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公开(公告)号：EP1915352A1
公开(公告)日：2008-04-30
申请号：EP06778201.1
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28 , C07D231/12 , C07D333/20 , C07D213/40 , C07D417/12 , C07D417/14 , A61K31/549 , A61K31/4439 , A61K31/4406 , A61K31/426 , A61K31/415 , A61K31/381 , A61P25/00
CPC分类号： C07D277/28 , C07D213/40 , C07D231/12 , C07D333/20 , C07D417/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claims, as well as the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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公开(公告)号：EP1919861A2
公开(公告)日：2008-05-14
申请号：EP06792737.6
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , A61K31/427 , C07C311/08
CPC分类号： C07C311/08 , C07C307/10 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07D213/40 , C07D231/12 , C07D265/10 , C07D277/28 , C07D285/16 , C07D333/20 , C07D417/12
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 - R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1 -R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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3.发明公开NEUE BRADYKININ-B1-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开新的缓激肽B1拮抗剂，方法生产及其作为药物
公开(公告)号：EP1812405A1
公开(公告)日：2007-08-01
申请号：EP05800514.1
申请日：2005-10-29
IPC分类号： C07D233/24 , C07D401/12 , C07D403/12 , C07D233/26 , C07D233/36 , C07D409/12 , C07D401/10 , C07D403/10 , C07D413/12 , C07D405/12 , C07D417/12 , A61K31/4164 , A61K31/4178 , A61P29/00 , A61P11/00
CPC分类号： C07D403/12 , C07D233/24 , C07D233/26 , C07D233/36 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to the bradykinin B1 antagonists of general formula (I), wherein A, Ar, G, Q, R1 and R4 are defined as in claim 1, to the enantiomers, diastereomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with organic or inorganic acids or bases. The inventive bradykinin B1 antagonists have valuable properties. The invention also relates to the production thereof, to the drugs comprising the pharmacologically effective compounds, to the production thereof and to their use.
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4.发明公开
公开(公告)号：EP1915353A2
公开(公告)日：2008-04-30
申请号：EP06792736.8
申请日：2006-08-08
发明人： HEINE, Niklas , FUCHS, Klaus , EICKMEIER, Christian , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28
CPC分类号： C07D417/12 , C07D213/40 , C07D277/28 , C07D333/20 , C07D409/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 - R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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5.发明公开SUBSTITUTED ETHANE-1,2-DIAMINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE II 审中-公开取代的乙-1,2-二胺的阿尔茨海默病II的治疗
公开(公告)号：EP1913017A1
公开(公告)日：2008-04-23
申请号：EP06792629.5
申请日：2006-08-01
发明人： PETERS, Stefan , EICKMEIER, Christian , FUCHS, Klaus , STRANSKY, Werner , DORNER-CIOSSEK, Cornelia , KOSTKA, Marcus , HANDSCHUH, Sandra , NAR, Herbert , BORNEMANN, Klaus , KLINDER, Klaus , BAUER, Margit
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
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6.发明公开SUBSTITUTED 1,2-ETHYLENDIAMINES, MEDICAMENTS COMPRISING SAID COMPOUND; THEIR USE AND THEIR METHOD OF MANUFACTURE 审中-公开WITH THIS取代的1,2-乙二胺DRUG CONNECTION时，其用途和方法
公开(公告)号：EP1866034A1
公开(公告)日：2007-12-19
申请号：EP06723747.9
申请日：2006-03-27
发明人： EICKMEIER, Christian , FUCHS, Klaus , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HEINE, Niklas , HANDSCHUH, Sandra , KLINDER, Klaus , KOSTKA, Marcus
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
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公开(公告)号：EP1802636B1
公开(公告)日：2013-03-27
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
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8.发明公开INHIBITOREN DER BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG 审中-公开禁止使用BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG
公开(公告)号：EP1915339A1
公开(公告)日：2008-04-30
申请号：EP06792734.3
申请日：2006-08-08
发明人： EICKMEIER, Christian , FUCHS, Klaus , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , C07D295/22 , C07D265/10 , A61K31/54 , A61K31/535 , A61K31/426 , A61K31/427 , A61P25/28 , A61P35/00
CPC分类号： C07C307/10 , C07C2601/02 , C07D213/40 , C07D265/10 , C07D277/28 , C07D285/16 , C07D295/26 , C07D417/12
摘要： The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The invention also relates to the use thereof in the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其在治疗阿尔茨海默病（AD）和类似疾病中的用途。
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公开(公告)号：EP1802636A1
公开(公告)日：2007-07-04
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
摘要： The invention relates to the novel compounds of formula (1), which, due to their pharmaceutical effect as PI3 kinase modulators, are suitable for use in the therapy and treatment of inflammatory or allergic diseases. Examples of these diseases are inflammatory and allergic respiratory diseases, inflammatory diseases of the gastro-intestinal system and of the locomotor apparatus, inflammatory and allergic skin diseases, inflammatory ophthalmic diseases, diseases of the nasal mucosa, inflammatory or allergic autoimmune reactive conditions, or renal inflammations.
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公开(公告)号：EP4192853A1
公开(公告)日：2023-06-14
申请号：EP21763019.3
申请日：2021-08-05
发明人： HAEBEL, Peter , BRENNAUER, Albert , PETERS, Stefan , MADSEN,, Charlotte, Stahl , PEDERSEN, Søren, Ljungberg
IPC分类号： C07K14/575 , A61K38/22
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