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1.发明公开SUBSTITUIERTE 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- UND 7-SULFONYLMETHYL-INDOLE UND IHRE VERWENDUNG 审中-公开取代的7- SULFANYLMETHYL-，7- SULFINYLMETHYL-和7-磺酰甲基吲哚和它们的用途
公开(公告)号：EP2300423A1
公开(公告)日：2011-03-30
申请号：EP09768921.0
申请日：2009-06-16
发明人： KOLKHOF, Peter , BRÜNS, Astrid , THEDE, Kai , SCHLEMMER, Karl-Heinz , HILLISCH, Alexander , LANG, Dieter , GERISCH, Michael , GÖLLER, Andreas , GROSSER, Rolf , SCHMECK, Carsten , WOLTERING, Elisabeth , PRIEN, Olaf , PAULSEN, Holger , KERN, Armin
IPC分类号： C07D209/10 , C07D209/12 , C07D209/18 , C07D405/06 , C07D409/06 , A61K31/404 , A61P9/00
CPC分类号： C07D209/10 , C07D209/12 , C07D209/18 , C07D405/06 , C07D409/06
摘要： The present application relates to novel 7-sulfanylmethyl, 7-sulfinylmethyl and 7-sulfonylmethyl indole derivates, to a method for the production thereof, to the individual use or the use in combination for the treatment and/or prevention of diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases, particularly for the treatment and/or prevention of cardiovascular diseases.
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2.发明公开CYANOQUINOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE, AND MEDICAMENTS COMPRISING THEM 审中-公开CYANOCHINOLINDERIVATE，生产，使用和药物它们含有
公开(公告)号：EP2035433A1
公开(公告)日：2009-03-18
申请号：EP07764743.6
申请日：2007-06-15
发明人： PRIEN, Olaf , EIS, Knut , SCHWEDE, Wolfgang , GUENTHER, Judith , ZOPF, Dieter
IPC分类号： C07D495/04 , A61P35/00 , A61K31/435
CPC分类号： C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A) : in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
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3.发明授权CDK INHIBITORISCHE PYRIMIDINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 有权CDK抑制嘧啶，生产与应用，药物
公开(公告)号：EP1392662B1
公开(公告)日：2009-01-07
申请号：EP02738100.3
申请日：2002-05-23
发明人： BRUMBY, Thomas , JAUTELAT, Rolf , PRIEN, Olaf , SCHÄFER, Martina , SIEMEISTER, Gerhard , LÜCKING, Ulrich , HUWE, Christoph
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P35/00 , C07D239/47 , C07D239/34 , C07D239/42 , C07D405/12 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/65127
摘要： The invention relates to the pyrimidine derivatives of general formula (1), wherein R1, R2, X, A and B are defined as in the description, for use as inhibitors of the cyclin-dependent kinase. The invention further relates to the production thereof as well as to their use as medicament in the treatment of various diseases.
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4.发明公开
公开(公告)号：EP2049539A1
公开(公告)日：2009-04-22
申请号：EP07726170.9
申请日：2007-06-20
发明人： INCE, Stuart , PRIEN, Olaf , LU, Shoufu , YU, Hongyi , HUSEMANN, Manfred , SCHUCK, Karina
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to pyrazolopyrimidines according to the general formula (I) : and salts thereof, to pharmaceutical compositions comprising said pyrazolopyrimidines and to a method of preparing said pyrazolopyrimidines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment or prophylaxis of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth
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5.发明公开QUINAZOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS TYROSINE KINASE INHIBITORS AND MEDICAMENTS COMPRISING THEM 审中-公开喹唑啉衍生物，生产，它们的使用药物和酪氨酸激酶抑制剂，含
公开(公告)号：EP2041143A1
公开(公告)日：2009-04-01
申请号：EP07764744.4
申请日：2007-06-15
发明人： PRIEN, Olaf , EIS, Knut , SCHWEDE, Wolfgang , GUENTHER, Judith , ZOPF, Dieter , BRITTAIN, Dominic, E., A.
