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公开(公告)号：EP3049065A1
公开(公告)日：2016-08-03
申请号：EP13773604.7
申请日：2013-09-26
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Universitätsmedizin der Johannes Gutenberg-Universität Mainz
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , HÜSEMANN, Yves , DIKEN, Mustafa , REUTER, Kerstin , HEFESHA, Hossam
IPC分类号： A61K9/127 , A61K48/00 , A61K9/50 , A61K31/663
CPC分类号： A61K39/39 , A61K9/1271 , A61K9/1277 , A61K9/5073 , A61K31/675 , A61K39/0011 , A61K2039/55505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/572 , C12N15/88 , C12N2810/10
摘要： The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present invention relates to a pharmaceutical composition comprising RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes. Said pharmaceutical composition is useful for inducing an immune response. It is also useful in a prophylactic and/or therapeutic treatment of a disease involving an antigen. Furthermore, the present invention relates to a method for producing the RNA decorated particles such as RNA decorated lipid particles, preferably RNA decorated liposomes.
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公开(公告)号：EP2917350A1
公开(公告)日：2015-09-16
申请号：EP13792854.5
申请日：2013-11-07
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Universitätsmedizin der Johannes Gutenberg-Universität Mainz
发明人： SAHIN, Ugur , BEISSERT, Tim , POLEGANOV, Marco , HERZ, Stephanie , KOSTE, Lars
CPC分类号： C12N5/0696 , C12N2501/24 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/65 , C12N2501/727 , C12N2506/1307 , C12N2510/00
摘要： The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.
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公开(公告)号：EP2618835A1
公开(公告)日：2013-07-31
申请号：EP11761508.8
申请日：2011-09-19
申请人： Biontech AG , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及提供抗原特异性淋巴样细胞的有效方法。 这些淋巴样细胞可用于提供具有确定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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公开(公告)号：EP3099706A1
公开(公告)日：2016-12-07
申请号：EP14701918.6
申请日：2014-01-29
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , JPT Peptide Technologies GmbH
发明人： SAHIN, Ugur , DANESCHDAR, Matin , SCHMOLDT, Hans-Ulrich , PLUM, Laura-Marie , FIEDLER, Markus , REIMER, Ulf , SCHNATBAUM, Karsten
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K39/0005 , G01N33/5308 , G01N33/57492 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.
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公开(公告)号：EP2830593A1
公开(公告)日：2015-02-04
申请号：EP13713356.7
申请日：2013-03-25
申请人： BioNTech AG , TRON Translationale Onkologie an der Johannes Gutenberg-Universität Mainz Gemeinnützige GmbH , Universitätsmedizin der Johannes Gutenberg-Universität Mainz
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena, Mareen , REUTER, Kerstin
CPC分类号： A61K39/0011 , A61K9/1272 , A61K48/0025 , A61K2039/53 , A61K2039/55555
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：EP3027203A1
公开(公告)日：2016-06-08
申请号：EP14747589.1
申请日：2014-07-30
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , VORMBROCK, Kirsten , BENDER, Christian , SIMON, Petra , HARTMANN, Christoph , HUBICH, Stefanie , BUKUR, Thomas , LITZENBERGER, Thorsten
IPC分类号： A61K39/00 , A61K31/7105 , C07K14/47 , C12Q1/68 , G01N33/574
摘要： The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for cancer treatment involving a specific set of tumor antigens.
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公开(公告)号：EP2920209A1
公开(公告)日：2015-09-23
申请号：EP13789492.9
申请日：2013-11-12
申请人： BioNTech AG , Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , STADLER, Christiane , HOLLAND, Julia , BÄHR-MAHMUD, Hayat , BEISSERT, Tim , PLUM, Laura , LE GALL, Fabrice , JENDRETZKI, Arne , FIEDLER, Markus
IPC分类号： C07K16/28
摘要： The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor- associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.
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公开(公告)号：EP2240572B1
公开(公告)日：2015-02-11
申请号：EP08861423.5
申请日：2008-12-12
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , POLEGANOV, Marco , BEISSERT, Tim
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2510/00
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9.发明公开
公开(公告)号：EP3060679A1
公开(公告)日：2016-08-31
申请号：EP14789270.7
申请日：2014-10-24
申请人： BioNTech AG , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , SCHÄFER, Michael , FARYNA, Marta Magdalena , OMOKOKO, Tana , HEBICH, Lisa , SIMON, Petra , REICHARDT, Annett , YILDIZ, Özlem
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/158
摘要： The present invention relates to a kit and a method for determining whether a subject shows an immune response against an antigen.
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10.发明公开TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEINS 有权TUMORIMFPUNG麻醉师EINER HUMORALEN免疫GEGEN SELBSTPROTEINE
公开(公告)号：EP2547695A1
公开(公告)日：2013-01-23
申请号：EP11707355.1
申请日：2011-03-09
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者中针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。
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