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公开(公告)号：EP4368702A3
公开(公告)日：2024-08-14
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/005 , C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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公开(公告)号：EP4259161A1
公开(公告)日：2023-10-18
申请号：EP21839823.8
申请日：2021-12-07
申请人： BioNTech SE
IPC分类号： A61K31/7115 , C12N15/10 , C12N15/113 , C12P19/34 , C12Q1/6844
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公开(公告)号：EP4138897A1
公开(公告)日：2023-03-01
申请号：EP21720413.0
申请日：2021-04-16
申请人： BioNTech SE
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公开(公告)号：EP4139616A1
公开(公告)日：2023-03-01
申请号：EP21718593.3
申请日：2021-04-16
申请人： Pfizer Inc. , BioNTech SE
发明人： NAUTA, Marjoh , PEETERS, Dirk Jozef , VAN DOORSLAER, Tom Frank Steven , BADKAR, Advait Vijay , DARVARI, Ramin , WARNE, Nicholas William , JEAN, James , HENDRIKSE, Danny Pierre G. , SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
IPC分类号： F25D3/12 , A61K39/215 , A61K45/06 , B65D81/18 , C12N15/00
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公开(公告)号：EP4392140A1
公开(公告)日：2024-07-03
申请号：EP21769746.5
申请日：2021-09-01
申请人： BioNTech SE
发明人： RABE, Irena , BUFF, Maximilian , ZIEGENHALS, Thomas , DRÖGEMÜLLER, Johanna , KUHN, Andreas , FESSER, Stephanie , COMBS, Rodney Gene , ESCHMANN, Nicole , ROMINE, Jennifer Ann Schoborg , WILLIAMSON, Jenna Kathryn
IPC分类号： A61P31/14 , A61K31/7115 , C12N15/113 , C12P19/34
CPC分类号： C12P19/34 , A61P31/14 , C12N15/111 , C12N2330/3020130101
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公开(公告)号：EP4368702A2
公开(公告)日：2024-05-15
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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公开(公告)号：EP4139452A1
公开(公告)日：2023-03-01
申请号：EP21720748.9
申请日：2021-04-22
申请人： BioNTech SE
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