公开(公告)号：EP0993446B1

公开(公告)日：2004-11-03

申请号：EP98939502.5

申请日：1998-06-15

申请人： Bayer HealthCare AG

发明人： BERWE, Mathias ,  DIEHL, Herbert ,  RITTNER, Karl ,  WAHL, Karl-Heinz ,  WIRGES, Hans-Peter

IPC分类号： C07D211/90

CPC分类号： A61K31/4422 ,  C07D211/90

摘要： A process is disclosed for preparing nifedipine by reacting 2-(2-nitrobenzylidene)acetic acid methyl ester and 3-aminocrotonic acid methyl ester, as well as the use of the thus prepared nifedipine for producing a medicament.

公开(公告)号：EP1345939B1

公开(公告)日：2006-06-07

申请号：EP01271374.9

申请日：2001-12-05

申请人： Bayer HealthCare AG

发明人： NOWAKOWSKI, Marc ,  GEHRING, Reinhold ,  HEILMANN, Werner ,  WAHL, Karl-Heinz

IPC分类号： C07D487/04 ,  C07D253/00 ,  C07D235/00

CPC分类号： C07D487/04

摘要： The invention relates to a method for producing sulfonamide-substituted imidazotriazinones of the general formula (I). The inventive method is characterized by reacting the compounds of formula (II) with sulfuric acid and then reacting the products obtained with thionylchloride and in situ in an inert solvent with an amine to give the compounds according to the invention or optionally the corresponding salts, hydrates or N-oxides.