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1.发明公开
公开(公告)号：EP2459562A1
公开(公告)日：2012-06-06
申请号：EP10739455.3
申请日：2010-07-30
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides compounds of formula l: ( I ) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula I.
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公开(公告)号：EP1814561A2
公开(公告)日：2007-08-08
申请号：EP05820258.1
申请日：2005-10-28
发明人： BABU, Yarlagadda S. , CHAND, Pooran , WU, Minwan , KOTIAN, Pravin L. , KUMAR, V., Satish , LIN, Tsu-hsing , EL-KATTAN, Yahya , GHOSH, Ajit, K. , HARRIS, Robert J.
IPC分类号： A61K31/7076
CPC分类号： C07D495/04 , A61K31/675 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07D491/048 , C07D493/04 , C07F9/6561 , C07H7/06 , C07H19/22 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
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3.发明公开
公开(公告)号：EP3939658A1
公开(公告)日：2022-01-19
申请号：EP21183553.3
申请日：2019-04-05
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda S. , ZHANG, Weihe , LU, Peng-Cheng , WU, Minwan , LV, Wei , NGUYEN, Trung Xuan , DANG, Zhao , CHINTAREDDY, Venkat R. , KUMAR, V. Satish , RAMAN, Krishnan
IPC分类号： A61P9/00 , A61P13/12 , A61P25/28 , A61P37/00 , C07D209/08 , C07D231/56 , C07D235/08 , C07D239/70 , C07D261/20 , C07D307/79 , C07D333/54 , C07D403/10 , C07D405/12 , C07D407/04 , C07D407/10 , C07D409/12 , C07D471/04 , C07D487/04 , C07D307/81
摘要： Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
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公开(公告)号：EP3828173A1
公开(公告)日：2021-06-02
申请号：EP20191747.3
申请日：2015-03-09
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda S. , WU, Minwan , CHINTAREDDY, Venkat R , KUMAR, Satish V , ZHANG, Weihe
IPC分类号： C07D231/14 , A61K31/415
摘要： Disclosed are compounds of formula (I), as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention and the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.
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公开(公告)号：EP1863500A2
公开(公告)日：2007-12-12
申请号：EP06739630.9
申请日：2006-03-23
发明人： BABU, Yarlagadda S. , CHAND, Pooran , WU, Minwan , KOTIAN, Pravin L. , KUMAR, V. Satish , LIN, Tsu-Hsing , EL-KATTAN, Yahya , GHOSH, Ajit K.
IPC分类号： A61K31/7064 , A61P31/12
CPC分类号： A61K31/7064 , A61K31/7056 , A61K31/7068 , A61K38/212 , A61K38/2292 , A61K45/06 , C07H7/06 , C07H11/04 , C07H19/22 , Y02A50/393 , Y02A50/465
摘要： The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections
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公开(公告)号：EP3113772B8
公开(公告)日：2020-11-25
申请号：EP15759254.4
申请日：2015-03-09
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda S. , WU, Minwan , CHINTAREDDY, Venkat R. , KUMAR, V. Satish , ZHANG, Weihe
IPC分类号： C07D403/12 , C07D401/14 , C07D231/14 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/12 , A61P7/02 , A61K31/415
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公开(公告)号：EP3638229A1
公开(公告)日：2020-04-22
申请号：EP18816547.6
申请日：2018-06-14
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda,S. , KUMAR, V. Satish , ZHANG, Weihe , LU, Peng-Cheng , RAMAN, Krishnan
IPC分类号： A61K31/417 , A61K31/4184 , A61K31/517 , C07D233/54 , C07D239/12 , C07D239/14
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公开(公告)号：EP2470537A2
公开(公告)日：2012-07-04
申请号：EP10748213.5
申请日：2010-08-27
IPC分类号： C07D487/04 , A61K31/4985 , A61P17/06 , A61P35/00 , A61P37/06
CPC分类号： C07D487/04
摘要： The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula (I).
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公开(公告)号：EP2114980B1
公开(公告)日：2012-06-27
申请号：EP08727625.9
申请日：2008-01-11
IPC分类号： C07H19/23 , A61K31/706 , A61P31/12 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
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公开(公告)号：EP4323344A1
公开(公告)日：2024-02-21
申请号：EP22788930.0
申请日：2022-04-14
发明人： KOTIAN, Pravin L. , BABU, Yarlagadda S. , ZHANG, Weihe , LU, Peng-Cheng , DANG, Zhao , RAMAN, Krishnan
IPC分类号： C07D231/14 , C07D401/04 , C07D401/12
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