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公开(公告)号：EP3710448A1
公开(公告)日：2020-09-23
申请号：EP18808247.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , LEMKE, Chris , SERRANO-WU, Michael, H. , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710451A1
公开(公告)日：2020-09-23
申请号：EP18811161.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , WITTROCK, Sven , MCKINNEY, David , SERRANO-WU, Michael, H. , LEMKE, Chris , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710456A1
公开(公告)日：2020-09-23
申请号：EP18810918.5
申请日：2018-11-15
发明人： FURST, Laura , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin
IPC分类号： C07D513/22 , A61P35/00 , A61K31/5377
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公开(公告)号：EP3710450A1
公开(公告)日：2020-09-23
申请号：EP18811160.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , MORTIER, Jeremie, Xavier , MCCARREN, Patrick, Ryan , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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5.发明公开
公开(公告)号：EP3710449A1
公开(公告)日：2020-09-23
申请号：EP18810917.7
申请日：2018-11-15
发明人： FERRARA, Steven, James , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula
IPC分类号： C07D487/14 , C07D403/04 , C07D498/14 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710447A1
公开(公告)日：2020-09-23
申请号：EP18807574.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , FERRARA, Steven, James , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MACCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3458459A1
公开(公告)日：2019-03-27
申请号：EP17734982.6
申请日：2017-05-17
发明人： JOHANNES, Sarah Anna Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , CHRIST, Clara , FERNANDEZ-MONTALVAN, Amaury, Ernesto , MÖWES, Manfred , LIENAU, Philipp , EIS, Knut , SACK, Ulrike , MÖNNING, Ursula , SCHOLZ, Arne , KUHNKE, Joachim , THEDE, Kai , WERBECK, Nicolas , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61K31/4162 , A61P35/00
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公开(公告)号：EP3194379A1
公开(公告)日：2017-07-26
申请号：EP15763619.2
申请日：2015-09-17
发明人： MENGEL, Anne , LERCHEN, Hans-Georg , MÖWES, Manfred , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , KUHNKE, Joachim , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNANDEZ-MONTALVAN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula , HOLTON, Simon
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I) as defined herein and their use as pharmaceuticals.
摘要翻译： 如本文所定义的式（I）化合物及其作为药物的用途。
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公开(公告)号：EP2958909A1
公开(公告)日：2015-12-30
申请号：EP14704594.2
申请日：2014-02-17
发明人： SIEGEL, Stephan , BÄURLE, Stefan , CLEVE, Arwed , HAENDLER, Bernard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , MÖNNING, Ursula , KRAUSE, Sabine , LEJEUNE, Pascale , BUSEMANN, Matthias , KUHNKE, Joachim
IPC分类号： C07D401/10 , C07D403/10 , C07D405/10 , A61K31/551 , A61P35/00 , A61P37/00 , A61P7/00 , A61P25/28 , A61P31/12 , C07D451/06 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/048
CPC分类号： A61K31/551 , C07D245/06 , C07D401/10 , C07D403/10 , C07D405/10 , C07D451/06 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/048 , C07D491/08 , C07D491/107 , C07D495/10 , C07D498/08 , C07D498/10
摘要： The invention relates to BET protein-inhibiting, in particular BRD4-inhibiting, bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), to the pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use thereof against hyper-proliferative diseases, in particular tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasia, atherosclerotic diseases, sepsis, autoimmune diseases, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, and male fertility control.
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公开(公告)号：EP2928884A1
公开(公告)日：2015-10-14
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
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