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公开(公告)号:EP3710447A1
公开(公告)日:2020-09-23
申请号:EP18807574.1
申请日:2018-11-15
发明人: THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , FERRARA, Steven, James , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MACCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , WILSON, Craig
IPC分类号: C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号:EP3458459A1
公开(公告)日:2019-03-27
申请号:EP17734982.6
申请日:2017-05-17
发明人: JOHANNES, Sarah Anna Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , CHRIST, Clara , FERNANDEZ-MONTALVAN, Amaury, Ernesto , MÖWES, Manfred , LIENAU, Philipp , EIS, Knut , SACK, Ulrike , MÖNNING, Ursula , SCHOLZ, Arne , KUHNKE, Joachim , THEDE, Kai , WERBECK, Nicolas , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan
IPC分类号: C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61K31/4162 , A61P35/00
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公开(公告)号:EP3710451A1
公开(公告)日:2020-09-23
申请号:EP18811161.1
申请日:2018-11-15
发明人: THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , WITTROCK, Sven , MCKINNEY, David , SERRANO-WU, Michael, H. , LEMKE, Chris , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann
IPC分类号: C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号:EP3710448A1
公开(公告)日:2020-09-23
申请号:EP18808247.3
申请日:2018-11-15
发明人: THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , LEMKE, Chris , SERRANO-WU, Michael, H. , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号: C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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公开(公告)号:EP3710456A1
公开(公告)日:2020-09-23
申请号:EP18810918.5
申请日:2018-11-15
发明人: FURST, Laura , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin
IPC分类号: C07D513/22 , A61P35/00 , A61K31/5377
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公开(公告)号:EP3710450A1
公开(公告)日:2020-09-23
申请号:EP18811160.3
申请日:2018-11-15
发明人: THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula , NOWAK-REPPEL, Katrin , MORTIER, Jeremie, Xavier , MCCARREN, Patrick, Ryan , SERRANO-WU, Michael, H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FERRARA, Steven, James , FURST, Laura , WEI, Guo , HARVEY, Rebecca, Ann , PAYNE, Daniel , PESNOT, Thomas , WILSON, Craig
IPC分类号: C07D487/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/20 , A61P35/00 , A61K31/4162
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7.
公开(公告)号:EP3710449A1
公开(公告)日:2020-09-23
申请号:EP18810917.7
申请日:2018-11-15
发明人: FERRARA, Steven, James , SERRANO-WU, Michael H. , LEMKE, Chris , MCKINNEY, David , FITZGERALD, Mark , NASVESCHUK, Christopher , LAZARSKI, Kiel , FURST, Laura , WEI, Guo , MCCARREN, Patrick, Ryan , THEDE, Kai , MENGEL, Anne , CHRIST, Clara , KUHNKE, Joachim , JOHANNES, Sarah, Anna, Liesa , BUCHGRABER, Philipp , KLAR, Ulrich , SACK, Ulrike , KAULFUSS, Stefan , FERNANDEZ-MONTALVAN, Amaury, Ernesto , WERBECK, Nicolas , MÖNNING, Ursula
IPC分类号: C07D487/14 , C07D403/04 , C07D498/14 , A61P35/00 , A61K31/4162
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8.SUBSTITUIERTE PYRAZOLO[1,5-A]PYRIDIN-3-CARBOXAMIDE UND IHRE VERWENDUNG 有权
标题翻译: SUBSTITUIERTE吡唑[1,5-A]吡啶-3-甲酰胺和IHRE VERWENDUNG公开(公告)号:EP3030562B1
公开(公告)日:2017-07-26
申请号:EP14749778.8
申请日:2014-08-05
发明人: VAKALOPOULOS, Alexandros , FOLLMANN, Markus , BUCHGRABER, Philipp , GROMOV, Alexey , HARTUNG, Ingo , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , MARQUARDT, Tobias , REDLICH, Gorden , DIETZ, Lisa , LI, Volkhart Min-Jian
IPC分类号: C07D471/04 , A61K31/437
CPC分类号: C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D519/00
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公开(公告)号:EP3083593A1
公开(公告)日:2016-10-26
申请号:EP14812505.7
申请日:2014-12-16
发明人: BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号: C07D401/14 , C07D413/14 , C07D491/107 , C07D495/10 , A61K31/4725
CPC分类号: C07D401/14 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D491/107 , C07D495/10
摘要: The present invention relates to novel substituted piperidinyl-tetrahydroquinolines, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for the promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular diseases of the heart, peripheral and cardiac vascular diseases, thromboembolic diseases and ischaemia, peripheral circulatory disorders, Raynaud's phenomenon, CREST syndrome, micro-circulation disorders, intermittent claudication, and peripheral and autonomic neuropathies.
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10.SUBSTITUIERTE IMIDAZO[1,2-A]PYRAZINCARBOXAMIDE UND IHRE VERWENDUNG 审中-公开
标题翻译: 取代的咪唑并[1,2-A] PYRAZINCARBOXAMIDE及其用途公开(公告)号:EP3030564A1
公开(公告)日:2016-06-15
申请号:EP14748200.4
申请日:2014-08-05
发明人: VAKALOPOULOS, Alexandros , FOLLMANN, Markus , HARTUNG, Ingo , BUCHGRABER, Philipp , JAUTELAT, Rolf , LINDNER, Niels , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , DIETZ, Lisa , LI, Volkhart Min-Jian
IPC分类号: C07D487/04 , A61K31/4985 , A61P9/00 , A61P11/00
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D519/00
摘要: The invention relates to novel, substituted imidazo[1,2-a]pyrazine-carboxamides, to a method for producing them, their use alone or in combinations for treating and/or preventing diseases and to their use for producing medicaments for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
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