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公开(公告)号：EP3897836A1
公开(公告)日：2021-10-27
申请号：EP20807535.8
申请日：2020-11-06
申请人： Biogaia AB
发明人： GRASSET, Estelle , KHAN, Muhammad , MÖLLSTAM, Bo , ROOS, Stefan
IPC分类号： A61P25/00 , A23L33/135 , A61K35/747 , C12N1/20 , C12R1/225 , C12R1/25
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公开(公告)号：EP3463385A1
公开(公告)日：2019-04-10
申请号：EP17728468.4
申请日：2017-05-26
发明人： ROOS, Stefan , LIU, Yuying , HE, Baokun , RHOADS, Jon Marc
IPC分类号： A61K31/708 , A61K35/747 , A61P37/00
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公开(公告)号：EP4086359A1
公开(公告)日：2022-11-09
申请号：EP22165915.4
申请日：2019-07-24
申请人： Biogaia AB
发明人： ROOS, Stefan , MÖLLSTAM, Bo
IPC分类号： C12R1/225
摘要： The present invention relates to lactic acid bacterial strains which are capable of producing or inducing the production of melatonin, for use in the production of melatonin in a subject. Preferred strains for such uses are capable of producing or inducing the production of adenosine. Therapeutic uses of such strains include the treatment or prevention of diseases associated with melatonin deficiency, for example infantile colic. Novel strains are also provided.
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公开(公告)号：EP4410298A2
公开(公告)日：2024-08-07
申请号：EP24182877.1
申请日：2020-04-17
申请人： Biogaia AB
发明人： ROOS, Stefan , KUNZE, Wolfgang , BIENENSTOCK, John
IPC分类号： A61K35/747
CPC分类号： A61K35/745 , A61K35/747 , A61P1/00 , C12N1/20 , C12R2001/0120210501 , C12N1/205
摘要： A method to provide therapeutic microvesicles from probiotic bacteria comprises exposing the bacteria to an inducing treatment during culturing to induce production and release of therapeutic microvesicles by the bacteria. The therapeutic microvesicles may be used in treatment of, for instance, colic, an infant or childhood gastrointestinal disorder or disease, a gastrointestinal pain disorder, a bone loss disease and/or a periodontal disease.
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公开(公告)号：EP4253571A3
公开(公告)日：2023-12-13
申请号：EP23186579.1
申请日：2020-11-06
申请人： Biogaia AB
发明人： GRASSET, Estelle , KHAN, Muhammad , MÖLLSTAM, Bo , ROOS, Stefan
IPC分类号： A61P25/00 , A23L33/135 , A61K35/747 , C12N1/20 , C12R1/225 , C12R1/25
摘要： The invention relates to selection of bacterial strain for use in treating a disease related to serotonin deficiency by culturing bacteria of a lactic acid producing bacterial strain, under aerobic conditions, in a culture medium comprising tryptophan. Any serotonin produced by the bacteria of the lactic acid producing bacterial strain in the culture medium is detected and the lactic acid producing bacterial strain is selected as effective in treating serotonin deficiency and/or a disease related to serotonin deficiency in a subject if serotonin is detected in the culture medium.
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公开(公告)号：EP4152963A1
公开(公告)日：2023-03-29
申请号：EP22712094.6
申请日：2022-03-11
申请人： Biogaia AB
发明人： ROOS, Stefan , HORCAJADA, Marie Noëlle , BONNET, Nicolas , SABATIER, Magalie , BOURQUI, Bertrand , PRIOULT, Guénolée Eliane Marie , DE BRUYN, Florac
IPC分类号： A23L33/135 , A23L33/125
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公开(公告)号：EP4152962A1
公开(公告)日：2023-03-29
申请号：EP22710204.3
申请日：2022-03-11
申请人： Biogaia AB
发明人： ROOS, Stefan , HORCAJADA, Marie Noëlle , BONNET, Nicolas , SABATIER, Magalie , BOURQUI, Bertrand , PRIOULT, Guénolée Eliane Marie , DE BRUYN, Florac
IPC分类号： A23L33/135 , C12N1/20 , A23L33/125
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8.发明授权CONTROLLED ACTIVATION OF THE REUTERIN-PRODUCTION MACHINERY OF LACTOBACILLUS REUTERI 有权罗伊氏乳杆菌的罗伊氏机械生产受控启动
公开(公告)号：EP2303295B1
公开(公告)日：2015-09-30
申请号：EP09762760.8
申请日：2009-06-10
申请人： Biogaia AB
发明人： ROOS, Stefan
摘要： Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterin in the bacterial cell during preservation and storage. In particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterin, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
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公开(公告)号：EP4056053A1
公开(公告)日：2022-09-14
申请号：EP21162451.5
申请日：2021-03-12
申请人： Biogaia AB
发明人： ROOS, Stefan , HORCAJADA, Marie Noëlle , BONNET, Nicolas , SABATIER, Magalie , BOURQUI, Bertrand , PRIOULT, Guénolée Eliane Marie , DE BRUYN, Florac
IPC分类号： A23L33/135 , C12N1/20
摘要： The present invention relates to probiotic Lactobacillus reuteri strain obtained by a step of growing the bacteria in a medium comprising galacto-oligosaccharides (GOS), so called pre-conditioning. The pre-conditioning method provides boosting effects of the probiotic L. reuteri strain, such as improved mineral absorption, in the gastrointestinal tract. The invention comprises methods for manufacturing and cultivating probiotic Lactobacillus reuteri strains, and products and first and second medical uses containing such strains.
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公开(公告)号：EP4056052A1
公开(公告)日：2022-09-14
申请号：EP21162450.7
申请日：2021-03-12
申请人： Biogaia AB
发明人： ROOS, Stefan , HORCAJADA, Marie Noëlle , BONNET, Nicolas , SABATIER, Magalie , BOURQUI, Bertrand , PRIOULT, Guénolée Eliane Marie , DE BRUYN, Florac
IPC分类号： A23L33/135 , A23L33/125
摘要： The invention herein relates generally to enhancing the survival and activity of probiotic Lactobacillus reuteri strains in mammals by pre-conditioning L. reuteri with GOS during cultivation and to a surprisingly high synbiotic effect of such a pre-conditioned probiotic L. reuteri strain when administered together with GOS further added in the composition. The invention therefore comprises methods for cultivating and manufacturing probiotic L. reuteri strains, and preparing products containing such pre-conditioned strains in combination with additional amounts of GOS. In more detail the present invention relates to a composition comprising a probiotic L. reuteri strain, obtained by a step of growing the bacteria in a medium comprising GOS ("pre-conditioning"), and administering the pre-conditioned bacteria together with further GOS in the final product. The inventors have found that such method induces surprisingly high and unexpected synbiotic beneficial effects of the probiotic bacteria in the gastrointestinal tract. The composition also induces an increased calcium and iron solubility.
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