公开(公告)号：EP1534713A1

公开(公告)日：2005-06-01

申请号：EP03797239.5

申请日：2003-08-13

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  BURKHARDT, Nils ,  ERB, Christina ,  TERSTEEGEN, Adrian ,  VAN KAMPEN, Marja

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, methods for the production thereof, and the use thereof for producing medicaments which improve awareness, concentration, learning capacity, and/or memory performance.

公开(公告)号：EP1448530B1

公开(公告)日：2007-10-03

申请号：EP02781305.4

申请日：2002-11-06

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  KRÜGER, Joachim ,  LUITHLE, Joachim ,  METHFESSEL, Christoph ,  SCHREIBER, Rudy ,  WIESE, Welf-Burkhard

IPC分类号： C07D215/48 ,  C07D241/46 ,  C07D453/02 ,  A61P25/28 ,  A61K31/47 ,  A61K31/517

CPC分类号： C07D453/02

摘要： The invention relates to novel heteroaryl carboxylic acid amides, a method for producing the same and the use thereof for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learning ability and/or memory power.

公开(公告)号：EP1527073B1

公开(公告)日：2007-08-22

申请号：EP03766162.6

申请日：2003-07-14

申请人： Bayer HealthCare AG

发明人： FLESSNER, Timo ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  HAFNER, Frank-Thorsten ,  SCHNIZLER, Katrin ,  LANG, Dieter ,  LUITHLE, Joachim ,  VAN KAMPEN, Marja ,  VAN DER STAAY, Franz-Josef

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/28

CPC分类号： C07D453/02

摘要： The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, learning capacity and/or memory retention.

公开(公告)号：EP1363912B1

公开(公告)日：2006-05-24

申请号：EP02704706.7

申请日：2002-02-11

申请人： Bayer HealthCare AG

发明人： NIEWÖHNER, Ulrich ,  SCHAUSS, Dagmar ,  KÖNIG, Gerhard ,  HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  VAN DER STAAY, Franz-Josef ,  SCHREIBER, Rudy ,  SCHLEMMER, Karl-Heinz ,  MORIWAKI, Toshiya ,  NIEWÖHNER, Maria Theresia

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P25/00 ,  C07D253/06 ,  C07D253/00 ,  C07D235/00

CPC分类号： C07D253/07 ,  C07D487/04

摘要： The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness.

摘要翻译： 本发明涉及新型取代的咪唑并三嗪酮，其制备方法及其用于制备药物的用途，特别是改善知觉，注意力，学习能力和/或记忆保持力的能力。

公开(公告)号：EP1515967A1

公开(公告)日：2005-03-23

申请号：EP03732517.2

申请日：2003-06-02

申请人： Bayer HealthCare AG

发明人： LUITHLE, Joachim ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  HAFNER, Frank-Thorsten ,  SCHNIZLER, Katrin ,  FLESSNER, Timo ,  VAN KAMPEN, Marja ,  VAN DER STAAY, Franz-Josef

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

CPC分类号： C07D453/02

摘要： The invention relates to the novel 2-heteroaryl carboxamides according to formula (I), wherein R represents 1-aza-bicyclo [2.2.2]oct-3-yl, which is optionally replaced via the nitrogen atom by a group selected from the family C1-C4 alkyl, benzyl and oxy, A represents oxygen or sulfur, the ring B represents benzo or pyrido that are optionally replaced by the groups from the family of halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkyl and C1-C6 alkoxy, E represents C=C, aryl and heteroaryl, wherein aryl and heteroaryl may be replaced by groups from the family of halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkoxy and C1-C6 alkyl, and to the solvents, salts or solvents of salts of said compounds. The invention also relates to the use of said compounds in the production of drugs for the treatment and/or the prophylaxis of diseases and for improving perception, power of concentration, learning power and/or retentiveness of memory.

公开(公告)号：EP1651645B1

公开(公告)日：2007-02-21

申请号：EP04741132.7

申请日：2004-07-19

申请人： Bayer HealthCare AG

发明人： FLESSNER, Timo ,  BÖSS, Frank-Gerhard ,  HAFNER, Frank-Thorsten ,  LUITHLE, Joachim ,  METHFESSEL, Christoph ,  TELAN, Leila

IPC分类号： C07D453/02

CPC分类号： A61K31/439 ,  A61K45/06 ,  C07D453/02

摘要： The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.

公开(公告)号：EP1487835B1

公开(公告)日：2006-09-20

申请号：EP03744337.1

申请日：2003-03-03

申请人： Bayer HealthCare AG

发明人： LUITHLE, Joachim ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  SCHNITZLER, Katrin ,  FLESSNER, Timo ,  VAN KAMPEN, Marja ,  METHFESSEL, Christoph

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/28

CPC分类号： C07D453/02 ,  A61K31/439 ,  C07D453/04

摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.

公开(公告)号：EP1527073A1

公开(公告)日：2005-05-04

申请号：EP03766162.6

申请日：2003-07-14

申请人： Bayer HealthCare AG

发明人： FLESSNER, Timo ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  HAFNER, Frank-Thorsten ,  SCHNIZLER, Katrin ,  LANG, Dieter ,  LUITHLE, Joachim ,  VAN KAMPEN, Marja ,  VAN DER STAAY, Franz-Josef

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/28

CPC分类号： C07D453/02

摘要： The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, learning capacity and/or memory retention.

公开(公告)号：EP1448530A1

公开(公告)日：2004-08-25

申请号：EP02781305.4

申请日：2002-11-06

申请人： Bayer HealthCare AG

发明人： HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  KRÜGER, Joachim ,  LUITHLE, Joachim ,  METHFESSEL, Christoph ,  SCHREIBER, Rudy ,  WIESE, Welf-Burkhard

IPC分类号： C07D215/48 ,  C07D241/46 ,  C07D453/02 ,  A61P25/28 ,  A61K31/47 ,  A61K31/517

CPC分类号： C07D453/02

摘要： The invention relates to novel heteroaryl carboxylic acid amides, a method for producing the same and the use thereof for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learning ability and/or memory power.

公开(公告)号：EP1458716B1

公开(公告)日：2006-09-27

申请号：EP02787913.9

申请日：2002-12-06

申请人： Bayer HealthCare AG

发明人： LUITHLE, Joachim ,  BÖSS, Frank-Gerhard ,  ERB, Christina ,  FLESSNER, Timo ,  HENDRIX, Martin ,  VAN KAMPEN, Marja ,  METHFESSEL, Christoph

IPC分类号： C07D453/02 ,  A61K31/435 ,  A61P25/28

CPC分类号： A61K31/435 ,  C07D453/02

摘要： The invention relates to novel bicyclic N-arylamides, to a method for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of diseases and for improving perception, power of concentration, learning capacity and/or memory retention.