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公开(公告)号：EP1915352A1
公开(公告)日：2008-04-30
申请号：EP06778201.1
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28 , C07D231/12 , C07D333/20 , C07D213/40 , C07D417/12 , C07D417/14 , A61K31/549 , A61K31/4439 , A61K31/4406 , A61K31/426 , A61K31/415 , A61K31/381 , A61P25/00
CPC分类号： C07D277/28 , C07D213/40 , C07D231/12 , C07D333/20 , C07D417/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claims, as well as the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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2.发明公开
公开(公告)号：EP1915353A2
公开(公告)日：2008-04-30
申请号：EP06792736.8
申请日：2006-08-08
发明人： HEINE, Niklas , FUCHS, Klaus , EICKMEIER, Christian , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28
CPC分类号： C07D417/12 , C07D213/40 , C07D277/28 , C07D333/20 , C07D409/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 - R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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公开(公告)号：EP1919861A2
公开(公告)日：2008-05-14
申请号：EP06792737.6
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , A61K31/427 , C07C311/08
CPC分类号： C07C311/08 , C07C307/10 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07D213/40 , C07D231/12 , C07D265/10 , C07D277/28 , C07D285/16 , C07D333/20 , C07D417/12
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 - R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1 -R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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4.发明公开INHIBITOREN DER BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG 审中-公开禁止使用BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG
公开(公告)号：EP1915339A1
公开(公告)日：2008-04-30
申请号：EP06792734.3
申请日：2006-08-08
发明人： EICKMEIER, Christian , FUCHS, Klaus , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , C07D295/22 , C07D265/10 , A61K31/54 , A61K31/535 , A61K31/426 , A61K31/427 , A61P25/28 , A61P35/00
CPC分类号： C07C307/10 , C07C2601/02 , C07D213/40 , C07D265/10 , C07D277/28 , C07D285/16 , C07D295/26 , C07D417/12
摘要： The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The invention also relates to the use thereof in the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其在治疗阿尔茨海默病（AD）和类似疾病中的用途。
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5.发明公开SUBSTITUTED ETHANE-1,2-DIAMINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE II 审中-公开取代的乙-1,2-二胺的阿尔茨海默病II的治疗
公开(公告)号：EP1913017A1
公开(公告)日：2008-04-23
申请号：EP06792629.5
申请日：2006-08-01
发明人： PETERS, Stefan , EICKMEIER, Christian , FUCHS, Klaus , STRANSKY, Werner , DORNER-CIOSSEK, Cornelia , KOSTKA, Marcus , HANDSCHUH, Sandra , NAR, Herbert , BORNEMANN, Klaus , KLINDER, Klaus , BAUER, Margit
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
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6.发明公开SUBSTITUTED 1,2-ETHYLENDIAMINES, MEDICAMENTS COMPRISING SAID COMPOUND; THEIR USE AND THEIR METHOD OF MANUFACTURE 审中-公开WITH THIS取代的1,2-乙二胺DRUG CONNECTION时，其用途和方法
公开(公告)号：EP1866034A1
公开(公告)日：2007-12-19
申请号：EP06723747.9
申请日：2006-03-27
发明人： EICKMEIER, Christian , FUCHS, Klaus , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HEINE, Niklas , HANDSCHUH, Sandra , KLINDER, Klaus , KOSTKA, Marcus
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
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公开(公告)号：EP1407043A2
公开(公告)日：2004-04-14
申请号：EP02745414.9
申请日：2002-06-27
CPC分类号： C12Q1/37 , G01N2500/04
摘要： According to the screening method of the invention substances capable of modulating η-secretase activity are identified by incubating a source and a substrate of η-secretase activity with a test substance and detecting a C-terminal fragment released from said substrate.
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公开(公告)号：EP1311471B1
公开(公告)日：2006-04-12
申请号：EP01971870.9
申请日：2001-08-04
发明人： FUCHS, Klaus , STRANSKY, Werner , GRAUERT, Matthias , CARTER, Adrian , GAIDA, Wolfram , WEISER, Thomas , ENSINGER, Helmut
IPC分类号： C07C217/48 , C07C211/35 , C07C211/27 , C07D295/092 , C07D295/125 , A61K31/137 , A61K31/14 , A61K31/40 , A61K31/4453 , A61P9/06 , A61P25/28
CPC分类号： C07D295/125 , C07C211/35 , C07C217/48 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/092
摘要： The invention relates to compounds of the general formula (1), wherein A, R?1, R2, R3, R4, R5 and R6¿ are defined as in the description and the claims. The invention further relates to a method for producing said compounds and to their use as medicaments. The compounds of formula (1) are used as blockers of the voltage-dependent sodium channel and can be used for diseases that are associated with a functional disorder caused by hyperexcitability.
摘要翻译： 本发明涉及通式（1）的化合物，其中A，R 1，R 2，R 3，R 4，R 5和R 6如 说明和权利要求。 本发明还涉及一种生产所述化合物的方法及其作为药物的用途。 式（1）的化合物用作电压依赖性钠通道的阻断剂，并且可用于与由兴奋性高的功能障碍相关的疾病。
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公开(公告)号：EP2822930B1
公开(公告)日：2016-01-20
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28 , A61K31/506 , C07C255/47 , C07C313/06 , C07D405/06 , C07C229/50 , C07C331/14
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
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10.发明授权1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS 有权1 - 杂环基-1,5-二氢 - 吡唑并[3,4-d]嘧啶-4- ON DERIVATIE及其作为调节剂的PDE9A
公开(公告)号：EP2300478B1
公开(公告)日：2016-03-23
申请号：EP09727328.8
申请日：2009-04-01
发明人： GIOVANNINI, Riccardo , DORNER-CIOSSEK, Cornelia , EICKMEIER, Christian , FIEGEN, Dennis , FOX, Thomas , FUCHS, Klaus , HEINE, Niklas , ROSENBROCK, Holger , SCHAENZLE, Gerhard
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04 , A61K31/519
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