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公开(公告)号：EP4441055A1
公开(公告)日：2024-10-09
申请号：EP22823522.2
申请日：2022-11-30
发明人： BROEKER, Joachim , ABBOTT, Jason , CUI, Jianwen , FESIK, Stephen W. , FUCHS, Julian , GOLLNER, Andreas , HERDEIS, Lorenz , HODGES, Tim , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , RAMHARTER, Juergen , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SOKOL, Kevin , STADTMUELLER, Heinz , SUN, Qi , TREU, Matthias , WATERSON, Alex , WILDING, Birgit , WUNBERG, Tobias
IPC分类号： C07D498/10 , A61K31/513 , A61K31/519 , A61K31/551 , A61K31/553 , A61P35/00
CPC分类号： C07D498/10 , A61K45/06 , A61P35/00
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公开(公告)号：EP4441050A1
公开(公告)日：2024-10-09
申请号：EP22826076.6
申请日：2022-11-30
发明人： BROEKER, Joachim , ABBOTT, Jason , CUI, Jianwen , FESIK, Stephen W. , GOLLNER, Andreas , HODGES, Tim , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , WATERSON, Alex
IPC分类号： C07D413/14 , C07D417/14 , A61P35/00 , A61K31/506 , A61K31/4245
CPC分类号： C07D413/14 , C07D417/14 , A61P35/00
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公开(公告)号：EP4441056A1
公开(公告)日：2024-10-09
申请号：EP22826084.0
申请日：2022-11-30
发明人： BROEKER, Joachim , ABBOTT, Jason , CUI, Jianwen , FESIK, Stephen W. , FUCHS, Julian , HERDEIS, Lorenz , HODGES, Tim , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , RAMHARTER, Juergen , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , TREU, Matthias , WATERSON, Alex , WILDING, Birgit , WUNBERG, Tobias
IPC分类号： C07D498/10 , A61P35/00 , A61K31/423
CPC分类号： C07D498/10 , A61P35/00
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公开(公告)号：EP4441054A1
公开(公告)日：2024-10-09
申请号：EP22823521.4
申请日：2022-11-30
发明人： BROEKER, Joachim , ABBOTT, Jason , CUI, Jianwen , FESIK, Stephen W. , FUCHS, Julian , GOLLNER, Andreas , HERDEIS, Lorenz , HODGES, Tim , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , WATERSON, Alex
IPC分类号： C07D498/10 , C07D515/20 , A61K31/513 , A61K31/541 , A61K31/551 , A61P35/00
CPC分类号： C07D498/10 , C07D515/20 , A61K31/5513 , A61K31/506 , A61K45/06
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公开(公告)号：EP3512837B1
公开(公告)日：2020-07-22
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
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公开(公告)号：EP4441053A1
公开(公告)日：2024-10-09
申请号：EP22823514.9
申请日：2022-11-30
发明人： BROEKER, Joachim , ABBOTT, Jason , CUI, Jianwen , FESIK, Stephen W. , FUCHS, Julian , GOLLNER, Andreas , HERDEIS, Lorenz , HODGES, Tim , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , WATERSON, Alex , WUNBERG, Tobias
IPC分类号： C07D498/10 , A61K31/513 , A61P35/00
CPC分类号： C07D498/10
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公开(公告)号：EP4157837A1
公开(公告)日：2023-04-05
申请号：EP21729877.7
申请日：2021-06-01
发明人： ABBOTT, Jason , BROEKER, Joachim , CUI, Jianwen , FESIK, Stephen W. , GOLLNER, Andreas , HODGES, Tim , KAROLYI-OEZGUER, Jale , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , TREU, Matthias , WATERSON, Alex
IPC分类号： C07D413/14 , C07D417/14 , C07D409/14 , A61P35/00 , A61K31/381 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10
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公开(公告)号：EP4157836A1
公开(公告)日：2023-04-05
申请号：EP21729875.1
申请日：2021-06-01
发明人： ABBOTT, Jason , BROEKER, Joachim , CUI, Jianwen , FESIK, Stephen W. , GOLLNER, Andreas , HODGES, Tim , KAROLYI-OEZGUER, Jale , LITTLE, Andrew , MANTOULIDIS, Andreas , PHAN, Jason , SARKAR, Dhruba , SMETHURST, Christian Alan Paul , SUN, Qi , TREU, Matthias , WATERSON, Alex
IPC分类号： C07D413/14 , C07D417/14 , C07D409/14 , A61P35/00 , A61K31/381
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公开(公告)号：EP3512837A1
公开(公告)日：2019-07-24
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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