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1.发明公开TREATMENT OF DISEASES ASSOCIATED WITH ALTERED LEVEL OF AMYLOID BETA PEPTIDES 审中-公开治疗β-淀粉样肽级别切换的相关疾病
公开(公告)号：EP1750719A2
公开(公告)日：2007-02-14
申请号：EP05744035.6
申请日：2005-05-13
申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharmaceuticals, Inc. , Boehringer Ingelheim Pharma GmbH & Co. KG
发明人： BORNEMANN, Klaus , TRUMMLITZ, Guenter , LAZER, Edward, S. , MIAO, Clara, K. , BECK, Bernd , SAMS-DODD, Frank , KUGLER, Dagmar , KLINDER, Klaus , DORNER-CIOSSEK, Cornelia , KOSTKA, Marcus
IPC分类号： A61K31/541 , A61P21/00 , C07D279/02
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ß peptides (Aß) and/or with a changed ratio of levels of A isoforms and/or with the formation of plaques containing amyloid ß peptide (Aß) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas (Ia), (Ib) wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
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2.发明公开SUBSTITUTED ETHANE-1,2-DIAMINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE II 审中-公开取代的乙-1,2-二胺的阿尔茨海默病II的治疗
公开(公告)号：EP1913017A1
公开(公告)日：2008-04-23
申请号：EP06792629.5
申请日：2006-08-01
发明人： PETERS, Stefan , EICKMEIER, Christian , FUCHS, Klaus , STRANSKY, Werner , DORNER-CIOSSEK, Cornelia , KOSTKA, Marcus , HANDSCHUH, Sandra , NAR, Herbert , BORNEMANN, Klaus , KLINDER, Klaus , BAUER, Margit
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
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