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公开(公告)号：EP4370552A1
公开(公告)日：2024-05-22
申请号：EP22754314.7
申请日：2022-07-13
申请人： BioNTech SE , Genmab A/S
发明人： SAHIN, Ugur , MUIK, Alexander , FELLERMEIER-KOPF, Sina , FU, Yali , ADAMS, Homer, III , BAJAJ, Gaurav , HIGGS, Brandon , FERESHTEH, Mark , SPIRES, Vanessa , BLUM, Jordan , GARRIDO CASTRO, Patricia , NIEWOOD, Michelle , GIESEKE, Friederike , BECKMANN, Karsten , PAULMANN, Claudia , KUZMANOV, Ivan , BREIJ, Esther Cornelia Wilhelmina , GUELEN, Lars , NEIJSSEN, Jost , DE KREUK, Bart-Jan , HIBBERT, Richard , SCHUURMAN, Janine , LABRIJN, Aran Frank
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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公开(公告)号：EP2943507B1
公开(公告)日：2020-02-26
申请号：EP14700200.0
申请日：2014-01-09
申请人： Genmab A/S
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3.发明公开
公开(公告)号：EP3153524A1
公开(公告)日：2017-04-12
申请号：EP16185985.5
申请日：2009-12-03
申请人： Genmab A/S
发明人： LABRIJN, Aran Frank , LOVERIX, Stefan , PARREN, Paul , VAN DE WINKEL, Jan , SCHUURMAN, Janine , LASTERS, Ignace
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , A61K51/10 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
摘要： The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
摘要翻译： 本发明涉及抗体的恒定区域，特别是IgG4的CH3区域中的位置，其影响CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。
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公开(公告)号：EP3091998A1
公开(公告)日：2016-11-16
申请号：EP15700081.1
申请日：2015-01-08
申请人： Genmab A/S
发明人： BRINK, Edward Norbert Van Den , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , ALTINTAS, Isil , PARREN, Paul , RADEMAKER, Rik
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/1063 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/4241 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/90 , C07K2317/92 , G01N33/6872 , G01N2333/7051
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP3693385A1
公开(公告)日：2020-08-12
申请号：EP19217231.0
申请日：2014-07-04
申请人： Genmab A/S
发明人： VAN DEN BRINK, Edward , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , PARREN, Paul
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP2943507A1
公开(公告)日：2015-11-18
申请号：EP14700200.0
申请日：2014-01-09
申请人： Genmab A/S
发明人： LABRIJN, Aran Frank , MEESTERS, Joyce , NEIJSSEN, Joost J. , VAN DEN BRINK, Edward Norbert , SCHUURMAN, Janine , PARREN, Paul
摘要： The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.
摘要翻译： 本发明涉及包含不同于人IgG1中存在的三个不同位置的氨基酸的二聚体蛋白质。 所述二聚蛋白中的六个能够在溶液中形成六聚体结构。
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公开(公告)号：EP2576621A1
公开(公告)日：2013-04-10
申请号：EP11722423.8
申请日：2011-05-27
申请人： Genmab A/S
发明人： GOEIJ, Bart de , HAIJ, Simone de , RIEDL, Thilo , HOET, René , BAADSGAARD, Ole , WINKEL, Jan van de , SATIJN, David , PARREN, Paul , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , BRINK, Edward N. van den
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：EP2389392A1
公开(公告)日：2011-11-30
申请号：EP10701360.9
申请日：2010-01-26
申请人： Genmab A/S
发明人： PARREN, Paul , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , SCHUURMAN, Janine , VINK, Tom , VAN DE WINKEL, Jan , LOVERIX, Stefan , LASTERS, Ignace
IPC分类号： C07K16/00 , C07K16/28 , C07K16/32 , A61K39/395 , A61P35/00
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626
摘要： The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
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9.发明公开TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 审中-公开MONO VALENTE人体产生抗体的转基因动物和这些动物可分离的抗体
公开(公告)号：EP2167669A2
公开(公告)日：2010-03-31
申请号：EP08748826.8
申请日：2008-05-30
申请人： Genmab A/S
发明人： SCHUURMAN, Janine , VINK, Tom , VAN DE WINKEL, Jan , LABRIJN, Aran Frank , PARREN, Paul , BLEEKER, Willem Karel , BEURSKENS, Frank , VAN BERKEL, Patrick
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译： 本发明涉及一种新颖的非人类转基因动物，其在抗原刺激能产生单价抗体结合选定的抗原，修饰的重链转基因方法用于产生非人转基因动物，用于免疫非人类转基因方法 动物以及单价抗体可获得的寻求免疫方法。
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公开(公告)号：EP3738979A1
公开(公告)日：2020-11-18
申请号：EP20159405.8
申请日：2014-01-09
申请人： Genmab A/S
发明人： LABRIJN, Aran Frank , MEESTERS, Joyce , NEIJSSEN, Joost J. , VAN DEN BRINK, Edward Norbert , SCHUURMAN, Janine , PARREN, Paul
摘要： Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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