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1.发明公开METHOD OF DETERMINING THE PROBABILITY OF A THERAPEUTIC RESPONSE IN CANCER CHEMOTHERAPY WITH CARDIAC GLYCOSIDE 有权确定用Herzglylycoside治疗癌症化疗的治疗反应概率的方法
公开(公告)号：EP2231165A4
公开(公告)日：2010-12-15
申请号：EP08850574
申请日：2008-11-06
IPC分类号： G01N33/574 , A61K31/58 , A61K31/704 , A61K36/24 , G01N33/564
CPC分类号： G01N33/573 , A61K31/513 , A61K31/58 , A61K31/7008 , A61K31/704 , A61K31/7048 , A61K36/24 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Y306/01003 , G01N33/574 , G01N33/6872 , G01N2333/914 , G01N2800/52 , G01N2800/7023 , G01N2800/7028 , G06F19/12
摘要： A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
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2.发明公开
公开(公告)号：EP1988825A2
公开(公告)日：2008-11-12
申请号：EP07763612.4
申请日：2007-02-08
发明人： YUN, Seok-Hyun
CPC分类号： C07K14/70503 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/4795 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
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公开(公告)号：EP3327441A1
公开(公告)日：2018-05-30
申请号：EP16830490.5
申请日：2016-07-25
IPC分类号： G01N33/68 , A61K31/519 , A61K35/14 , A61K35/28 , A61K41/00 , A61P7/00 , G01N33/53 , G01N33/543
CPC分类号： G01N33/6893 , A61K31/519 , A61K35/14 , A61K35/28 , A61K41/00 , G01N33/53 , G01N33/543 , G01N33/68 , G01N2333/46 , G01N2800/52 , G01N2800/7023
摘要： The present invention relates to a method for assisting the diagnosis of the condition of myelofibrosis (MF), a method for assisting the prognostic prediction of MF, and a method for monitoring the therapeutic effect on MF. The present invention also relates to an apparatus for executing these methods. Furthermore, the present invention relates to a marker for determining the condition of myelofibrosis.
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公开(公告)号：EP3083698A1
公开(公告)日：2016-10-26
申请号：EP14871151.8
申请日：2014-12-18
申请人： Arocell AB
发明人： ERIKSSON, Staffan
CPC分类号： C07K16/40 , C07K2317/34 , C12N9/1211 , C12Y207/01021 , G01N33/573 , G01N2333/9122 , G01N2800/26 , G01N2800/54 , G01N2800/7023
摘要： The embodiments relate to monoclonal antibodies or fragments capable of binding to a serum form of human TK1 and to kits and methods involving the use of such monoclonal antibodies or fragments.
摘要翻译： 实施方案涉及能够结合血清形式的人TK1的单克隆抗体或片段以及涉及使用这种单克隆抗体或片段的试剂盒和方法。
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公开(公告)号：EP2825626A1
公开(公告)日：2015-01-21
申请号：EP13713105.8
申请日：2013-03-14
申请人： Centre National de la Recherche Scientifique , Université de Strasbourg , INSERM (Institut National de la Santé et de la Recherche Médicale)
CPC分类号： G01N33/5005 , G01N33/5014 , G01N33/5023 , G01N33/5026 , G01N33/5091 , G01N2500/04 , G01N2500/10 , G01N2800/7023
摘要： The present invention relates to methods and devices for observing eukaryotic cells devoid of cell wall, in particular for observing the cytokinetic ring, the device comprising a plurality of wells suitable for containing only one single eukaryotic cell and characterized in that the dimensions of the wells constrain the cells into an oblong shape with a long axis parallel to the depth of the wells.
