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公开(公告)号：EP1919861A2
公开(公告)日：2008-05-14
申请号：EP06792737.6
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , A61K31/427 , C07C311/08
CPC分类号： C07C311/08 , C07C307/10 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07D213/40 , C07D231/12 , C07D265/10 , C07D277/28 , C07D285/16 , C07D333/20 , C07D417/12
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 - R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1 -R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其用于治疗阿尔茨海默病（AD）和类似疾病的用途。
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2.发明公开
公开(公告)号：EP1748996A1
公开(公告)日：2007-02-07
申请号：EP05741893.1
申请日：2005-05-07
发明人： PFAU, Roland , PRIEPKE, Henning , GERLACH, Kai , WIENEN, Wolfgang , SCHULER-METZ, Annette , DAHMANN, Georg , NAR, Herbert , HANDSCHUH, Sandra
IPC分类号： C07D333/38 , C07D409/12 , C07D417/12 , C07D409/14 , A61K31/551 , A61P7/02
CPC分类号： C07D333/38 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The invention relates to novel substituted thiophen-2-carboxylic acid amides of general formula (I), wherein A and R1 to R8 are defined as specified in the claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, in particular the salts thereof which are physiologically compatible with inorganic or organic acids or bases and exhibit interesting properties.
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3.发明授权SUBSTITUIERTE GLYCINAMIDE MIT ANTITHROMBOTISCHER UND FAKTOR XA-INHIBIERENDER WIRKUNG 有权具有抗血栓和Xa因子的抑制效果取代甘氨酸酰胺
公开(公告)号：EP1899330B1
公开(公告)日：2010-11-24
申请号：EP06763910.4
申请日：2006-06-28
发明人： WIENEN, Wolfgang , PFAU, Roland , GERLACH, Kai , DAHMANN, Georg , PRIEPKE, Henning , NAR, Herbert , HANDSCHUH, Sandra , SCHULER-METZ, Annette
IPC分类号： C07D409/14 , C07D409/12 , C07D487/04 , C07D413/04 , C07D417/14 , C07D471/04 , A61K31/55 , A61P29/00 , A61P35/00 , A61P9/00
CPC分类号： C07D487/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08
摘要： The invention relates to novel substituted glycinamides of general formula (I), wherein D, M, R3, R4, and R5 are defined as indicated in the description, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, which are provided with valuable characteristics.
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公开(公告)号：EP1915352A1
公开(公告)日：2008-04-30
申请号：EP06778201.1
申请日：2006-08-08
发明人： FUCHS, Klaus , EICKMEIER, Christian , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28 , C07D231/12 , C07D333/20 , C07D213/40 , C07D417/12 , C07D417/14 , A61K31/549 , A61K31/4439 , A61K31/4406 , A61K31/426 , A61K31/415 , A61K31/381 , A61P25/00
CPC分类号： C07D277/28 , C07D213/40 , C07D231/12 , C07D333/20 , C07D417/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claims, as well as the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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5.发明公开SUBSTITUIERTE GLYCINAMIDE MIT ANTITHROMBOTISCHER UND FAKTOR XA-INHIBIERENDER WIRKUNG 有权具有抗血栓和Xa因子的抑制效果取代甘氨酸酰胺
公开(公告)号：EP1899330A1
公开(公告)日：2008-03-19
申请号：EP06763910.4
申请日：2006-06-28
发明人： WIENEN, Wolfgang , PFAU, Roland , GERLACH, Kai , DAHMANN, Georg , PRIEPKE, Henning , NAR, Herbert , HANDSCHUH, Sandra , SCHULER-METZ, Annette
IPC分类号： C07D409/14 , C07D409/12 , C07D487/04 , C07D413/04 , C07D417/14 , C07D471/04 , A61K31/55 , A61P29/00 , A61P35/00 , A61P9/00
CPC分类号： C07D487/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08
摘要： The invention relates to novel substituted glycinamides of general formula (I), wherein D, M, R3, R4, and R5 are defined as indicated in the description, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, which are provided with valuable characteristics.
