公开(公告)号：EP0993446B1

公开(公告)日：2004-11-03

申请号：EP98939502.5

申请日：1998-06-15

申请人： Bayer HealthCare AG

发明人： BERWE, Mathias ,  DIEHL, Herbert ,  RITTNER, Karl ,  WAHL, Karl-Heinz ,  WIRGES, Hans-Peter

IPC分类号： C07D211/90

CPC分类号： A61K31/4422 ,  C07D211/90

摘要： A process is disclosed for preparing nifedipine by reacting 2-(2-nitrobenzylidene)acetic acid methyl ester and 3-aminocrotonic acid methyl ester, as well as the use of the thus prepared nifedipine for producing a medicament.

公开(公告)号：EP1365737B1

公开(公告)日：2005-04-20

申请号：EP01956511.8

申请日：2001-07-05

申请人： Bayer HealthCare AG

发明人： FRANCKOWIAK, Gerhard ,  APPOLT, Hubert ,  LEIFKER, Gregor ,  WIRGES, Hans-Peter ,  LEDWOCH, Wolfram

IPC分类号： C07C229/26 ,  C07C69/157 ,  A61K31/616 ,  A61P19/02 ,  A61P25/06

CPC分类号： A61K31/616 ,  C07C229/26

摘要： The invention relates to stable salts of o-acetylsalicyclic acid with basic amino acids, to a method for producing them and to their use as medicaments.