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6.发明公开
公开(公告)号：EP2231165A1
公开(公告)日：2010-09-29
申请号：EP08850574.8
申请日：2008-11-06
IPC分类号： A61K31/704 , A61K31/58 , G01N33/574
CPC分类号： G01N33/573 , A61K31/513 , A61K31/58 , A61K31/7008 , A61K31/704 , A61K31/7048 , A61K36/24 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Y306/01003 , G01N33/574 , G01N33/6872 , G01N2333/914 , G01N2800/52 , G01N2800/7023 , G01N2800/7028 , G06F19/12
摘要： A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
摘要翻译： 的治疗用人强心苷的方法，是游离缺失盘。 使用的预后测定法和试剂盒及其方法被提供。 所述试剂盒和测定法是用来确定矿具有在具有与过量细胞增殖相关病因学的疾病的强心苷对治疗的治疗响应病变细胞或组织的可能性。 所述试剂盒和测定法是用来确定从矿井患病细胞或组织获得的Na，K-ATP酶的α亚单位的同种型的比率。 该试剂盒可用于预测癌症或肿瘤的治疗反应在受试者中治疗与强心苷。 所述试剂盒和测定法可用于治疗的疾病或具有与用包含强心苷的组合物过度的细胞增殖相关病因学疾病的方法来引入。
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公开(公告)号：EP1154788A1
公开(公告)日：2001-11-21
申请号：EP00909162.0
申请日：2000-02-14
发明人： UHLMANN, Frank , NASMYTH, Kim , PETERS, Jan-Michael , WAIZENEGGER, Irene , BUONOMO, Sara , CLYNE, Rosemary
CPC分类号： G01N33/5011 , G01N2800/7023
摘要： Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent birth defects and to increase ploidy in plants.
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8.发明授权
公开(公告)号：EP2825626B1
公开(公告)日：2018-04-11
申请号：EP13713105.8
申请日：2013-03-14
申请人： Centre National de la Recherche Scientifique , Université de Strasbourg , INSERM (Institut National de la Santé et de la Recherche Médicale)
CPC分类号： G01N33/5005 , G01N33/5014 , G01N33/5023 , G01N33/5026 , G01N33/5091 , G01N2500/04 , G01N2500/10 , G01N2800/7023
摘要： The present invention relates to methods and devices for observing eukaryotic cells devoid of cell wall, in particular for observing the cytokinetic ring, the device comprising a plurality of wells suitable for containing only one single eukaryotic cell and characterized in that the dimensions of the wells constrain the cells into an oblong shape with a long axis parallel to the depth of the wells.
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9.发明公开METHODS, ARRANGEMENTS AND SYSTEMS FOR OBTAINING INFORMATION ASSOCIATED WITH AN ANATOMICAL SAMPLE USING OPTICAL MICROSCOPY 审中-公开方法，措施和与解剖样本相关信息获取利用光学显微镜系统
公开(公告)号：EP3143926A1
公开(公告)日：2017-03-22
申请号：EP16185740.4
申请日：2007-02-08
发明人： Yun, Seok-Hyun
CPC分类号： C07K14/70503 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/4795 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
摘要翻译： 提供了用于获取与在解剖样品相关联的信息的装置和方法。 对于实施例，至少一个第一电磁辐射可被提供给所述解剖样品，以便产生所述解剖样品中的至少一个声波。 至少一个第二电磁辐射可基于声波产生。 至少一个第二电磁辐射中的至少一个部分可以以与解剖样品中的至少一个部分相关联的确定性矿信息来提供。 此外，基于与所述第二电磁辐射相关联的数据中的信息进行分析。 所述第一电磁辐射可包括至少一个第一量值和至少一个第一频率。 第二电磁辐射可以包括至少一个第二级和至少一个第二频率。 该数据可以涉及在第一和第二幅度和/或所述第一和第二频率之间的第二差值之间的第一差值。 第二差可以是大约-100 GHz和100千兆赫，但不包括零之间。
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10.发明授权
公开(公告)号：EP1988825B1
公开(公告)日：2016-12-21
申请号：EP07763612.4
申请日：2007-02-08
发明人： YUN, Seok-Hyun
CPC分类号： C07K14/70503 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/4795 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
摘要翻译： 提供了用于获取与在解剖样品相关联的信息的装置和方法。 对于实施例，至少一个第一电磁辐射可被提供给所述解剖样品，以便产生所述解剖样品中的至少一个声波。 至少一个第二电磁辐射可基于声波产生。 至少一个第二电磁辐射中的至少一个部分可以以与解剖样品中的至少一个部分相关联的确定性矿信息来提供。 此外，基于与所述第二电磁辐射相关联的数据中的信息进行分析。 所述第一电磁辐射可包括至少一个第一量值和至少一个第一频率。 第二电磁辐射可以包括至少一个第二级和至少一个第二频率。 该数据可以涉及在第一和第二幅度和/或所述第一和第二频率之间的第二差值之间的第一差值。 第二差可以是大约-100 GHz和100千兆赫，但不包括零之间。
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