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公开(公告)号：EP2822930B1
公开(公告)日：2016-01-20
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28 , A61K31/506 , C07C255/47 , C07C313/06 , C07D405/06 , C07C229/50 , C07C331/14
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
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公开(公告)号：EP2822930A1
公开(公告)日：2015-01-14
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍及其作为β-分泌酶（BACE1）活性抑制剂的用途，含有该化合物的药物组合物，以及使用该化合物作为治疗剂治疗神经变性疾病，以认知衰退为特征的疾病的方法 ，认知障碍，痴呆和特征在于产生β-淀粉样蛋白聚集体的疾病。
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3.发明授权STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 有权某些TRIFLUORMETHYLSUBSTITUIERTER醇的立体选择性合成
公开(公告)号：EP1934218B1
公开(公告)日：2009-11-18
申请号：EP06803728.2
申请日：2006-09-18
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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4.发明公开STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 有权某些TRIFLUORMETHYLSUBSTITUIERTER醇的立体选择性合成
公开(公告)号：EP1934218A1
公开(公告)日：2008-06-25
申请号：EP06803728.2
申请日：2006-09-18
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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