZOFURAN- UND INDOLHARNSTOFFE UND DEREN VERWENDUNG ALS ALPHA7-ACHR AGONISTEN 有权苯并噻吩，苯并呋喃和INDOLHARNSTOFFE及其作为alpha7- ACHR激动剂
公开(公告)号：EP1527073A1
公开(公告)日：2005-05-04
申请号：EP03766162.6
申请日：2003-07-14
申请人： Bayer HealthCare AG
发明人： FLESSNER, Timo , BÖSS, Frank-Gerhard , ERB, Christina , HAFNER, Frank-Thorsten , SCHNIZLER, Katrin , LANG, Dieter , LUITHLE, Joachim , VAN KAMPEN, Marja , VAN DER STAAY, Franz-Josef
IPC分类号： C07D453/02 , A61K31/439 , A61P25/28
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, learning capacity and/or memory retention.
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公开(公告)号：EP1461335A1
公开(公告)日：2004-09-29
申请号：EP02793023.9
申请日：2002-12-16
申请人： Bayer HealthCare AG
发明人： HENDRIX, Martin , BÖSS , Frank-Gerhard , ERB, Christina , FLESSNER, Timo , VAN KAMPEN, Marja , LUITHLE, Joachim , METHFESSEL, Christoph , WIESE, Welf, Burkhard
IPC分类号： C07D453/02 , C07D519/00 , A61K31/435
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroarylcarboxylic acid amides, methods for the production thereof in addition to the use thereof for the production of medicaments for the treatment and/or the prophylaxis of illnesses and for the improvement of perception, concentration power, learning power and/or memory power.
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