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公开(公告)号：EP3737386A1
公开(公告)日：2020-11-18
申请号：EP19701783.3
申请日：2019-01-10
申请人： BioNTech RNA Pharmaceuticals GmbH , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ERBAR, Stephanie , WALZER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , MORENO HERRERO, Jorge , KLAMP, Thorsten , KREITER, Sebastian , DIKEN, Mustafa , HELLER, Phillip
IPC分类号： A61K31/7105 , A61K39/12 , A61K9/00 , C12N15/87
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公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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公开(公告)号：EP3901261A1
公开(公告)日：2021-10-27
申请号：EP21168950.0
申请日：2021-04-16
发明人： SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
摘要： This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
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公开(公告)号：EP3901260A1
公开(公告)日：2021-10-27
申请号：EP21168938.5
申请日：2021-04-16
发明人： SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
摘要： This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
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公开(公告)号：EP3484445A1
公开(公告)日：2019-05-22
申请号：EP17743293.7
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
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