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公开(公告)号：EP3512833A1
公开(公告)日：2019-07-24
申请号：EP17768914.8
申请日：2017-09-06
发明人： LIU, Pingrong , MILLER, Craig Andrew , YU, Maolin , ZHANG, Zhonghua , RUPPEL, Sabine , PADYANA, Anil K.
IPC分类号： C07D231/12 , C07D403/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61P37/00
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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2.发明授权DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权[ - - 1,2-a]咪唑-3-羧酸酰胺的6,7-二氢-5H-咪唑并衍生物
公开(公告)号：EP2225238B1
公开(公告)日：2014-09-03
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
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公开(公告)号：EP3512837B1
公开(公告)日：2020-07-22
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
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4.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权衍生物6,7-二氢-5H-咪唑并[1,2-A] - 咪唑烷-3-羧酸钠
公开(公告)号：EP2225238A1
公开(公告)日：2010-09-08
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
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公开(公告)号：EP3512833B1
公开(公告)日：2020-07-29
申请号：EP17768914.8
申请日：2017-09-06
发明人： LIU, Pingrong , MILLER, Craig Andrew , YU, Maolin , ZHANG, Zhonghua , RUPPEL, Sabine , PADYANA, Anil K.
IPC分类号： C07D231/12 , C07D403/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61P37/00
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公开(公告)号：EP3512837A1
公开(公告)日：2019-07-24
申请号：EP17768582.3
申请日：2017-09-06
发明人： CUI, Jianwen , GAO, Donghong Amy , LIU, Pingrong , MCKIBBEN, Bryan Patrick , MILLER, Craig Andrew , RAZAVI, Hossein , RUPPEL, Sabine , PADYANA, Anil K. , SPENCER, Elizabeth
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61P29/00 , A61P35/00 , A61P37/06
摘要： or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
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7.发明公开2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 审中-公开CCR10 2-磺酰基氨基-4-杂芳基butyloamide拮抗剂
公开(公告)号：EP2276731A1
公开(公告)日：2011-01-26
申请号：EP09730594.0
申请日：2009-04-08
发明人： ABEYWARDANE, Asitha , COGAN, Derek , CHOI, Younggi , GAO, Donghong A. , GOLDBERG, Daniel R. , HEIM-RIETHER, Alexander , MILLER, Craig Andrew , RAMSDEN, Philip Dean , SMITH KEENAN, Lana Louise , SNOW, Roger John , YU, Yang
IPC分类号： C07D207/34 , C07D211/16 , C07D403/12 , C07D513/04 , A61K31/439 , A61P25/28
CPC分类号： C07D211/16 , C07D207/34 , C07D403/12 , C07D513/04
摘要： This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R
1 , R
2 , R
4 . Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
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