公开(公告)号：EP1326856B1

公开(公告)日：2007-12-19

申请号：EP01969704.4

申请日：2001-09-10

申请人： Bayer HealthCare AG

发明人： LOWINGER, Timothy, B. ,  MURATA, Toshiki ,  UMEDA, Masaomi ,  SAKAKIBARA, Sachiko ,  YOSHINO, Takashi ,  SATO, Hiroki ,  MASUDA, Tsutomu ,  KORIYAMA, Yuji ,  SHIMADA, Mitsuyuki ,  SHINTANI, Takuya ,  KADONO, Hiroshi ,  ZIEGELBAUER, Karl, B. ,  FUCHIKAMI, Kinji ,  KOMURA, Hiroshi

IPC分类号： C07D401/04 ,  C07D213/85 ,  C07D401/14 ,  C07D409/14 ,  C07D401/06 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04 ,  A61P17/00 ,  A61P11/06 ,  A61P29/00 ,  A61K31/4427 ,  A61K31/4353 ,  C07D471/18 ,  C07D498/04 ,  C07D213/80 ,  C07D213/73 ,  C07D521/00 ,  C07D513/04

CPC分类号： C07D213/08 ,  C07D213/10 ,  C07D213/73 ,  C07D213/80 ,  C07D213/85 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  C07D513/04 ,  C07D515/04

摘要： Pyridine compounds of general formula (I) wherein -R1 represents, or in which R11 is hydrogen, C¿1-6? alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or -O-(CH2)n-R?111 ; R2¿ represents hydrogen or halogen; R3 represents hydrogen, -CR?31R32R33¿, or -NR?34R35; R4¿ is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C¿1-6? alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.