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公开(公告)号：EP3710448A1
公开(公告)日：2020-09-23
申请号：EP18808247.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , LEMKE, Chris , SERRANO-WU, Michael, H. , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710447A1
公开(公告)日：2020-09-23
申请号：EP18807574.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , FERRARA, Steven, James , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MACCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3458459A1
公开(公告)日：2019-03-27
申请号：EP17734982.6
申请日：2017-05-17
发明人： JOHANNES, Sarah Anna Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , CHRIST, Clara , FERNANDEZ-MONTALVAN, Amaury, Ernesto , MÖWES, Manfred , LIENAU, Philipp , EIS, Knut , SACK, Ulrike , MÖNNING, Ursula , SCHOLZ, Arne , KUHNKE, Joachim , THEDE, Kai , WERBECK, Nicolas , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61K31/4162 , A61P35/00
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公开(公告)号：EP3710451A1
公开(公告)日：2020-09-23
申请号：EP18811161.1
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , WITTROCK, Sven , MCKINNEY, David , SERRANO-WU, Michael, H. , LEMKE, Chris , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3710456A1
公开(公告)日：2020-09-23
申请号：EP18810918.5
申请日：2018-11-15
发明人： FURST, Laura , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin
IPC分类号： C07D513/22 , A61P35/00 , A61K31/5377
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公开(公告)号：EP3710450A1
公开(公告)日：2020-09-23
申请号：EP18811160.3
申请日：2018-11-15
发明人： THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , MORTIER, Jeremie, Xavier , MCCARREN, Patrick, Ryan , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号： C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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7.发明公开
公开(公告)号：EP3710449A1
公开(公告)日：2020-09-23
申请号：EP18810917.7
申请日：2018-11-15
发明人： FERRARA, Steven, James , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula
IPC分类号： C07D487/14 , C07D403/04 , C07D498/14 , A61P35/00 , A61K31/4162
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公开(公告)号：EP3959202A1
公开(公告)日：2022-03-02
申请号：EP20720796.0
申请日：2020-04-20
发明人： BOUCHE, Lea, Aurelie , KORR, Daniel , TER LAAK, Antonius , FERNANDEZ-MONTALVAN, Amaury, Ernesto , BARAK, Naomi , HILLIG, Roman , NEUHAUS, Roland , GORJANACZ, Matyas , PÜTTER, Vera , GRADL, Stefan, Nikolaus , HERBERT, Simon, Anthony , FERRARA, Steven, James , STRATHDEE, Craig , JAFFE, Jacob, D.
IPC分类号： C07D307/85 , C07D333/70 , C07D209/42 , C07D405/04 , C07D405/12 , C07D407/12 , C07D413/12 , C07D487/04 , A61K31/343 , A61P35/00
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公开(公告)号：EP3645531A1
公开(公告)日：2020-05-06
申请号：EP18731125.3
申请日：2018-06-21
发明人： BOUCHÉ, Léa, Aurélie , NGUYEN, Duy , KORR, Daniel , KOPPITZ, Marcus , TER LAAK, Antonius , FERNANDEZ-MONTALVAN, Amaury, Ernesto , NGUYEN, Thi, Thanh, Uyen , PRECHTL, Stefan , JANZER, Andreas
IPC分类号： C07D417/12 , C07D417/14 , C07D277/56 , A61P35/00 , A61K31/427
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公开(公告)号：EP2958923A1
公开(公告)日：2015-12-30
申请号：EP14705164.3
申请日：2014-02-18
发明人： SCHMEES, Norbert , BUCHMANN, Bernd , HAENDLER, Bernard , NEUHAUS, Roland , LEJEUNE, Pascale , KRÜGER, Martin , FERNANDEZ-MONTALVAN, Amaury, Ernesto , KÜNZER, Hermann , REHWINKEL, Hartmut
IPC分类号： C07D487/14 , A61K31/55 , A61P35/00 , A61P43/00
CPC分类号： C07D487/14 , A61K31/5517 , C07D519/00
摘要： BET-protein-inhibiting, in particular BRD2-, BRD3- and BRD4-inhibiting 4-substituted pyrrolo- and pyrazolo-diazepines, of general formula I in which X, Y, n, m, p, R
1 , R
2 , R
3 , R
4 and R
5 have the meanings indicated in the description, pharmaceutical agents containing the compounds according to the invention and the prophylactic and therapeutic use thereof for treating hyperproliferative diseases, in particular tumor diseases, are described. Furthermore, the use of the compounds according to the invention as BET-protein inhibitors in benign hyperplasias, in atherosclerotic diseases, in sepsis, in autoimmune diseases, in vascular diseases, in viral infections, in neurodegenerative diseases, in inflammatory diseases, in atherosclerotic diseases and for controlling fertility in males is described.
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