公开(公告)号：EP1742945B1

公开(公告)日：2009-12-30

申请号：EP05739438.9

申请日：2005-04-14

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  STASCH, Johannes-Peter ,  KAST, Raimund ,  MÜNTER, Klaus ,  GNOTH, Mark, Jean ,  FIGUEROA, PEREZ, Santiago ,  THUTEWOHL, Michael ,  BENNABI, Samir ,  LANG, Dieter ,  MITTENDORF, Joachim ,  RADTKE, Martin ,  EHMKE, Heimo c/o Universität Hamburg

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P9/10

CPC分类号： C07D471/04

摘要： The invention relates to substituted phenylamino-pyrimidines, to a method for their production and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular for the treatment of cardiovascular diseases.

公开(公告)号：EP2167499A2

公开(公告)日：2010-03-31

申请号：EP08773422.4

申请日：2008-06-13

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  SCHIROK, Hartmut ,  HÄRTER, Michael ,  SIEGEL, Stephan ,  RESTER, Ulrich ,  GERDES, Christoph ,  HEITMEIER, Stefan ,  VON DEGENFELD, Georges ,  BUCHMÜLLER, Anja ,  DITTRICH-WENGENROTH, Elke ,  SAATMANN, Uwe ,  STRASSBURGER, Julia ,  GNOTH, Mark, Jean ,  LANG, Dieter

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P7/02

CPC分类号： C07D413/14

摘要： The invention relates to novel, substituted oxazolidinones, methods for the production thereof, use thereof for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

公开(公告)号：EP2247579A1

公开(公告)日：2010-11-10

申请号：EP08773585.8

申请日：2008-06-13

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： NGUYEN, Duy ,  VON BONIN, Arne ,  HAERTER, Michael ,  SCHIROK, Hartmut ,  MENGEL, Anne ,  VON AHSEN, Oliver ,  SCHÄFER, Martina

IPC分类号： C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07C381/10 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D239/94 ,  C07C381/10 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I) processes for their preparation and their use as a medicament for the treatment of various diseases.

公开(公告)号：EP2212332A1

公开(公告)日：2010-08-04

申请号：EP08785784.3

申请日：2008-09-02

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  LI-SOMMER, Ying ,  BRANDS, Michael ,  LOBELL, Mario ,  TERSTEEGEN, Adrian ,  HIMMEL, Herbert ,  SCHLEMMER, Karl-Heinz ,  LANG, Dieter ,  PETERSEN, Kirstin ,  RENZ, Matthias ,  MUMBERG, Dominik ,  HOFFMANN, Jens ,  SIEMEISTER, Gerhard ,  BÖMER, Ulf

IPC分类号： C07D495/14 ,  C07D519/00 ,  C07D491/147 ,  A61K31/33 ,  A61P35/00

CPC分类号： C07D495/14 ,  C07D491/147 ,  C07D519/00

摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.

公开(公告)号：EP2097417A1

公开(公告)日：2009-09-09

申请号：EP07846581.2

申请日：2007-11-14

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  MITTENDORF, Joachim ,  STASCH, Johannes-Peter ,  WUNDER, Frank

IPC分类号： C07D487/04 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/58

CPC分类号： C07D487/04

摘要： The present application relates to novel aza-bicyclic compounds, processes for preparing them, their use either alone or in combinations for the treatment and/or prevention of diseases and their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

公开(公告)号：EP2066666A1

公开(公告)日：2009-06-10

申请号：EP07802075.7

申请日：2007-09-01

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： SCHIROK, Hartmut ,  MITTENDORF, Joachim ,  STASCH, Johannes-Peter ,  WUNDER, Frank ,  STOLL, Friederike ,  SCHLEMMER, Karl-Heinz

IPC分类号： C07D471/04 ,  C07D403/04 ,  C07D487/04 ,  A61K31/4745 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/4188 ,  A61K31/519 ,  A61K31/5025 ,  A61P9/04 ,  A61K9/10 ,  A61K9/12

CPC分类号： C07D471/04 ,  C07D403/04 ,  C07D487/04

摘要： The present application relates to compounds of the formula (I) which act as stimulators of soluble guanylate cyclase and to their use for treatment and/or prevention of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischaemias, vascular disorders, thromboembolic disorders and arteriosclerosis. L-CH2-M-Q (I) in which L is phenyl, pyridyl, furyl, thienyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl or (C5-C7)-cycloalkyl, M is a bicyclic heteroaryl group of the formula (a-1), (b-1) or (c-1), in which the attachment site to the group is -CH2-L, the attachment site to the group is Q, and A, B, D and E are each CH, CR1 or N, where not more than two of the ring members A, B, D and E are the same, and Q is an unsaturated or aromatic 5- or 6-membered heterocycle having up to four heteroatoms from the group of N, O and/or S.