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1.发明公开
公开(公告)号：EP3411037A1
公开(公告)日：2018-12-12
申请号：EP17704195.1
申请日：2017-02-03
申请人： Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana Farber Cancer Institute, Inc.
发明人： WENGNER, Antje, Margret , EIS, Knut , LIENAU, Philip , SACK, Ulrike , LANGE, Martin , GREULICH, Heidi , MEYERSON, Matthew , DE WAAL, Luc , SCHENONE, Monica , BURGIN, Alex , LEWIS, Timothy, A. , WU, Xiaoyun
IPC分类号： A61K31/50 , A61K31/5375 , A61K45/00 , G01N33/68 , A61P35/00
CPC分类号： A61K31/50 , A61K31/5375 , A61P35/00 , G01N33/68 , G01N2333/4703 , G01N2333/916 , G01N2800/52
摘要： The present invention features improved Compounds, especially (I) methods of identifying patients having Cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3Ll) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
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公开(公告)号：EP3710448A1
公开(公告)日：2020-09-23
申请号：EP18808247.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , LEMKE, Chris , SERRANO-WU, Michael, H. , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710447A1
公开(公告)日：2020-09-23
申请号：EP18807574.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , FERRARA, Steven, James , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MACCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3458459A1
公开(公告)日：2019-03-27
申请号：EP17734982.6
申请日：2017-05-17
发明人： JOHANNES, Sarah Anna Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , CHRIST, Clara , FERNANDEZ-MONTALVAN, Amaury, Ernesto , MÖWES, Manfred , LIENAU, Philipp , EIS, Knut , SACK, Ulrike , MÖNNING, Ursula , SCHOLZ, Arne , KUHNKE, Joachim , THEDE, Kai , WERBECK, Nicolas , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61K31/4162 , A61P35/00
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公开(公告)号：EP3710456A1
公开(公告)日：2020-09-23
申请号：EP18810918.5
申请日：2018-11-15
发明人： FURST, Laura , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin
IPC分类号： C07D513/22 , A61P35/00 , A61K31/5377
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公开(公告)号：EP3710450A1
公开(公告)日：2020-09-23
申请号：EP18811160.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , MORTIER, Jeremie, Xavier , MCCARREN, Patrick, Ryan , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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7.发明公开
公开(公告)号：EP3710449A1
公开(公告)日：2020-09-23
申请号：EP18810917.7
申请日：2018-11-15
发明人： FERRARA, Steven, James , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula
IPC分类号： C07D487/14 , C07D403/04 , C07D498/14 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710451A1
公开(公告)日：2020-09-23
申请号：EP18811161.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , WITTROCK, Sven , MCKINNEY, David , SERRANO-WU, Michael, H. , LEMKE, Chris , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3601253A1
公开(公告)日：2020-02-05
申请号：EP18712899.6
申请日：2018-03-22
发明人： LÜCKING, Ulrich , HOG, Daniel , CHRIST, Clara , SACK, Ulrike , SIEGEL, Franziska , LIENAU, Philip , WERBECK, Nicolas
IPC分类号： C07D401/12 , C07D239/30 , C07D498/04 , A61K31/519 , A61P9/00 , A61P35/00
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公开(公告)号：EP3601236A1
公开(公告)日：2020-02-05
申请号：EP18712892.1
申请日：2018-03-22
发明人： LÜCKING, Ulrich , HOG, Daniel , CHRIST, Clara , SACK, Ulrike , SIEGEL, Franziska , LIENAU, Philip , WERBECK, Nicolas
IPC分类号： C07D239/30 , C07D498/08 , C07D498/18 , C07D213/61 , A61K31/519 , A61P35/00 , A61P9/00
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