公开(公告)号：EP2023874A2

公开(公告)日：2009-02-18

申请号：EP07809331.7

申请日：2007-06-04

申请人： Bioseek, Inc.

发明人： KUNKEL, Eric J. ,  HYTOPOULOS, Evangelos ,  PLAVEC, Ivan

IPC分类号： A61F13/00

CPC分类号： C12Q1/02 ,  A61K31/13 ,  A61K31/135 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/565 ,  A61K45/06 ,  A61L31/16 ,  G01N33/5061 ,  G01N33/5064 ,  G01N2800/323

摘要： Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.

摘要翻译： 抑制或预防再狭窄的药剂通过在一系列测定中测试测试药剂来鉴定，以测量测试药剂对细胞增殖，血栓形成，组织建模和炎症的作用。 使用本发明的组合物提供再狭窄治疗。

公开(公告)号：EP1269187A1

公开(公告)日：2003-01-02

申请号：EP01914718.0

申请日：2001-03-06

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  BUTCHER, Eugene, C. ,  MELROSE, Jennifer ,  PLAVEC, Ivan

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/505 ,  C12Q1/06 ,  G01N5/00 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5061 ,  G01N33/5064 ,  G01N33/5091 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N33/6872 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2500/10 ,  G01N2510/00

摘要： A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

公开(公告)号：EP1620722A2

公开(公告)日：2006-02-01

申请号：EP04750485.7

申请日：2004-04-23

申请人： Bioseek, Inc.

发明人： PLAVEC, Ivan ,  BERG, Ellen, L.

IPC分类号： G01N33/48 ,  G01N33/53

CPC分类号： G06F19/24 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5064 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20

摘要： The genes in a signaling pathway can be identified by over or under-expressing each member of a set of genes to be grouped in signaling pathways and measuring parameters under stimulatory conditions. Genes in a common signaling pathway give similar parameter profiles under such conditions. Moreover, the interactions between signaling pathways and the genes and gene products that mediate those interactions can be determined by measuring the response of those pathways to stimuli under conditions that reflect a complex cellular environment. The order in which genes and their products transmit signals through signaling pathways can be determined by assaying the effects of activators and inhibitors on those genes and gene products, and the mechanism of action of a compound of interest can be determined by comparing parameter profiles generated by the compound of interest to those generated with compounds of known mechanism of action.