公开(公告)号：EP1471899A1

公开(公告)日：2004-11-03

申请号：EP03731681.7

申请日：2003-01-21

申请人： Boehringer Ingelheim Pharma GmbH & Co.KG

发明人： GAIDA, Wolfram ,  KLINDER, Klaus ,  WEISER, Thomas

IPC分类号： A61K31/136 ,  A61P9/06 ,  A61P25/08 ,  A61P25/06 ,  A61P25/02

CPC分类号： A61K9/0095 ,  A61K9/0019 ,  A61K9/02 ,  A61K9/2059 ,  A61K9/2826 ,  A61K9/4866 ,  A61K31/136 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K2300/00

摘要： The invention relates to the use of ambroxol and the pharmaceutically acceptable salts thereof for producing a drug for the treatment of diseases that are caused by a strong activation of voltage-gated sodium channels, especially for the treatment of chronic pains, cerebral excitotoxicity-related disorders and cardiac arrhythmias.

公开(公告)号：EP1235809B1

公开(公告)日：2003-11-12

申请号：EP00993781.4

申请日：2000-11-21

申请人： Boehringer Ingelheim Pharma GmbH & Co.KG

发明人： GRAUERT, Matthias ,  CARTER, Adrian ,  WEISER, Thomas ,  ENSINGER, Helmut ,  GAIDA, Wolfram ,  MIERAU, Joachim

IPC分类号： C07D221/26 ,  C07D221/22 ,  C07D407/06 ,  A61K31/445

CPC分类号： C07D405/06 ,  C07D221/26

摘要： The invention relates to substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of the general formula (1), wherein the groups R?1, R2, R3, R3', R4, R5, R6¿, X and A are defined as per the description and claims, to a method for their production and to the use thereof as medicaments.

公开(公告)号：EP1471899B1

公开(公告)日：2007-10-24

申请号：EP03731681.7

申请日：2003-01-21

申请人： Boehringer Ingelheim Pharma GmbH & Co.KG

发明人： GAIDA, Wolfram ,  KLINDER, Klaus ,  WEISER, Thomas

IPC分类号： A61K31/136 ,  A61P25/06 ,  A61P25/02

CPC分类号： A61K9/0095 ,  A61K9/0019 ,  A61K9/02 ,  A61K9/2059 ,  A61K9/2826 ,  A61K9/4866 ,  A61K31/136 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K2300/00

摘要： The invention relates to the use of ambroxol and the pharmaceutically acceptable salts thereof for producing a drug for the treatment of diseases that are caused by a strong activation of voltage-gated sodium channels, especially for the treatment of chronic pains, cerebral excitotoxicity-related disorders and cardiac arrhythmias.

公开(公告)号：EP1725225A1

公开(公告)日：2006-11-29

申请号：EP04741038.6

申请日：2004-07-15

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co.KG

发明人： WEISER, Thomas ,  KLINDER, Klaus ,  GAIDA, Wolfram

IPC分类号： A61K31/137 ,  A61K45/06

CPC分类号： A61K45/06 ,  A61K31/137 ,  A61K2300/00

摘要： The invention concerns the use of ambroxol and its pharmaceutically acceptable salts for producing a medicine for treating an acute pain.