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1.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES 有权6,7-二氢-5H-咪唑并[1,2-A]咪唑-3-羧酸酰胺衍生物
公开(公告)号：EP2445909A1
公开(公告)日：2012-05-02
申请号：EP10720512.2
申请日：2010-05-26
发明人： LEMIEUX, Rene, Marc , BRUNETTE, Steven, Richard , HORAN, Joshua, Courtney , KOWALSKI, Jennifer, A. , LAWLOR, Michael, David , MCKIBBEN, Bryan , MILLER, Craig, Andrew , BARBOSA, Antonio, J.M.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4439 , A61K31/501 , A61K31/4375 , A61K31/506 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-
a ]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.-
公开(公告)号：EP2991985A1
公开(公告)日：2016-03-09
申请号：EP14727313.0
申请日：2014-04-28
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，m和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗由醛固酮活性介导或维持的多种疾病的方法，所述疾病包括肾病，糖尿病性肾病，心血管疾病和纤维化病症，制备这些化合物的方法 化合物和中间体在这些过程中有用。
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3.发明授权DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES 有权衍生物6,7-二氢-5H-咪唑并[1,2-A]咪唑-3-基碳酸钠
公开(公告)号：EP2445909B1
公开(公告)日：2013-11-13
申请号：EP10720512.2
申请日：2010-05-26
发明人： LEMIEUX, Rene, Marc , BRUNETTE, Steven, Richard , HORAN, Joshua, Courtney , KOWALSKI, Jennifer, A. , LAWLOR, Michael, David , MCKIBBEN, Bryan , MILLER, Craig, Andrew , BARBOSA, Antonio, J.M.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4439 , A61K31/501 , A61K31/4375 , A61K31/506 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
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4.发明授权DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权[ - - 1,2-a]咪唑-3-羧酸酰胺的6,7-二氢-5H-咪唑并衍生物
公开(公告)号：EP2225238B1
公开(公告)日：2014-09-03
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
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公开(公告)号：EP2991985B1
公开(公告)日：2018-06-13
申请号：EP14727313.0
申请日：2014-04-28
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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6.发明公开DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES 有权衍生物6,7-二氢-5H-咪唑并[1,2-A] - 咪唑烷-3-羧酸钠
公开(公告)号：EP2225238A1
公开(公告)日：2010-09-08
申请号：EP08853791.5
申请日：2008-11-20
发明人： LEMIEUX, Rene M. , BARBOSA, Antonio Jose Del Moral , BENTZIEN, Joerg Martin , BRUNETTE, Steven Richard , CHEN, Zhidong , COGAN, Derek , GAO, Donghong A. , HEIM-RIETHER, Alexander , HORAN, Joshua Courtney , KOWALSKI, Jennifer A. , LAWLOR, Michael David , LIU, Weimin , MCKIBBEN, Bryan , MILLER, Craig Andrew , MOSS, Neil , TSCHANTZ, Matt Aaron , XIONG, Zhaoming , YU, Hui , YU, Yang
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
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7.发明公开SUBSTITUTED BENZYLIMIDAZOLES USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开取代benzylimidazoles炎症性疾病的治疗
公开(公告)号：EP1869012A1
公开(公告)日：2007-12-26
申请号：EP06740459.0
申请日：2006-04-04
IPC分类号： C07D401/12 , C07D401/14 , C07D233/54 , C07D233/88 , C07D233/70 , A61K31/415 , A61K31/454 , A61P29/00
CPC分类号： C07D233/64 , C07D233/70 , C07D233/88 , C07D401/12 , C07D401/14
摘要： The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.
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