-
公开(公告)号：EP2991985A1
公开(公告)日：2016-03-09
申请号：EP14727313.0
申请日：2014-04-28
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，m和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗由醛固酮活性介导或维持的多种疾病的方法，所述疾病包括肾病，糖尿病性肾病，心血管疾病和纤维化病症，制备这些化合物的方法 化合物和中间体在这些过程中有用。
-
公开(公告)号：EP3172212A1
公开(公告)日：2017-05-31
申请号：EP15744459.7
申请日：2015-07-23
发明人： BURKE, Jennifer , COGAN, Derek , LORD, John , MARSHALL, Daniel Richard , MCKIBBEN, Bryan P. , YU, Maolin , ZHANG, Yunlong , CERNY, Matthew A. , FADER, Lee , FREDERICK, Kosea S. , SURPRENANT, Simon
IPC分类号： C07D491/052 , A61K31/4188 , A61P13/12 , A61P9/10
CPC分类号： C07D491/052
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein Cy, R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，其中Cy，R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
-
公开(公告)号：EP2321274A1
公开(公告)日：2011-05-18
申请号：EP09789924.9
申请日：2009-06-24
发明人： BENTZIEN, Joerg, Martin , BOYER, Stephen, James , BURKE, Jennifer , ELDRUP, Anne, Bettina , GUO, Xin , HUBER, John, David , KIRRANE, Thomas, Martin , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David
IPC分类号： C07D207/09 , C07D211/34 , C07D211/82 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
-
公开(公告)号：EP2991985B1
公开(公告)日：2018-06-13
申请号：EP14727313.0
申请日：2014-04-28
发明人： BALESTRA, Michael , BURKE, Jennifer , CHEN, Zhidong , COGAN, Derek , FADER, Lee , GUO, Xin , MCKIBBEN, Bryan , MARSHALL, Daniel Richard , NEMOTO, Peter Allen , YU, Hui
IPC分类号： C07D471/04 , A61K31/444 , C07D498/04 , A61P9/00
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
公开(公告)号：EP3250569A1
公开(公告)日：2017-12-06
申请号：EP16704980.8
申请日：2016-01-28
发明人： BALESTRA, Michael , BENTZIEN, Jörg , BURKE, Jennifer , COGAN, Derek , GUO, Xin , HORNBERGER, Keith, R. , LORD, John , MEYERS, Kenneth, M. , YU, Maolin , ZHANG, Zhonghua , XIONG, Zhaoming
IPC分类号： C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D261/20 , C07D498/04 , A61K31/423 , A61P29/00
CPC分类号： C07D261/20 , A61P13/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D498/04
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
6.发明公开HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE 有权杂环相关的PYRROLOPYRIDIN-或苯并咪唑
公开(公告)号：EP2509979A1
公开(公告)日：2012-10-17
申请号：EP10788192.2
申请日：2010-12-01
发明人： BOYER, Stephen, James , BURKE, Jennifer , GUO, Xin , KIRRANE JR., Thomas, Martin , SNOW, Roger, John , ZHANG, Yunlong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.-
7.发明公开
公开(公告)号：EP3475262A1
公开(公告)日：2019-05-01
申请号：EP17734614.5
申请日：2017-06-21
发明人： MCKIBBEN, Bryan P. , MEYERS, Kenneth Michael , ZHANG, Yunlong , MARSHALL, Daniel Richard , COGAN, Derek , LORD, John , CHEN, Zhidong , BURKE, Jennifer , BALESTRA, Michael
IPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D405/04 , C07D471/04 , A61K31/4184 , A61P9/00 , A61P13/12
-
公开(公告)号：EP3250569B1
公开(公告)日：2019-01-09
申请号：EP16704980.8
申请日：2016-01-28
发明人： BALESTRA, Michael , BENTZIEN, Jörg , BURKE, Jennifer , COGAN, Derek , GUO, Xin , HORNBERGER, Keith, R. , LORD, John , MEYERS, Kenneth, M. , YU, Maolin , ZHANG, Zhonghua , XIONG, Zhaoming
IPC分类号： C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D261/20 , C07D498/04 , A61K31/423 , A61P29/00
-
公开(公告)号：EP3172212B1
公开(公告)日：2018-06-13
申请号：EP15744459.7
申请日：2015-07-23
发明人： BURKE, Jennifer , COGAN, Derek , LORD, John , MARSHALL, Daniel Richard , MCKIBBEN, Bryan P. , YU, Maolin , ZHANG, Yunlong , CERNY, Matthew A. , FADER, Lee , FREDERICK, Kosea S. , SURPRENANT, Simon
IPC分类号： C07D491/052 , A61K31/4188 , A61P13/12 , A61P9/10
CPC分类号： C07D491/052
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein Cy, R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
10.发明授权HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE 有权杂环相关的PYRROLOPYRIDIN-或苯并咪唑
公开(公告)号：EP2509979B1
公开(公告)日：2016-05-25
申请号：EP10788192.2
申请日：2010-12-01
发明人： BOYER, Stephen, James , BURKE, Jennifer , GUO, Xin , KIRRANE JR., Thomas, Martin , SNOW, Roger, John , ZHANG, Yunlong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.018 秒)