IPC分类号： C07D495/04 , A61K31/517 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
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6.发明公开
公开(公告)号：EP2035434A1
公开(公告)日：2009-03-18
申请号：EP07764746.9
申请日：2007-06-15
发明人： PRIEN, Olaf , EIS, Knut , NGUYEN, Duy , HUWE, Christoph , SCHWEDE, Wolfgang , GUENTHER, Judith , ZOPF, Dieter
IPC分类号： C07D495/04 , A61P35/00 , A61K31/435
CPC分类号： C07D513/04 , C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A) : in which R1, R2, W, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
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7.发明公开METASUBSTITUIERTE THIAZOLIDINONE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 审中-公开间位取代的噻唑烷酮，生产和使用AS DRUGS
公开(公告)号：EP1824834A1
公开(公告)日：2007-08-29
申请号：EP05813723.3
申请日：2005-12-12
发明人： SCHULZE, Volker, Klaus , EIS, Knut , WORTMANN, Lars , KOSEMUND, Dirk , PRIEN, Olaf , SIEMEISTER, Gerhard , HESS-STUMPP, Holger , EBERSPÄCHER, Uwe , ISLAM, Imadul
IPC分类号： C07D277/20 , C07D417/12 , A61K31/427 , A61K31/426
CPC分类号： C07D277/14 , C07D277/20 , C07D417/12 , C07D417/14
摘要： The invention relates to thiazolidinones of general formula (I), to the production thereof and to their use as inhibitors of the polo-like kinase (Plk) for treating different diseases.
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8.发明公开SUBSTITUIERTE IMIDAZO[1,2B]PYRIDAZINE ALS KINASE-INHIBITOREN, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 审中-公开取代的咪唑[1.2B]哒嗪激酶抑制剂，生产与应用，药物
公开(公告)号：EP2176266A2
公开(公告)日：2010-04-21
申请号：EP06775928.2
申请日：2006-09-01
发明人： PRIEN, Olaf , BADER, Benjamin , ZÜGEL, Ulrich , INCE, Stuart James , HUWE, Christoph , SCHUCK, Karina , EIS, Knut , LÜCKING, Ulrich , JAUTELAT, Rolf , GÜNTHER, Judith , HUSEMANN, Manfred
IPC分类号： C07D487/04 , A61K31/425 , A61P29/00
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors for kinases, methods for producing such inhibitors, intermediate products for producing the same, and uses thereof.
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9.发明公开NOVEL SULPHOXIMINE-SUBSTITUTED QUINAZOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS 审中-公开新SULPHOXIMIN - 取代喹唑啉和喹唑啉衍生物作为激酶抑制剂
公开(公告)号：EP2152672A1
公开(公告)日：2010-02-17
申请号：EP08749502.4
申请日：2008-05-23
发明人： EIS, Knut , PRIEN, Olaf , LUECKING, Ulrich , GUENTHER, Judith , ZOPF, Dieter , BROHM, Dirk , VÖHRINGER, Verena , WOLTERING, Elisabeth , BECK, Hartmut , LOBELL, Mario , LI, Volkhart, Min-Jian , GRESCHAT, Susanne
IPC分类号： C07D215/233 , C07D215/42 , C07D215/44 , C07D239/94 , C07D401/12 , A61K31/4706 , A61K31/4709 , A61K31/47 , A61P35/00 , A61P25/28
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
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10.发明公开OXO-SUBSTITUIERTE IMIDAZO[1,2b]PYRIDAZINE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 审中-公开OXO-SUBSTITUIERTE IMIDAZO [1,2b]吡咯烷酮，DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL
公开(公告)号：EP2044071A1
公开(公告)日：2009-04-08
申请号：EP07726169.1
申请日：2007-06-20
发明人： PRIEN, Olaf , EIS, Knut , BADER, Benjamin , GUENTHER, Judith , BONIN VON, Arne
IPC分类号： C07D487/04 , A61K31/5025 , A61P11/00 , A61P17/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
摘要： The invention relates to novel kinase inhibitors of general formula (I), wherein Q and R1 are defined as in the claims. The invention also relates to methods for producing said inhibitors, to intermediates for producing the same and to uses thereof.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂：其中Q和R 1在权利要求书中定义，制备这种抑制剂的方法，制备这种抑制剂的中间体和这种抑制剂的用途。
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