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公开(公告)号：EP2350083A1
公开(公告)日：2011-08-03
申请号：EP09782789.3
申请日：2009-09-08
发明人： MANTOULIDIS, Andreas , DAHMANN, Georg , ETTMAYER, Peter , KLEIN, Christian , STEURER, Steffen , WAIZENEGGER, Irene , ZAHN, Stephan Karl
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R
1 to R
4 , X
1 , X
2 , X
3 , L
1 and L
2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof in such a treatment.-
2.发明授权
公开(公告)号：EP1154788B9
公开(公告)日：2007-09-12
申请号：EP00909162.0
申请日：2000-02-14
发明人： UHLMANN, Frank , NASMYTH, Kim , PETERS, Jan-Michael , WAIZENEGGER, Irene , BUONOMO, Sara , CLYNE, Rosemary
CPC分类号： G01N33/5011 , G01N2800/7023
摘要： Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent birth defects and to increase ploidy in plants.
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公开(公告)号：EP2350083B1
公开(公告)日：2017-05-17
申请号：EP09782789.3
申请日：2009-09-08
发明人： MANTOULIDIS, Andreas , DAHMANN, Georg , ETTMAYER, Peter , KLEIN, Christian , STEURER, Steffen , WAIZENEGGER, Irene , ZAHN, Stephan Karl
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2176249A2
公开(公告)日：2010-04-21
申请号：EP08774578.2
申请日：2008-07-01
发明人： SAPOUNTZIS, Ioannis , ETTMAYER, Peter , KLEIN, Christian , MANTOULIDIS, Andreas , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04 , A61K31/41 , A61K31/4427
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中基团R2至R4，L，Q和n如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，及其用于 制备具有上述性质的药物组合物。
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公开(公告)号：EP2041132A2
公开(公告)日：2009-04-01
申请号：EP07787138.2
申请日：2007-07-05
发明人： ENGELHARDT, Harald , BADER, Gerd , BOEHMELT, Guido , BRUECKNER, Ralph , GERSTBERGER, Thomas , IMPAGNATIELLO, Maria , KUHN, Daniel , SCHAAF, Otmar , STADTMUELLER, Heinz , WAIZENEGGER, Irene , ZOEPHEL, Andreas
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention encompasses compounds of general Formula (I) wherein X and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括其中X和R 1至R 3如权利要求1中所定义的通式（I）的化合物，其适用于治疗以过度或异常细胞增殖为特征的疾病，以及其用于制备药物组合物的用途，所述药物组合物具有 上述特性。
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公开(公告)号：EP2173734B1
公开(公告)日：2016-03-23
申请号：EP08774579.0
申请日：2008-07-01
发明人： SAPOUNTZIS, Ioannis , ETTMAYER, Peter , KLEIN, Christian , MANTOULIDIS, Andreas , STEURER, Steffen , WAIZENEGGER, Irene
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D417/14 , C07D487/08
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
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公开(公告)号：EP2663303A1
公开(公告)日：2013-11-20
申请号：EP12700082.6
申请日：2012-01-12
发明人： SOLCA, Flavio , GUERTLER, Ulrich , SANDERSON, Michael , TONTSCH-GRUNT, Ulrike , WAIZENEGGER, Irene
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/506 , A61K45/06 , A61P35/00
CPC分类号： A61K31/496 , A61K9/0019 , A61K9/08 , A61K9/2018 , A61K9/2059 , A61K31/404 , A61K31/4045 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The invention describes anti-cancer therapies comprising using dual Aurora kinase/MEK inhibitors as described herein.
摘要翻译： 本发明描述了包含使用如本文所述的双极光激酶/ MEK抑制剂的抗癌疗法。
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8.发明公开9H- PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES 有权2,6-DIAMINO-9H-PURIN-DERIVATE UND IHRE VERWENDUNGFÜRDIE BEHANDLUNG VON PROLIFAATIVEN ERKRANKUNGEN
公开(公告)号：EP2134723A1
公开(公告)日：2009-12-23
申请号：EP08717387.8
申请日：2008-03-04
发明人： STADTMUELLER, Heinz , BOEHMELT, Guido , ENGELHARDT, Harald , HIRT, Ulrich , SCHAAF, Otmar , WAIZENEGGER, Irene
IPC分类号： C07D519/00 , A61K31/52
CPC分类号： C07D519/00
摘要： The present invention encompasses compounds of general formula (1) wherein R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1，R 2和R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，及其用于制备具有 上述属性。
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公开(公告)号：EP1154788B1
公开(公告)日：2007-07-11
申请号：EP00909162.0
申请日：2000-02-14
发明人： UHLMANN, Frank , NASMYTH, Kim , PETERS, Jan-Michael , WAIZENEGGER, Irene , BUONOMO, Sara , CLYNE, Rosemary
CPC分类号： G01N33/5011 , G01N2800/7023
摘要： Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent birth defects and to increase ploidy in plants.
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公开(公告)号：EP4314036A1
公开(公告)日：2024-02-07
申请号：EP22717801.9
申请日：2022-03-24
发明人： ITTIG, Simon , KASPER, Christoph , SAUPE, Falk , AMSTUTZ, Marlise , DUVAL, Mélodie , WAIZENEGGER, Irene
IPC分类号： C07K14/705 , A61K35/74 , A61K38/17 , A61K38/51 , A61K39/395 , A61P35/00 , C07K14/715 , C07K16/28 , C12N9/12 , C12N9/14 , C12N9/88
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