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    ANTIMICROBIAL COMPOUNDS
    1.
    发明授权
    ANTIMICROBIAL COMPOUNDS 有权
    抗微生物化合物

    公开(公告)号：EP1404665B1

    公开(公告)日：2012-08-08

    申请号：EP02734905.9

    申请日：2002-06-14

    申请人： Biodiem Ltd.

    发明人： DENISENKO, Peter Prokofievich ,  SAPRONOV, Nikolay Sergeevich ,  TARASENKO, Alexander Alexandrovich

    IPC分类号： A61K31/36 ,  A61K31/4184 ,  C07D235/08 ,  C07D317/52 ,  C07D263/56 ,  A61P31/04 ,  A61P33/02 ,  A61P15/02 ,  A61P31/10 ,  C07D235/06

    CPC分类号： A61K31/357 ,  A61K31/36 ,  A61K31/4184 ,  C07D235/06 ,  C07D235/08 ,  C07D263/56 ,  C07D317/46 ,  C07D317/52 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/479 ,  Y02A50/481

    摘要： The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R 1 to R 5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R 6 and R 7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R 6 and R 7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

    摘要翻译： 本发明涉及一种治疗和/或预防微生物感染的方法，包括给予有效量的式（I）化合物的步骤，其中X和Y相同或不同并且选自 杂原子; 是取决于杂原子X和Y的双键或单键; R1至R5是相同或不同的并且选自氢或无害取代基; 并且R6和R7相同或不同并且选自氢和无害的取代基，或者R6和R7中的一个在存在双键时不存在，药学上可接受的盐或衍生物，前药，互变异构体和/或 其异构体。 本发明还涉及保护受试者免受辐射损伤的方法，癌症放射疗法的方法以及用作上述式（I）化合物的抗微生物剂或辐射保护剂的用途。 一些式（I）化合物是新的并且在本发明中也与包含它们的药物或兽药组合物一起描述。