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公开(公告)号：EP2818543B8
公开(公告)日：2018-03-07
申请号：EP12869142.5
申请日：2012-11-29
发明人： GUO, Xueping , SHI, Yanli , QIAO, Liping , FENG, Ning , WANG, Guanfeng , LI, Haina , XUE, Wei , WANG, Haiying , LUAN,Yihong , LIU, Aihua
IPC分类号： C12N1/20 , C12N9/26 , C12N15/56 , C12P19/28 , C07K14/32 , A61K8/73 , A61K31/728 , A61P17/02 , A61P9/00 , A61Q17/00 , C12R1/07
CPC分类号： C12N9/2474 , A23L33/17 , A23V2002/00 , A61K8/66 , A61K8/735 , A61K31/728 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , C08B37/0072 , C12N9/2408 , C12P19/26 , C12P19/28 , C12R1/07 , Y02P20/52
摘要： The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.
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2.发明公开BACILLUS, HYALURONIC ACID ENZYME, AND USES THEREOF 有权BACILLUS，HYALURONSÄUREENZYMUND VERWENDUNGEN DAVON
公开(公告)号：EP2818543A1
公开(公告)日：2014-12-31
申请号：EP12869142.5
申请日：2012-11-29
发明人： GUO, Xueping , SHI, Yanli , QIAO, Liping , FENG, Ning , WANG, Guanfeng , LI, Haina , XUE, Wei , WANG, Haiying , LUAN,Yihong , LIU, Aihua
IPC分类号： C12N1/20 , C12N9/26 , C12N15/56 , C12P19/28 , C07K14/32 , A61K8/73 , A61K31/728 , A61P17/02 , A61P9/00 , A61Q17/00 , C12R1/07
CPC分类号： C12N9/2474 , A23L33/17 , A23V2002/00 , A61K8/66 , A61K8/735 , A61K31/728 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , C08B37/0072 , C12N9/2408 , C12P19/26 , C12P19/28 , C12R1/07 , Y02P20/52
摘要： The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.
摘要翻译： 本发明提供芽孢杆菌属 存款号码为CGMCC NO。 5744和透明质酸酶产生的透明质酸酶和透明质酸酶的氨基酸序列示于SEQ ID NO：2中。本发明还涉及制备低聚透明质酸或其盐或低分子量透明质酸或 其通过使用由此产生的芽孢杆菌或透明质酸酶。 产生的低聚物透明质酸盐或低分子透明质酸酯具有良好的透皮吸收能力，高纯度，无细胞毒性，有效的抗氧化能力等优点。 本发明还提供了具有存取通道号CGMCC NO的芽孢杆菌的用途。 5744，或透明质酸酶，低聚物透明质酸盐或其盐，低分子量透明质酸盐或其盐，其由化妆品，食品和药物领域中的芽孢杆菌产生。
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公开(公告)号：EP2818543B1
公开(公告)日：2018-01-10
申请号：EP12869142.5
申请日：2012-11-29
发明人： GUO, Xueping , SHI, Yanli , QIAO, Liping , FENG, Ning , WANG, Guanfeng , LI, Haina , XUE, Wei , WANG, Haiying , LUAN,Yihong , LIU, Aihua
IPC分类号： C12N1/20 , C12N9/26 , C12N15/56 , C12P19/28 , C07K14/32 , A61K8/73 , A61K31/728 , A61P17/02 , A61P9/00 , A61Q17/00 , C12R1/07
CPC分类号： C12N9/2474 , A23L33/17 , A23V2002/00 , A61K8/66 , A61K8/735 , A61K31/728 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , C08B37/0072 , C12N9/2408 , C12P19/26 , C12P19/28 , C12R1/07 , Y02P20/52
摘要： The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.
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