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公开(公告)号：EP1648435A1
公开(公告)日：2006-04-26
申请号：EP04741039.4
申请日：2004-07-15
发明人： WEISER, Thomas , PILGRAMM, Manfred
IPC分类号： A61K31/136 , A61P27/16
CPC分类号： A61K45/06 , A61K31/136 , A61K31/137 , A61K2300/00
摘要： The invention concerns the use of ambroxol and its pharmaceutically acceptable salts for producing a medicine for treating tinnitus and other otologic disorders.
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2.发明授权
公开(公告)号：EP0934288B1
公开(公告)日：2006-01-04
申请号：EP97911227.3
申请日：1997-10-15
发明人： BRENNER, Michael , MAIER, Roland , WIENRICH, Marion , WEISER, Thomas , PALLUK, Rainer , BECHTEL, Wolf-Dietrich , SAGRADA, Angelo , ENSINGER, Helmut , PSCHORN, Uwe , CESANA, Raffaele
IPC分类号： C07D271/06 , C07D413/04 , C07D413/12 , C07D451/06 , C07D471/08 , A61K31/41 , C07D221/00 , C07D209/00
CPC分类号： C07D271/06 , C07D413/04
摘要： The invention concerns oxadiazole derivatives of general formula (I) in which X, Y, Z and R1 have the definitions given in the description and the claims. The invention further concerns processes for preparing these substances and their use as medicaments.
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公开(公告)号：EP1725225A1
公开(公告)日：2006-11-29
申请号：EP04741038.6
申请日：2004-07-15
发明人： WEISER, Thomas , KLINDER, Klaus , GAIDA, Wolfram
IPC分类号： A61K31/137 , A61K45/06
CPC分类号： A61K45/06 , A61K31/137 , A61K2300/00
摘要： The invention concerns the use of ambroxol and its pharmaceutically acceptable salts for producing a medicine for treating an acute pain.
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4.发明授权NEUE POSITIVE ALLOSTERISCHE AMPA-REZEPTOR MODULATOREN (PAARM), VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的积极变构AMPA受体调节剂（PAARM）用于AS药物PRODUCING及其用途
公开(公告)号：EP1265904B1
公开(公告)日：2004-09-22
申请号：EP01911553.4
申请日：2001-01-30
IPC分类号： C07D513/06 , A61K31/54 , A61P25/00
CPC分类号： C07D513/06
摘要： The invention relates to novel, positive allosteric AMPA receptor modulators of general formula (I), wherein R?1, R2, R3, R4, R5 and R6¿ have the meanings cited in the description and claims. The invention also relates to a method for the production and use thereof as medicaments.
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5.发明公开NEUE ARZNEIMITTELKOMBINATIONEN AUF DER BASIS VON NATRIUMKANALBLOCKERN UND MAGNESIUMSALZEN 审中-公开NEW药物的组合基于钠通道阻断剂和镁盐
公开(公告)号：EP1521579A1
公开(公告)日：2005-04-13
申请号：EP03762507.6
申请日：2003-06-25
发明人： DUETTMANN, Hermann , WEISER, Thomas
CPC分类号： A61K45/06 , A61K31/439 , A61K31/46 , A61K33/06 , A61K33/10 , A61K2300/00
摘要： The invention relates to novel medicament combinations based on sodium channel blockers (1) and magnesium salts (2). The invention also relates to a method for the production thereof and the use thereof in the production of medicaments for the treatment of ischaemic states.
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6.发明公开
公开(公告)号：EP1471899A1
公开(公告)日：2004-11-03
申请号：EP03731681.7
申请日：2003-01-21
发明人： GAIDA, Wolfram , KLINDER, Klaus , WEISER, Thomas
IPC分类号： A61K31/136 , A61P9/06 , A61P25/08 , A61P25/06 , A61P25/02
CPC分类号： A61K9/0095 , A61K9/0019 , A61K9/02 , A61K9/2059 , A61K9/2826 , A61K9/4866 , A61K31/136 , A61K45/06 , A61K47/12 , A61K47/26 , A61K2300/00
摘要： The invention relates to the use of ambroxol and the pharmaceutically acceptable salts thereof for producing a drug for the treatment of diseases that are caused by a strong activation of voltage-gated sodium channels, especially for the treatment of chronic pains, cerebral excitotoxicity-related disorders and cardiac arrhythmias.
