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1.发明授权BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY 有权用于治疗肿瘤，神经学和免疫学中的人类疾病的双芳基化合物
公开(公告)号：EP3080103B1
公开(公告)日：2018-04-18
申请号：EP14825001.2
申请日：2014-12-11
发明人： HOPKINS, Brian, T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00
CPC分类号： C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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2.发明授权
公开(公告)号：EP3080103B9
公开(公告)日：2018-09-19
申请号：EP14825001.2
申请日：2014-12-11
发明人： HOPKINS, Brian, T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00
CPC分类号： C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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3.发明公开
公开(公告)号：EP3357921A2
公开(公告)日：2018-08-08
申请号：EP18160575.9
申请日：2014-12-11
发明人： HOPKINS, Brian T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00 , C07D239/30 , C07F5/02
CPC分类号： C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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4.发明公开
公开(公告)号：EP3357921A3
公开(公告)日：2018-09-12
申请号：EP18160575.9
申请日：2014-12-11
发明人： HOPKINS, Brian T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00 , C07D239/30 , C07F5/02
CPC分类号： C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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5.发明公开BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY 有权用于治疗肿瘤，神经学和免疫学中的人类疾病的双芳基化合物
公开(公告)号：EP3080103A1
公开(公告)日：2016-10-19
申请号：EP14825001.2
申请日：2014-12-11
发明人： HOPKINS, Brian, T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00
CPC分类号： C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
摘要翻译： 本发明提供了可用作布鲁顿酪氨酸激酶抑制剂并表现出其所需特性的化合物及其组合物。
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公开(公告)号：EP2970302A1
公开(公告)日：2016-01-20
申请号：EP14721638.6
申请日：2014-03-14
申请人： Biogen MA Inc.
发明人： PENG, Hairuo , XIN, Zhili , ZHANG, Lei , SUN, Lihong , KUMARAVEL, Gnanasambandam , TAVERAS, Art , WANG, Deping
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/551 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： A61K31/198 , A61K36/9068 , C07D487/04 , C07D519/00
摘要： Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX). Formula (1)
摘要翻译： 式（I）化合物及其药学上可接受的盐可调节一种或多种SIP受体的活性和/或autotaxin（ATX）的活性。 公式1）
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7.发明授权1-[7-(cis-4-methyl-cyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid derivatives as autotaxin (ATX) modulators for treating inflammations and autoimmune disorders 有权用于治疗炎症和自身免疫性疾病的1- [7-（顺-4-甲基 - 环己基氧基）-8-三氟甲基 - 萘-2-基甲基] - 哌啶-4-羧酸衍生物作为autotaxin（ATX）调节剂
公开(公告)号：EP2877166B1
公开(公告)日：2018-02-28
申请号：EP13822655.0
申请日：2013-07-26
申请人： Biogen MA Inc.
发明人： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , PENG, Hairuo , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , WANG, Deping , XIN, Zhili , ZHANG, Lei
IPC分类号： C07D217/22 , C07D221/22 , C07D223/06 , C07D471/08 , C07D209/52 , C07D211/34 , C07D295/096 , C07D211/62 , C07C255/59 , C07C229/46 , C07C229/48 , A61K31/015 , A61K31/4375 , A61K31/44 , A61K31/136 , A61K31/196 , A61P19/02 , A61P37/00 , A61P9/10 , A61P11/00
CPC分类号： C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
摘要： Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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公开(公告)号：EP2922821B1
公开(公告)日：2019-07-31
申请号：EP13805643.7
申请日：2013-11-20
申请人： Biogen MA Inc.
发明人： PENG, Hairuo , XIN, Zhili , SUN, Lihong , CHAN, Timothy , KUMARAVEL, Gnanasambandam , TAVERAS, Arthur, G.
IPC分类号： A61K45/06 , A61K31/196 , A61K31/197 , A61K31/40 , A61K31/445 , A61K31/4545 , A61K31/50 , C07D215/14 , C07D401/10 , C07D417/04 , C07D207/16 , C07D211/62 , C07D401/04 , C07D237/14 , C07D417/06 , C07D239/34 , C07D249/06 , C07D487/04 , C07C229/14 , C07C229/48
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公开(公告)号：EP2877185B1
公开(公告)日：2018-05-23
申请号：EP13823863.9
申请日：2013-07-26
申请人： Biogen MA Inc.
发明人： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , WANG, Deping , XIN, Zhili , ZHANG, Lei
IPC分类号： C07D213/79 , C07C47/575 , A61K31/683 , A61P19/02
CPC分类号： A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
摘要： Compounds of formula (I) can modulate the activity of autotaxin (ATX).
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公开(公告)号：EP2877180B1
公开(公告)日：2018-01-03
申请号：EP13822929.9
申请日：2013-07-26
申请人： Biogen MA Inc.
发明人： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , PENG, Hairuo , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , XIN, Zhili , ZHANG, Lei
IPC分类号： A61K31/435 , C07C229/00 , C07D215/20 , C07D401/04 , C07D213/74 , C07D217/22 , A61K31/439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61P19/02 , A61P29/00 , A61P37/06 , A61P17/06 , C07D239/42 , C07D205/04 , C07D491/10 , C07D451/00 , C07D451/14
CPC分类号： C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
摘要： Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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