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公开(公告)号：EP3512837A1
公开(公告)日：2019-07-24
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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公开(公告)号：EP2655371A1
公开(公告)日：2013-10-30
申请号：EP11808470.6
申请日：2011-12-16
发明人： BETAGERI, Rajashekhar , COOK, Brian, Nicholas , DISALVO, Darren , HARCKEN, Christian , KUZMICH, Daniel , LIU, Pingrong , LORD, John , MAO, Can , RAZAVI, Hossein
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4162 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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公开(公告)号：EP2346868A1
公开(公告)日：2011-07-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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公开(公告)号：EP3512837B1
公开(公告)日：2020-07-22
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
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公开(公告)号：EP2346868B1
公开(公告)日：2016-01-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
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公开(公告)号：EP3512833A1
公开(公告)日：2019-07-24
申请号：EP17768914.8
申请日：2017-09-06
发明人： LIU, Pingrong , MILLER, Craig Andrew , YU, Maolin , ZHANG, Zhonghua , RUPPEL, Sabine , PADYANA, Anil K.
IPC分类号： C07D231/12 , C07D403/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61P37/00
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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公开(公告)号：EP2655371B1
公开(公告)日：2015-02-25
申请号：EP11808470.6
申请日：2011-12-16
发明人： BETAGERI, Rajashekhar , COOK, Brian, Nicholas , DISALVO, Darren , HARCKEN, Christian , KUZMICH, Daniel , LIU, Pingrong , LORD, John , MAO, Can , RAZAVI, Hossein
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4162 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
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8.发明授权GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472B1
公开(公告)日：2012-01-18
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
9.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472A1
公开(公告)日：2011-03-30
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
公开(公告)号：EP3512833B1
公开(公告)日：2020-07-29
申请号：EP17768914.8
申请日：2017-09-06
发明人： LIU, Pingrong , MILLER, Craig Andrew , YU, Maolin , ZHANG, Zhonghua , RUPPEL, Sabine , PADYANA, Anil K.
IPC分类号： C07D231/12 , C07D403/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61P37/00
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