公开(公告)号：EP1581848A2

公开(公告)日：2005-10-05

申请号：EP03756914.2

申请日：2003-07-14

申请人： BAYLOR COLLEGE OF MEDICINE ,  EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ,  Envivo Pharmaceuticals, Inc.

发明人： BOTAS, Juan ,  GONZALEZ, Cayetano ,  SERRANO, Luis ,  ZOGHBI, Huda, Y. ,  FALT, Edward ,  CUMMINGS, Christopher, J. ,  BOULIN, Christian

IPC分类号： G06F1/00

CPC分类号： G06T7/20 ,  G06T7/0012 ,  Y02A90/24 ,  Y02A90/26

摘要： A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.

公开(公告)号：EP1581848A3

公开(公告)日：2005-12-07

申请号：EP03756914.2

申请日：2003-07-14

申请人： BAYLOR COLLEGE OF MEDICINE ,  EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ,  Envivo Pharmaceuticals, Inc.

发明人： BOTAS, Juan ,  GONZALEZ, Cayetano ,  SERRANO, Luis ,  ZOGHBI, Huda, Y. ,  FALT, Edward ,  CUMMINGS, Christopher, J. ,  BOULIN, Christian

IPC分类号： G01N33/48

公开(公告)号：EP1495439A2

公开(公告)日：2005-01-12

申请号：EP03755883.0

申请日：2003-07-14

申请人： Baylor College of Medicine ,  EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ,  Envivo Pharmaceuticals, Inc.

发明人： BOTAS, Juan ,  GONZALEZ, Cayetano ,  SERRANO, Luis ,  ZOGHBI, Huda, Y. ,  FALT, Edward ,  CUMMINGS, Christopher, J. ,  BOULIN, Christian

IPC分类号： G06K9/00

CPC分类号： G06T7/20 ,  G06T7/0012 ,  Y02A90/24 ,  Y02A90/26

摘要： A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.

公开(公告)号：EP1511851A2

公开(公告)日：2005-03-09

申请号：EP03764651.0

申请日：2003-07-14

申请人： Baylor College of Medicine ,  EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ,  Envivo Pharmaceuticals, Inc.

发明人： BOTAS, Juan ,  GONZALES, Cayetano ,  SERRANO, Luis ,  ZOGHBI, Huda, Y. ,  FALT, Edward ,  CUMMINGS, Christopher, J. ,  BOULIN, Christian

IPC分类号： C12Q1/00

CPC分类号： G06T7/20 ,  G06T7/0012 ,  G06T2207/30004

摘要： The present invention provides a method for screening for the effect of a test on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.

公开(公告)号：EP1525466A2

公开(公告)日：2005-04-27

申请号：EP03736983.2

申请日：2003-06-11

申请人： Baylor College of Medicine ,  Envivo Pharmaceuticals, Inc.

发明人： ZOGHBI, Huda, Y. ,  WATASE, Kei ,  CUMMINGS, Christopher, J.

IPC分类号： G01N33/00 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0318 ,  C07K14/435 ,  C12N15/8509

摘要： The present invention utilizes a "knock-in" approach to provide a transgenic mammal containing integrated into its genome a repeating nucleotide sequence encoding a polyglutamine comprising at least about 154, preferably at least about 160, 200, 300, 400, 500, and up to 600 or more contiguous glutamine residues. The transgenic mammals normally display observable phenotypic changes. As such, they may serve as a model for disease processes in humans for such diseases as spinobulbar muscular atrophy (SBMA), Huntington's disease (HD), dentatorubral pallidoluysian atrophy (DRPLA), and the spinocerebellar ataxias types, 1,2,3,6,7, and 17. As a result of displaying pathology indicative of a human disease, the efficacy of an agent for treating human disease may be tested in the transgenic mammals.

公开(公告)号：EP1684574A1

公开(公告)日：2006-08-02

申请号：EP04795934.1

申请日：2004-10-21

申请人： Envivo Pharmaceuticals, Inc.

发明人： LOWE, David, A. ,  CUMMINGS, Christopher, J. ,  KEONIG, Gerhard

IPC分类号： A01K67/033 ,  G01N33/00

CPC分类号： A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C07K14/4711 ,  C07K14/8114 ,  C07K2319/02 ,  C12N15/8509 ,  C12N2830/008

摘要： The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human AβIowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

公开(公告)号：EP1827088A2

公开(公告)日：2007-09-05

申请号：EP05852683.1

申请日：2005-12-02

申请人： Envivo Pharmaceuticals, Inc.

发明人： SCHULTE, Joost ,  SHIH, Hsin-Pei ,  CUMMINGS, Christopher, J.

IPC分类号： A01K67/033 ,  A01K67/027

CPC分类号： A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/03 ,  C12N15/8509 ,  C12N2830/002

摘要： The present invention relates to populations of male and female non-human animals which can be induced to produce single sex populations, and which may comprise a heterologous gene of interest, preferably a neurodegenerative disease gene, which is expressed in a tissue specific manner. The invention also relates to methods for sorting a mixed population of non-human animal embryos and/or larvae into a single sex population.