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7.发明授权SUBSTITUIERTE 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCIN-10-OLE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权取代的1,2,3,4,5,6-六氢-2,6-亚甲基-3- benzazocine-10 OLE，制造方法相同，并且它们作为药物
公开(公告)号：EP1015433B1
公开(公告)日：2004-05-26
申请号：EP98950009.5
申请日：1998-09-09
发明人： GRAUERT, Matthias , CARTER, Adrian , BECHTEL, Wolf-Dietrich , WEISER, Thomas , PALLUK, Rainer , PSCHORN, Uwe
IPC分类号： C07D221/26 , A61K31/435 , A61K31/485
CPC分类号： C07D221/26
摘要： The invention relates to novel substituted 1,2,3,4,5,6-hexahydro-2.6-methano-3-benzazocine-10-oles of general formula (I), and to a method for the production and the use thereof as medicaments.
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8.发明授权SUBSTITUIERTE 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCINE UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权取代1,2,3,4,5,6六氢-2,6-亚甲基-3- benzazocines及其作为药物
公开(公告)号：EP1235809B1
公开(公告)日：2003-11-12
申请号：EP00993781.4
申请日：2000-11-21
发明人： GRAUERT, Matthias , CARTER, Adrian , WEISER, Thomas , ENSINGER, Helmut , GAIDA, Wolfram , MIERAU, Joachim
IPC分类号： C07D221/26 , C07D221/22 , C07D407/06 , A61K31/445
CPC分类号： C07D405/06 , C07D221/26
摘要： The invention relates to substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of the general formula (1), wherein the groups R?1, R2, R3, R3', R4, R5, R6¿, X and A are defined as per the description and claims, to a method for their production and to the use thereof as medicaments.
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9.发明授权
公开(公告)号：EP1077950B1
公开(公告)日：2004-09-22
申请号：EP99920662.6
申请日：1999-04-14
发明人： BRENNER, Michael , PALLUK, Rainer , WIENRICH, Marion , WEISER, Thomas , CEREDA, Enzo , BIGNOTTI, Maura , PELLEGRINI, Carlo Maria , SCHIAVI, Giovanni, Battista , CESANA, Raffaele
IPC分类号： C07D239/26 , C07D239/36 , C07D251/22 , C07D253/06 , A61K31/505 , A61K31/53
CPC分类号： C07D239/26 , C07D239/36 , C07D251/16 , C07D253/065
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10.发明授权
公开(公告)号：EP1154983B1
公开(公告)日：2004-04-28
申请号：EP00907556.5
申请日：2000-02-12
发明人： STRANSKY, Werner , GRAUERT, Matthias , CARTER, Adrian , WEISER, Thomas , BECHTEL, Wolf-Dietrich , ENSINGER, Helmut , LOTZ, Ralf, Richard, Hermann , PALLUK, Rainer , PSCHORN, Uwe
IPC分类号： C07C217/48 , C07D295/08 , C07D307/52 , C07D309/14 , C07D233/48 , A61K31/138 , A61K31/4453 , A61P9/06 , A61P25/28
CPC分类号： C07D295/088 , C07C217/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/66 , C07D233/48 , C07D307/52 , C07D309/14
摘要： The invention relates to novel substituted 3-phenoxy or 3-phenylalkyloxy-2-phenyl-propylamines of general formula (1), to methods for producing them and to their use as medicaments.
摘要翻译： 本发明涉及通式（1）的新型取代的3-苯氧基或3-苯基烷氧基-2-苯基 - 丙胺，其制备方法和用作药物。
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