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公开(公告)号：EP3555063B1
公开(公告)日：2020-09-16
申请号：EP17811299.1
申请日：2017-12-07
发明人： STEURER, Steffen , DAHMANN, Georg , KERRES, Nina , KOEGL, Manfred
IPC分类号： C07D401/12 , C07D401/14 , A61K9/00 , A61K9/08 , A61K9/20 , A61K47/02 , A61K31/415 , A61P35/00
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2.发明公开
公开(公告)号：EP2655355A1
公开(公告)日：2013-10-30
申请号：EP11799717.1
申请日：2011-12-21
发明人： STEURER, Steffen
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4439 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R
2 to R
4 , A,X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.摘要翻译： 本发明包括通式（I）的化合物，其中基团R 2至R 4，A，X和m如权利要求1中所定义，其适用于治疗特征在于细胞增殖过度或异常的疾病，药物制剂 其中含有这种化合物及其作为药物的用途。
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公开(公告)号：EP2350083A1
公开(公告)日：2011-08-03
申请号：EP09782789.3
申请日：2009-09-08
发明人： MANTOULIDIS, Andreas , DAHMANN, Georg , ETTMAYER, Peter , KLEIN, Christian , STEURER, Steffen , WAIZENEGGER, Irene , ZAHN, Stephan Karl
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R
1 to R
4 , X
1 , X
2 , X
3 , L
1 and L
2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof in such a treatment.-
公开(公告)号：EP1828123A1
公开(公告)日：2007-09-05
申请号：EP05817469.9
申请日：2005-12-15
发明人： MCCONNELL, Darryl , WEYER-CZERNILOFSKY, Ulrike , IMPAGNATIELLO, Maria , STEURER, Steffen , BRUECKNER, Ralph , KRIST, Bernd , BETZEMEIER, Bodo , HILBERG, Frank , HECKEL, Armin , ROTH, Gerald Juergen , KLEY, Joerg , LEHMANN-LINTZ, Thorsten
IPC分类号： C07D209/34 , C07D405/06 , C07D403/12 , C07D413/04 , C07D401/10 , C07D405/10 , C07D403/04 , C07D401/14 , C07D409/04 , C07D401/04 , A61K31/4523 , A61P35/00
CPC分类号： C07D409/04 , C07D209/34 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/10 , C07D413/04
摘要： The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
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公开(公告)号：EP2552907A1
公开(公告)日：2013-02-06
申请号：EP11710782.1
申请日：2011-03-25
发明人： ETTMAYER, Peter , STEURER, Steffen
IPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , A61K31/496 , A61K31/444 , A61P35/00
CPC分类号： C07D401/14 , A61K31/496 , A61K31/551 , A61K45/06 , C07D405/14 , C07D409/14
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R
0 to R
3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.摘要翻译： 本发明包括通式（1）的化合物，其中基团R 0至R 3和L如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，含有此类化合物的药物制剂 和它们作为药物的用途。
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公开(公告)号：EP2007773B1
公开(公告)日：2012-10-24
申请号：EP07727564.2
申请日：2007-03-30
发明人： STEURER, Steffen , BETZEMEIER, Bodo , MCCONNELL, Darryl , GERSTBERGER, Thomas , GRAUERT, Matthias , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , VAN DER VEEN, Lars , WEYER-CZERNILOFSKY, Ulrike
IPC分类号： C07D513/04 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04
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公开(公告)号：EP2173734A2
公开(公告)日：2010-04-14
申请号：EP08774579.0
申请日：2008-07-01
发明人： SAPOUNTZIS, Ioannis , ETTMAYER, Peter , KLEIN, Christian , MANTOULIDIS, Andreas , STEURER, Steffen , WAIZENEGGER, Irene
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D417/14 , C07D487/08
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中基团R1至R3和L如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，及其用于制备药物 具有上述特性。
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8.发明公开PHENYL SUBSTITUIERTE HETEROARYL-DERIVATE UND DEREN VERWENDUNG ALS ANTITUMORMITTEL 审中-公开苯基取代杂芳基衍生物及其作为抗肿瘤药
公开(公告)号：EP2041116A1
公开(公告)日：2009-04-01
申请号：EP07787143.2
申请日：2007-07-05
发明人： STEURER, Steffen , ETTMAYER, Peter , MANTOULIDIS, Andreas , SAPOUNTZIS, Ioannis , STEEGMAIER, Martin
IPC分类号： C07D401/12 , C07D401/14 , C07D417/14 , C07D413/14 , C07D403/14 , C07D413/12 , A61K31/4439 , A61K31/41 , A61K31/40 , A61P29/00 , A61P35/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of general formula (I), wherein the radicals R2 to R4, L, Q and n are defined as indicated in claim 1. Said compounds are suitable for treating diseases that are characterised by excessive or anomal cell proliferation. The invention also relates to their use for producing a medicament having the above-mentioned properties.
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公开(公告)号：EP1799690B1
公开(公告)日：2008-04-16
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
摘要翻译： 本发明涉及通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病。 本发明还涉及所述化合物用于制备具有上述性质的药物的用途。
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公开(公告)号：EP1799690A1
公开(公告)日：2007-06-27
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
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