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公开(公告)号：EP2010513A2
公开(公告)日：2009-01-07
申请号：EP07727956.0
申请日：2007-04-11
发明人： RIES, Uwe , SPROLL, Sonja , WERTHMANN, Ulrike , ZOPF, Andreas , HUCHLER, Günther
IPC分类号： C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to the novel crystalline compounds A of general formula (I), wherein A1, A2, A3, X, Y1, Y2, and Y3 are defined as indicated in claim 1, and which are provided in the form of the physiologically acceptable salts thereof with acids, said acids being selected among group B comprising hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, benzenesulfonic acid, p-toluenesulfonic acid, maleic acid, succinic acid, fumaric acid, D-(-)-tartaric acid, L-(+)-tartaric acid, naphthalene-2-sulfonic acid, and naphthalene-1,5-disulfonic acid, as well as the polymorphs, the respective solvates and hydrates.
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公开(公告)号：EP3585392A1
公开(公告)日：2020-01-01
申请号：EP18708929.7
申请日：2018-02-21
发明人： SAND, Michael Steven , ROSENBROCK, Holger , GIOVANNINI, Riccardo , ADACHI, Masashi , BETZEMEIER, Bodo , BRODMANN, Tobias , KAMATA, Takayuki , KAWABATA, Yohei , ITO, Masanori , MARCKART, Daniel Jens , NAKATANI, Manabu , WERTHMANN, Ulrike
IPC分类号： A61K31/519 , C07D487/04 , A61P25/18
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3.发明授权SALT FORMS OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 有权的6 FLUOR -1,2-二氢-2-氧代-3H-吲哚-3- YLIDENDERIVATS，PROCESS FOR THEIR和药物组合物含的盐形式
公开(公告)号：EP2238108B1
公开(公告)日：2012-08-29
申请号：EP09703697.4
申请日：2009-01-22
IPC分类号： C07D209/34 , A61K31/404 , A61P35/00
CPC分类号： C07D209/34
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公开(公告)号：EP2625174A1
公开(公告)日：2013-08-14
申请号：EP11764572.1
申请日：2011-10-06
发明人： FRANK, Markus , HAEBERLE, Hans , HENRY, Manuel , PACHUR, Thorsten , SANTAGOSTINO, Marco , STERTZ, Uwe , TREBING, Thomas , WERTHMANN, Ulrike
IPC分类号： C07D401/14 , C07D211/58 , C07D213/81 , C07D401/04 , A61K31/454 , A61P31/00
CPC分类号： C07D401/14 , C07D211/58 , C07D213/81 , C07D401/04
摘要： This invention relates to co-crystals and salts of CCR3 inhibitors of formula (1), pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.
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5.发明公开SÄUREADDITIONSSALZE DES 2-[2-[[(4-METHOXY-2,6-DIMETHYLPHENYL)SULFONYL]-(METHYL)AMINO]ETHOXY]-N-METHYL-N-[3-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]ACETAMIDS UND IHRE VERWENDUNG ALS BRADYKININ-B1 REZEPTOR ANTAGONISTEN 审中-公开作者2-酸加成盐[ - [[（4-甲氧基-2,6-二甲基苯基）磺酰基] - 2-（甲基）氨基]乙氧基] -N-甲基-N- [3-（4-甲基哌嗪-1-基）环己基 ]乙酰胺和它们作为缓激肽B1受体拮抗剂的用途
公开(公告)号：EP2601181A1
公开(公告)日：2013-06-12
申请号：EP11741454.0
申请日：2011-08-04
发明人： PACHUR, Thorsten , PFRENGLE, Waldemar , BIRK, Manfred , SCHNAUBELT, Juergen , WERTHMANN, Ulrike
IPC分类号： C07D295/135 , A61K31/495 , A61P29/00
CPC分类号： C07D295/155 , C07D295/135
摘要： The invention relates to the novel acid addition salts AB of the following free base of formula (A) or the enantiomer thereof with a physiologically acceptable acid B selected from the group consisting of hydrochloric acid, fumaric acid, and tartaric acid and to the polymorphs, hydrates, and solvates thereof.
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6.发明授权NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 有权新哌啶DIHYDROTHIEN嘧啶亚砜及其用途用于治疗哮喘和COPD的治疗
公开(公告)号：EP2748156B1
公开(公告)日：2015-12-16
申请号：EP12762543.2
申请日：2012-08-17
发明人： POUZET, Pascale, A., J. , NICKOLAUS, Peter , WERTHMANN, Ulrike , FRUTOS, Rogelio, P. , YANG, Bing-Shiou , KIM, Soojin , MULDER, Jason, Alan , PATEL, Nitinchandra , SENANAYAKE, Chris, H. , TAMPONE, Thomas, G. , WEI, Xudong
IPC分类号： C07D401/04 , C07D495/04 , C07C211/35 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
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7.发明公开NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 有权新哌啶DIHYDROTHIEN嘧啶亚砜及其用途用于治疗哮喘和COPD的治疗
公开(公告)号：EP2748156A1
公开(公告)日：2014-07-02
申请号：EP12762543.2
申请日：2012-08-17
发明人： POUZET, Pascale, A., J. , NICKOLAUS, Peter , WERTHMANN, Ulrike , FRUTOS, Rogelio, P. , YANG, Bing-Shiou , KIM, Soojin , MULDER, Jason, Alan , PATEL, Nitinchandra , SENANAYAKE, Chris, H. , TAMPONE, Thomas, G. , WEI, Xudong
IPC分类号： C07D401/04 , C07D495/04 , C07C211/35 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is CI and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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8.发明公开SALZE EINES CGRP ANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG ALS ARZNEIMITTEL 审中-公开一个CGRP拮抗剂方法的盐生产和使用AS药物
公开(公告)号：EP2205587A2
公开(公告)日：2010-07-14
申请号：EP08804742.8
申请日：2008-09-25
IPC分类号： C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14
摘要： The invention relates to the novel salts AB of the base A with a physiologically acceptable acid B which is selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, fumaric acid and silcylic acid and the polymorphic compounds, the corresponding solvates and hydrates thereof.
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公开(公告)号：EP2625174B1
公开(公告)日：2015-01-21
申请号：EP11764572.1
申请日：2011-10-06
发明人： FRANK, Markus , HAEBERLE, Hans , HENRY, Manuel , PACHUR, Thorsten , SANTAGOSTINO, Marco , STERTZ, Uwe , TREBING, Thomas , WERTHMANN, Ulrike
IPC分类号： C07D401/14 , C07D211/58 , C07D213/81 , C07D401/04 , A61K31/454 , A61P31/00
CPC分类号： C07D401/14 , C07D211/58 , C07D213/81 , C07D401/04
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10.发明公开KRISTALLINE, ENANTIOMERENREINE SALZFORM EINES BETAMIMETIKUMS UND DESSEN VERWENDUNG ALS ARZNEIMITTEL 审中-公开水晶，β受体兴奋剂对映体纯盐的形式和其作为药物
公开(公告)号：EP2247581A2
公开(公告)日：2010-11-10
申请号：EP09713289.8
申请日：2009-02-17
IPC分类号： C07D265/18 , A61P11/00
CPC分类号： C07D265/18
摘要： The invention relates to a crystalline, enantiomerically pure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methane sulfonamide, preferably N-(5-{(R)-2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy- ethyl}-2-hydroxy-phenyl)-methane sulfonamide, and the effect thereof as a long-term betamimetic agent, alone or combined with at least one other active ingredient, in the treatment of respiratory diseases.
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