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公开(公告)号：EP3600389A1
公开(公告)日：2020-02-05
申请号：EP18716138.5
申请日：2018-03-21
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
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2.发明授权TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEIN CLDN18.2 有权涉及自身蛋白CLDN18.2的体液免疫应答的肿瘤疫苗
公开(公告)号：EP2547695B1
公开(公告)日：2018-05-09
申请号：EP11707355.1
申请日：2011-03-09
申请人： Biontech Protein Therapeutics GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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公开(公告)号：EP4241786A3
公开(公告)日：2023-12-27
申请号：EP23172071.5
申请日：2018-03-21
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
摘要： The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
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公开(公告)号：EP4241786A2
公开(公告)日：2023-09-13
申请号：EP23172071.5
申请日：2018-03-21
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
摘要： The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
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公开(公告)号：EP3737386A1
公开(公告)日：2020-11-18
申请号：EP19701783.3
申请日：2019-01-10
申请人： BioNTech RNA Pharmaceuticals GmbH , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ERBAR, Stephanie , WALZER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , MORENO HERRERO, Jorge , KLAMP, Thorsten , KREITER, Sebastian , DIKEN, Mustafa , HELLER, Phillip
IPC分类号： A61K31/7105 , A61K39/12 , A61K9/00 , C12N15/87
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