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6.发明公开
公开(公告)号：EP1915353A2
公开(公告)日：2008-04-30
申请号：EP06792736.8
申请日：2006-08-08
发明人： HEINE, Niklas , FUCHS, Klaus , EICKMEIER, Christian , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07D277/28
CPC分类号： C07D417/12 , C07D213/40 , C07D277/28 , C07D333/20 , C07D409/12 , C07D417/14
摘要： The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 - R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
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7.发明公开BENZIMIDAZOLE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开的苯并咪唑，对于其方法及其作为药物
公开(公告)号：EP1756068A1
公开(公告)日：2007-02-28
申请号：EP05751720.3
申请日：2005-06-03
发明人： PRIEPKE, Henning , GERLACH, Kai , PFAU, Roland , WIENEN, Wolfgang , SCHULER-METZ, Annette , HANDSCHUH, Sandra , NAR, Herbert
IPC分类号： C07D235/16 , A61K31/4184 , A61P7/02
CPC分类号： C07D417/12 , C07D235/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D409/12 , C07D413/12 , C07D413/14
摘要： The invention relates to the novel substituted benzimidazoles of general formula (I), wherein R1 to R6 are defined as in claim 1, to the tautomers, enantiomers, diastereomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases. The novel substances have valuable properties.
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8.发明公开SUBSTITUIERTE THIOPHEN-2-CARBONSÄUREAMIDE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开取代的噻吩-2-羧酸酰胺，其制备及其作为药物
公开(公告)号：EP1748997A1
公开(公告)日：2007-02-07
申请号：EP05745599.0
申请日：2005-05-07
发明人： PFAU, Roland , PRIEPKE, Henning , GERLACH, Kai , WIENEN, Wolfgang , SCHULER-METZ, Annette , NAR, Herbert , HANDSCHUH, Sandra
IPC分类号： C07D333/38 , C07D413/12 , C07D409/12 , A61K31/551 , A61P7/02
CPC分类号： C07D333/38
摘要： The present invention concerns new substituted thiophene-2-carboxylic acid amides of general formula (I), in which A and R1 to R8c are as defined in claim 1, tautomers, enantiomers, diastereomers, mixtures and salts thereof, in particular the physiologically compatible salts thereof with inorganic or organic acids or bases, which have valuable properties.
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9.发明公开INHIBITOREN DER BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG 审中-公开禁止使用BETA-SEKRETASE ZUR BEHANDLUNG DER ALZHEIMER- ERKRANKUNG
公开(公告)号：EP1915339A1
公开(公告)日：2008-04-30
申请号：EP06792734.3
申请日：2006-08-08
发明人： EICKMEIER, Christian , FUCHS, Klaus , HEINE, Niklas , PETERS, Stefan , DORNER-CIOSSEK, Cornelia , HANDSCHUH, Sandra , NAR, Herbert , KLINDER, Klaus
IPC分类号： C07C307/10 , C07D417/12 , C07D285/16 , C07D277/28 , C07D213/40 , C07D295/22 , C07D265/10 , A61K31/54 , A61K31/535 , A61K31/426 , A61K31/427 , A61P25/28 , A61P35/00
CPC分类号： C07C307/10 , C07C2601/02 , C07D213/40 , C07D265/10 , C07D277/28 , C07D285/16 , C07D295/26 , C07D417/12
摘要： The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The invention also relates to the use thereof in the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 13，A，B，L和i如说明书和权利要求中所定义。 本发明还涉及其在治疗阿尔茨海默病（AD）和类似疾病中的用途。
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10.发明公开NEUE SUBSTITUIERTE THIOPHENCARBONSÄUREAMIDE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开NEUE SUBSTITUIERTETHIOPHENCARBONSÄUREAMIDE，DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
公开(公告)号：EP1747217A1
公开(公告)日：2007-01-31
申请号：EP05747401.7
申请日：2005-05-07
发明人： PFAU, Roland , PRIEPKE, Henning , GERLACH, Kai , WIENEN, Wolfgang , SCHULER-METZ, Annette , NAR, Herbert , HANDSCHUH, Sandra
IPC分类号： C07D413/12 , C07D409/12 , C07D417/12 , C07D419/12 , C07D413/14 , A61K31/554 , A61P7/02
CPC分类号： C07D413/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D419/12
摘要： The invention relates to novel substituted thiophene-2-carboxamides of general formula (I), in which A, and R1 to R8c are defined as cited in claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts, in particular the physiologically compatible salts of said compounds containing inorganic or organic acids or bases, which exhibit valuable properties.
摘要翻译： 本发明涉及通式（I）的新的取代的噻吩-2-甲酰胺，其中A 1和R 1 -R 8c如权利要求1中所定义。本发明还涉及互变异构体，对映异构体，非对映异构体，混合物和盐， 特别是含有无机或有机酸或碱的所述化合物的生理上相容的盐，其显示有价值的性质。
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