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公开(公告)号：EP3512837A1
公开(公告)日：2019-07-24
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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公开(公告)号：EP2215065A1
公开(公告)日：2010-08-11
申请号：EP08839335.0
申请日：2008-10-14
发明人： DEY, Kaka , GAO, Donghong Amy , GOLDBERG, Daniel R. , HEIM-RIETHER, Alexander , MANGETTE, John E. , MUGGE, Ingo Andreas , SNOW, Roger , SWINAMER, Alan David , WU, Jiang-ping , XIONG, Zhaoming , YANG, Yu
IPC分类号： C07D239/26 , C07D249/06 , C07D257/04 , C07C217/62
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I) or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其互变异构体或其药学上可接受的盐，其中R 1至R 11，W，X，Y，Z和n如本文所定义。 本发明还涉及使用式（I）化合物及其组合物治疗患者各种疾病和病症的方法。 本发明还涉及制备式（I）化合物的方法和在这些方法中有用的中间体。
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公开(公告)号：EP3512837B1
公开(公告)日：2020-07-22
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
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公开(公告)号：EP2215065B1
公开(公告)日：2012-07-11
申请号：EP08839335.0
申请日：2008-10-14
发明人： DEY, Kaka , GAO, Donghong Amy , GOLDBERG, Daniel R. , HEIM-RIETHER, Alexander , MANGETTE, John E. , MUGGE, Ingo Andreas , SNOW, Roger , SWINAMER, Alan David , WU, Jiang-ping , XIONG, Zhaoming , YANG, Yu
IPC分类号： C07D239/26 , C07D249/06 , C07D257/04 , C07C217/62
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I) or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
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